(Q40525143)

21 September 2017

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title

The genetic regulation of apoptosis (English)

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21 September 2017

Wyllie AH

1

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21 September 2017

1 February 1995

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Current Opinion in Genetics & Development

21 September 2017

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21 September 2017

5

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21 September 2017

97-104

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21 September 2017

1

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Bcl-2 and the regulation of programmed cell death

21 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Cell death in health and disease: the biology and regulation of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Programmed cell death and the control of cell survival: lessons from the nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

A novel domain within the 55 kd TNF receptor signals cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Programmed cell death induced by ceramide

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Purification and characterization of the Fas-ligand that induces apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule

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https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

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https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Induction of apoptosis in fibroblasts by c-myc protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Requirement for a functional Rb-1 gene in murine development

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https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Mediation of c-Myc-induced apoptosis by p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Thymocyte apoptosis induced by p53-dependent and independent pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

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https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Apoptosis in erythroid progenitors deprived of erythropoietin occurs during the G1 and S phases of the cell cycle without growth arrest or stabilization of wild-type p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Neither macromolecular synthesis nor myc is required for cell death via the mechanism that can be controlled by Bcl-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Premature p34cdc2 activation required for apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Cdc2 activation is not required for thymocyte apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Susceptibility to apoptosis is differentially regulated by c-myc and mutated Ha-ras oncogenes and is associated with endonuclease availability

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Genetic control of programmed cell death in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Checkpoints of dueling dimers foil death wishes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Bcl-2 blocks p53-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Bcl-2 associates with the ras-related protein R-ras p23

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Cooperative tumorigenic effects of germline mutations in Rb and p53

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Latent membrane protein of Epstein-Barr virus induces cellular phenotypes independently of expression of Bcl-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

Prevention of vertebrate neuronal death by the crmA gene

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2895%2990060-8

7 January 2021

10.1016/S0959-437X(95)90060-8

Identifiers

DOI

1 reference

21 September 2017

1 reference

PubMed ID

7749333