(Q40534487)

English

Kaposi's sarcoma-associated herpesvirus-encoded viral interleukin-6 is secreted and modified differently than human interleukin-6: evidence for a unique autocrine signaling mechanism

scientific article published on 16 July 2004

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scholarly article

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Europe PubMed Central

21 September 2017

Kaposi's sarcoma-associated herpesvirus-encoded viral interleukin-6 is secreted and modified differently than human interleukin-6: evidence for a unique autocrine signaling mechanism (English)

1 reference

Europe PubMed Central

21 September 2017

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Peter G Medveczky

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Peter G Medveczky

2

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author name string

Mark B Meads

1

1 reference

Europe PubMed Central

21 September 2017

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publication date

16 July 2004

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Europe PubMed Central

21 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

21 September 2017

279

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Europe PubMed Central

21 September 2017

50

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Europe PubMed Central

21 September 2017

51793-51803

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Europe PubMed Central

21 September 2017

Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma

1 reference

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Stat3 as an oncogene

1 reference

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21 January 2018

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

1 reference

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21 January 2018

Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo

1 reference

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Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

1 reference

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21 January 2018

Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma

1 reference

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21 January 2018

Human herpesvirus 8 (HHV-8)-encoded cytokines induce expression of and autocrine signaling by vascular endothelial growth factor (VEGF) in HHV-8-infected primary-effusion lymphoma cell lines and mediate VEGF-independent antiapoptotic effects

1 reference

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21 January 2018

Increased expression of vascular endothelial growth factor (VEGF) in Castleman's disease: proposed pathomechanism of vascular proliferation in the affected lymph node

1 reference

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21 January 2018

Heterogeneity of viral IL-6 expression in HHV-8-associated diseases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

Inactivation of the IL-6 gene prevents development of multicentric Castleman's disease in C/EBP beta-deficient mice

1 reference

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21 January 2018

A detergent-free method for purifying caveolae membrane from tissue culture cells

1 reference

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Constitutive cytokine production by primary effusion (body cavity-based) lymphoma-derived cell lines

1 reference

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21 January 2018

Human herpesvirus 8-encoded interleukin-6 homologue (viral IL-6) induces endogenous human IL-6 secretion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders

1 reference

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21 January 2018

A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

Structure of an extracellular gp130 cytokine receptor signaling complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

Human herpes virus 8 interleukin-6 homologue triggers gp130 on neuronal and hematopoietic cells

1 reference

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21 January 2018

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

Molecular cloning and expression of an IL-6 signal transducer, gp130

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

Viral IL-6-induced cell proliferation and immune evasion of interferon activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

Characterization of glycoproteins and their associated oligosaccharides through the use of endoglycosidases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

Brefeldin A: the advantage of being uncompetitive

1 reference

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21 January 2018

Protein glycosylation: nature, distribution, enzymatic formation, and disease implications of glycopeptide bonds

1 reference

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21 January 2018

Glycosylation of interleukin-6 purified from normal human blood mononuclear cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

Eukaryotic protein secretion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

Marked cell-type-specific differences in glycosylation of human interleukin-6

1 reference

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21 January 2018

Interleukin-6: structure-function relationships.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

Improvement in the heterogeneous N-termini and the defective N-glycosylation of human interleukin-6 by genetic engineering

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

Mannose receptor-mediated regulation of serum glycoprotein homeostasis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

Biosynthesis and N-glycosylation of human interferon-gamma. Asn25 and Asn97 differ markedly in how efficiently they are glycosylated and in their oligosaccharide composition.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

Secretory IgA N- and O-glycans provide a link between the innate and adaptive immune systems

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites

1 reference

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21 January 2018

Unique biochemical nature of carp retinol-binding protein. N-linked glycosylation and uncleavable NH2-terminal signal peptide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

Signal sequences. The limits of variation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

Functions of signal and signal-anchor sequences are determined by the balance between the hydrophobic segment and the N-terminal charge

1 reference

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21 January 2018

The transmembrane domain of influenza hemagglutinin exhibits a stringent length requirement to support the hemifusion to fusion transition

1 reference

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21 January 2018

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

1 reference

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21 January 2018

Transformation by v-sis occurs by an internal autoactivation mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

Autocrine stimulation by the v-sis gene product requires a ligand-receptor interaction at the cell surface

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

N-linked glycosylation is required for optimal function of Kaposi's sarcoma herpesvirus-encoded, but not cellular, interleukin 6

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407382200

21 January 2018

Determination of the Disulfide Structure andN-Glycosylation Sites of the Extracellular Domain of the Human Signal Transducer gp130

1 reference

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21 January 2018

O - and N -glycosylation lead to different molecular mass forms of human monocyte interleukin-6

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M407382200

1 reference

Europe PubMed Central

21 September 2017

1 reference

Europe PubMed Central

21 September 2017

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