(Q40528537)

21 September 2017

title

Spontaneous mutation in Big Blue mice from fetus to old age: tissue-specific time courses of mutation frequency but similar mutation types (English)

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21 September 2017

6

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21 September 2017

Kathleen A Hill

1

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21 September 2017

Victoria L Buettner

2

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21 September 2017

Asanga Halangoda

3

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21 September 2017

Makoto Kunishige

4

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21 September 2017

Stephen R Moore

5

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21 September 2017

William A Scaringe

7

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21 September 2017

Steve S Sommer

8

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21 September 2017

publication date

1 January 2004

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Environmental and Molecular Mutagenesis

21 September 2017

published in

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21 September 2017

volume

43

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21 September 2017

issue

2

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21 September 2017

page(s)

110-120

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Chromosomal damage and ageing: effect on micronuclei frequency in peripheral blood lymphocytes

21 September 2017

cites work

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Tandem-base mutations occur in mouse liver and adipose tissue preferentially as G:C to T:A transversions and accumulate with age.

21 January 2018

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Rapid accumulation of genome rearrangements in liver but not in brain of old mice

21 January 2018

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Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine

21 January 2018

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Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

21 January 2018

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Cell number and cell density in the cerebellar cortex of man and some other mammals

21 January 2018

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The effect of aging on sister chromatid exchange

21 January 2018

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Granule neurons and their significance in preparations of isolated brain cell nuclei

21 January 2018

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Mutation frequency declines during spermatogenesis in young mice but increases in old mice

21 January 2018

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Neural populations in the human cerebellum: estimations from isolated cell nuclei

21 January 2018

1 reference

Genetic stability: the key to longevity?

21 January 2018

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In vivo transgenic mutation assays

21 January 2018

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Peroxynitrite formation from macrophage-derived nitric oxide

21 January 2018

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Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans

21 January 2018

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Comparison of neuronal and glial numerical density in primary and secondary visual cortex of man

21 January 2018

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Somatic mutations are frequent and increase with age in human kidney epithelial cells

21 January 2018

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A longitudinal study of human age-related chromosomal analysis in skin fibroblasts

21 January 2018

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Accelerated accumulation of somatic mutations in the senescence-accelerated mouse

21 January 2018

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Spontaneous mutant frequency of lacZ gene in spleen of transgenic mouse increases with age

21 January 2018

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Factors affecting somatic mutation frequencies in vivo

21 January 2018

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Endogenous DNA damage as related to cancer and aging

21 January 2018

1 reference

7 January 2021

The causes and prevention of cancer

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7 January 2021

Spontaneous mutation frequencies and spectra in p53 (+/+) and p53 (-/-) mice: a test of the 'guardian of the genome' hypothesis in the Big Blue transgenic mouse mutation detection system

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7 January 2021

Transgenic lambda/lacI mutagenicity assay: statistical determination of sample size

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7 January 2021

Age-associated structural alterations in senescent mouse brain DNA.

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7 January 2021

Effects of extended chronic exposures on endogenous and transgenic loci: implications for low-dose extrapolations

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7 January 2021

Frequency of spontaneous and induced micronuclei in the peripheral blood of aging mice

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7 January 2021

Spontaneous mutation in lacI transgenic mice: a comparison of tissues

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7 January 2021

The aging process and cancerogenesis

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7 January 2021

Sequence of the lacI gene

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7 January 2021

Chromosomal damage rate, aging, and diet

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7 January 2021

Determination of hprt mutant frequencies in T-lymphocytes from a healthy pediatric population: statistical comparison between newborn, children and adult mutant frequencies, cloning efficiency and age.

1 reference

7 January 2021

Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo

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7 January 2021

In vivo human somatic mutation: frequency and spectrum with age

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7 January 2021

Bi-directional dideoxy fingerprinting (Bi-ddF): rapid and efficient screening for mutations in the Big Blue transgenic mouse mutation detection system.

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7 January 2021

Organization of heterologous DNA inserts on the mouse meiotic chromosome core

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7 January 2021

Spontaneous mutations in the Big Blue transgenic system are primarily mouse derived

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7 January 2021

The Big Blue(R) transgenic mouse mutation detection assay: the mutation pattern of sectored mutant plaques

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7 January 2021

Spontaneous tandem-base mutations (TBM) show dramatic tissue, age, pattern and spectrum specificity

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7 January 2021

Possible factors leading to a misjudgement of mutant frequencies in HPRT assay

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7 January 2021

Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/lacl shuttle vector

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7 January 2021

Comparative analysis of DNA mutations in lacI transgenic mice with age.

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7 January 2021

Somatic mutation and aging

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7 January 2021

Towards validation of the Big Blue transgenic mouse mutagenesis assay: the mutational spectrum of ex vivo pinpoint mutant plaques

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7 January 2021

Recent advances in the protocols of transgenic mouse mutation assays.

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7 January 2021

Age-associated increase of spontaneous mutant frequency and molecular nature of mutation in newborn and old lacZ-transgenic mouse.

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7 January 2021

Spontaneous mutation during fetal development and post-natal growth

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7 January 2021

On the origin of spontaneous somatic mutations and sectored plaques detected in transgenic mice

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7 January 2021

Study design and sample sizes for a lacI transgenic mouse mutation assay

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7 January 2021

Characterization of mutations induced by ethylnitrosourea in seminiferous tubule germ cells of transgenic B6C3F1 mice

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7 January 2021

An analysis of in vivo hprt mutant frequency in circulating T-lymphocytes in the normal human population: a comparison of four datasets

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7 January 2021

ON THE NATURE OF THE AGING PROCESS

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7 January 2021

Comparison of somatic mutation in a transgenic versus host locus

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7 January 2021

Somatic mutations and aging: a re-evaluation

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7 January 2021

Transgenic mice and age-related mutations

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7 January 2021

Identifiers

DOI

10.1002/EM.20004

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21 September 2017

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