(Q40501417)

21 September 2017

Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein (English)

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21 September 2017

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Louise C Serpell

4

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author name string

Woong Choi

1

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21 September 2017

Shahin Zibaee

2

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21 September 2017

Ross Jakes

3

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21 September 2017

Bazbek Davletov

5

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21 September 2017

R Anthony Crowther

6

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21 September 2017

Michel Goedert

7

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21 September 2017

language of work or name

English

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publication date

1 October 2004

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21 September 2017

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21 September 2017

576

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21 September 2017

363-368

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21 September 2017

3

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Alpha-synuclein and neurodegenerative diseases

21 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Staging of brain pathology related to sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Alpha-synuclein in Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Characterisation of isolated alpha-synuclein filaments from substantia nigra of Parkinson's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Identification of two distinct synucleins from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Conformational properties of alpha-synuclein in its free and lipid-associated states

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

A broken alpha -helix in folded alpha -Synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Synthetic filaments assembled from C-terminally truncated alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Structural organization of alpha-synuclein fibrils studied by site-directed spin labeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Yeast cells provide insight into alpha-synuclein biology and pathobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Lipid rafts mediate the synaptic localization of alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Membrane binding and self-association of alpha-synucleins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Small-volume extrusion apparatus for preparation of large, unilamellar vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavin T1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Asymmetry of lipid organization in cholinergic synaptic vesicle membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Alpha-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

alpha-Synuclein A53T substitution associated with Parkinson disease also marks the divergence of Old World and New World primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Straight and paired helical filaments in Alzheimer disease have a common structural unit

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Abnormal tau-containing filaments in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

alpha-Synuclein-synaptosomal membrane interactions: implications for fibrillogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Lipid binding inhibits alpha-synuclein fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

The association of alpha-synuclein with membranes affects bilayer structure, stability, and fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

Production of large unilamellar vesicles by a rapid extrusion procedure: characterization of size distribution, trapped volume and ability to maintain a membrane potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.09.038

10.1016/J.FEBSLET.2004.09.038

21 January 2018

Identifiers

DOI

1 reference

21 September 2017

1 reference