(Q40564428)

21 September 2017

title

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons (English)

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Membrane metalloendopeptidase

21 September 2017

main subject

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amyloid-beta clearance by cellular catabolic process

GOA release 2020-03-11

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GOA release 2020-03-11

author name string

Emi Hama

1

1 reference

21 September 2017

Keiro Shirotani

2

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21 September 2017

Nobuhisa Iwata

3

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21 September 2017

Takaomi C Saido

4

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21 September 2017

language of work or name

English

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publication date

20 April 2004

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Journal of Biological Chemistry

21 September 2017

published in

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21 September 2017

volume

279

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21 September 2017

issue

29

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21 September 2017

page(s)

30259-30264

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Amyloid, the presenilins and Alzheimer's disease

21 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401891200

Metabolic regulation of brain Abeta by neprilysin

21 January 2018

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Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

21 January 2018

1 reference

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Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo

21 January 2018

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Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme

21 January 2018

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21 January 2018

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Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401891200

Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide

21 January 2018

1 reference

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Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain

21 January 2018

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Intracellular A-beta amyloid, a sign for worse things to come?

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M401891200

Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer's disease

21 January 2018

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A fluid connection: cholesterol and Abeta

21 January 2018

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Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401891200

Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons

21 January 2018

1 reference

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Endoplasmic reticulum localization of Sec12p is achieved by two mechanisms: Rer1p-dependent retrieval that requires the transmembrane domain and Rer1p-independent retention that involves the cytoplasmic domain.

21 January 2018

1 reference

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Association of GAP-43 with detergent-resistant membranes requires two palmitoylated cysteine residues

21 January 2018

1 reference

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Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401891200

Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401891200

Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401891200

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

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Role of the glycosyl-phosphatidylinositol anchor in the intracellular transport of a transmembrane protein in Madin-Darby canine kidney cells

21 January 2018

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Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

21 January 2018

1 reference

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Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology

21 January 2018

1 reference

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Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.

21 January 2018

1 reference

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Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401891200

Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice

21 January 2018

1 reference

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Early intraneuronal Abeta deposition in the hippocampus of APP transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401891200

Endoplasmic reticulum-localized amyloid beta-peptide is degraded in the cytosol by two distinct degradation pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401891200

An immunoelectron microscopic study of pig substantia nigra shows co-localization of endopeptidase-24.11 with substance P.

21 January 2018

1 reference

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Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401891200

GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401891200

Interactions of amyloid beta-protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401891200

Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401891200

Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401891200

21 January 2018

Identifiers

DOI

10.1074/JBC.M401891200

1 reference

21 September 2017

1 reference