(Q33844435)

29 July 2017

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title

Somatic mutations and aging: a re-evaluation (English)

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29 July 2017

Vijg J

1

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29 July 2017

language of work or name

English

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publication date

1 January 2000

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29 July 2017

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29 July 2017

volume

447

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29 July 2017

issue

1

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29 July 2017

page(s)

117-135

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The biologic effects of pile radiations.

29 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

The aging process and cancerogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

ON THE NATURE OF THE AGING PROCESS

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Correlation Between Deoxyribonucleic Acid Excision-Repair and Life-Span in a Number of Mammalian Species

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Shortening of the life span of mice by irradiation with x-rays and treatment with radiomimetic chemicals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

The modification by x-irradiation of the life span of haploids and diploids of the wasp, Habrobracon sp.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Is ageing the result of dominant and co-dominant mutations?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

What good is it to get old?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Genetic analysis of ageing: role of oxidative damage and environmental stresses.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Pleiotropy, Natural Selection, and the Evolution of Senescence

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Oxidants, antioxidants, and the degenerative diseases of aging

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Oxidative DNA damage, antioxidants, and cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Mutation and senescence: where genetics and demography meet.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

7 January 2021

DNA, mutations and aging

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

THE RELATION OF RECOMBINATION TO MUTATIONAL ADVANCE

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Estimate of the genomic mutation rate deleterious to overall fitness in E. coli.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Test of synergistic interactions among deleterious mutations in bacteria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Muller's ratchet decreases fitness of a DNA-based microbe

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Instability and decay of the primary structure of DNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Role of free radicals in aging and disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Inducible repair of thymine glycol detected by an ultrasensitive assay for DNA damage.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Chromosome Aberrations in Liver Cells in Relation to the Somatic Mutation Theory of Aging

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Frequency of spontaneous chromosome aberrations in mice: effects of age.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

In vivo mutations in human blood cells: biomarkers for molecular epidemiology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Effect of dietary restriction on in vivo somatic mutation in mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

In vivo human somatic mutation: frequency and spectrum with age

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Monitoringhprt mutant frequency over time in T-lymphocytes of people accidentally exposed to high doses of ionizing radiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Caloric restriction and aging

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Accelerated accumulation of somatic mutations in the senescence-accelerated mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Somatic mutations are frequent and increase with age in human kidney epithelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Use of transgenic mouse models for studying somatic mutations in aging

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Comparative analysis of DNA mutations in lacI transgenic mice with age.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Rapid accumulation of genome rearrangements in liver but not in brain of old mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Age-associated increase of spontaneous mutant frequency and molecular nature of mutation in newborn and old lacZ-transgenic mouse.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Parsing age, mutations and time

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

High somatic mutation frequencies in a LacZ transgene integrated on the mouse X-chromosome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Minisatellites and human disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Full-length human L1 insertions retain the capacity for high frequency retrotransposition in cultured cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Repeat unit sequence variation in minisatellites: a novel source of DNA polymorphism for studying variation and mutation by single molecule analysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Mouse minisatellite mutations induced by ionizing radiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Extension of life-span by introduction of telomerase into normal human cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Telomere length and replicative aging in human vascular tissues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Comparison of chromosome telomere integrity in multiple tissues from subjects at different ages

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Genotypic selection of mitochondrial and oncogenic mutations in human tissue suggests mechanisms of age-related pathophysiology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Oxidative DNA damage processing in nuclear and mitochondrial DNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Double strand break rejoining by mammalian mitochondrial extracts.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

An age-associated correlation between cellular bioenergy decline and mtDNA rearrangements in human skeletal muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

New prospects for human stem-cell therapy in the nervous system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Viable offspring derived from fetal and adult mammalian cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Apoptosis and its role in human disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

A unifying hypothesis to explain the retardation of aging and tumorigenesis by caloric restriction.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Genetic instabilities in human cancers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Transgenic assays for mutations and cancer: current status and future perspectives

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

A genetic model for colorectal tumorigenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Accumulation of genetic alterations and their significance in each primary human cancer and cell line

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

The mutation rate and cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Microsatellite instability: the mutator that mutates the other mutator

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Mismatch Repair Deficiency in Phenotypically Normal Human Cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Tumors of DNA mismatch repair-deficient hosts exhibit dramatic increases in genomic instability

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Estimation of mutation frequencies in normal mammalian cells and the development of cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

The serial cultivation of human diploid cell strains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Replicative senescence: an old lives' tale?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Unusual DNA structures, chromatin and transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

The estimation of in vivo mutation rate and frequency from samples of human lymphocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Positional cloning of the Werner's syndrome gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

The DNA helicase activity of BLM is necessary for the correction of the genomic instability of bloom syndrome cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Mutator phenotype of Werner syndrome is characterized by extensive deletions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenarians

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Cockayne syndrome: defective repair of transcription?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Somatic cell mutation frequency at the HPRT, T-cell antigen receptor and glycophorin A loci in Cockayne syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Reduced RNA polymerase II transcription in extracts of cockayne syndrome and xeroderma pigmentosum/Cockayne syndrome cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Cancer from the outside, aging from the inside: mouse models to study the consequences of defective nucleotide excision repair

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Accelerated accumulation of somatic mutations in mice deficient in the nucleotide excision repair gene XPA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Randomness, redundancy and repair: roles and relevance to biological aging.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Essential role of mouse telomerase in highly proliferative organs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Genetic and Environmental Modulations of Chromosomal Stability: Their Roles in Aging and Oncogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Variation in DNA repair is a factor in cancer susceptibility: a paradigm for the promises and perils of individual and population risk estimation?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Siblings of centenarians live longer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Distinctive gene expression patterns in human mammary epithelial cells and breast cancers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Preparation of cDNA from single cells and subcellular regions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

Understanding the biology of aging: the key to prevention and therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2899%2900202-X

10.1016/S0027-5107(99)00202-X

7 January 2021

Identifiers

DOI

1 reference

29 July 2017

1 reference