(Q40571808)

21 September 2017

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title

M2-based influenza vaccines: recent advances and clinical potential (English)

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21 September 2017

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4

Xavier Saelens

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21 September 2017

2

Bert Schepens

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21 September 2017

3

Walter Fiers

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21 September 2017

Annasaheb Kolpe

1

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21 September 2017

publication date

22 September 2016

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Expert Review of Vaccines

21 September 2017

published in

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21 September 2017

volume

16

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21 September 2017

issue

2

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21 September 2017

page(s)

123-136

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A Virus Obtained from Influenza Patients

21 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

RESULTS OF IMMUNIZATION BY MEANS OF ACTIVE VIRUS OF HUMAN INFLUENZA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Advances in the development of influenza virus vaccines.

21 January 2018

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https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

A distinct lineage of influenza A virus from bats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

New world bats harbor diverse influenza A viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Pandemic versus epidemic influenza mortality: a pattern of changing age distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

An update on swine-origin influenza virus A/H1N1: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Identification of a second protein (M2) encoded by RNA segment 7 of influenza virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Sequences of mRNAs derived from genome RNA segment 7 of influenza virus: colinear and interrupted mRNAs code for overlapping proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Selective proton permeability and pH regulation of the influenza virus M2 channel expressed in mouse erythroleukaemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Influenza virus M2 protein has ion channel activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Proton and cation transport activity of the M2 proton channel from influenza A virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Stepwise priming by acidic pH and a high K+ concentration is required for efficient uncoating of influenza A virus cores after penetration

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Unpacking the incoming influenza virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Supplementation of H1N1pdm09 split vaccine with heterologous tandem repeat M2e5x virus-like particles confers improved cross-protection in ferrets

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Development of a candidate influenza vaccine based on virus-like particles displaying influenza M2e peptide into the immunodominant region of hepatitis B core antigen: Broad protective efficacy of particles carrying four copies of M2e.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Antibody response to the M2 protein of influenza A virus expressed in insect cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Serum antibody response to matrix protein 2 following natural infection with 2009 pandemic influenza A(H1N1) virus in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Structure of the extracellular domain of matrix protein 2 of influenza A virus in complex with a protective monoclonal antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Natural and long-lasting cellular immune responses against influenza in the M2e-immune host

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

A universal influenza A vaccine based on the extracellular domain of the M2 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Virus-like particles containing multiple M2 extracellular domains confer improved cross-protection against various subtypes of influenza virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

An influenza A vaccine based on tetrameric ectodomain of matrix protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

CTA1-M2e-DD: a novel mucosal adjuvant targeted influenza vaccine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Protection against Influenza A Virus Challenge with M2e-Displaying Filamentous Escherichia coli Phages

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Recombinant M2e outer membrane vesicle vaccines protect against lethal influenza A challenge in BALB/c mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Matrix protein 2 vaccination and protection against influenza viruses, including subtype H5N1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

MVA vectors expressing conserved influenza proteins protect mice against lethal challenge with H5N1, H9N2 and H7N1 viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Vaccination with recombinant 4 × M2e.HSP70c fusion protein as a universal vaccine candidate enhances both humoral and cell-mediated immune responses and decreases viral shedding against experimental challenge of H9N2 influenza in chickens

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Efficient induction of mucosal and systemic immune responses by virus-like particles administered intranasally: implications for vaccine design

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Immunization with M2e-displaying T7 bacteriophage nanoparticles protects against influenza A virus challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Comparative immunogenicity evaluations of influenza A virus M2 peptide as recombinant virus like particle or conjugate vaccines in mice and monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Protection against H1, H5, H6 and H9 influenza A infection with liposomal matrix 2 epitope vaccines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Protection against influenza A virus by vaccination with a recombinant fusion protein linking influenza M2e to human serum albumin (HSA).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Synthesis and Immunogenicity Assessment of Elastin-Like Polypeptide-M2e Construct as an Influenza Antigen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Development of a heat-stable and orally delivered recombinant M2e-expressing B. subtilis spore-based influenza vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Protective efficacy of a bacterially produced modular capsomere presenting M2e from influenza: extending the potential of broadly cross-protecting epitopes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

A molecular assembly system for presentation of antigens on the surface of HBc virus-like particles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

A novel subnucleocapsid nanoplatform for mucosal vaccination against influenza virus that targets the ectodomain of matrix protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Universal influenza A vaccine: optimization of M2-based constructs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

The universal influenza vaccine M2e-HBc administered intranasally in combination with the adjuvant CTA1-DD provides complete protection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

The co-administration of CpG-ODN influenced protective activity of influenza M2e vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Increased immunogenicity and protective efficacy of influenza M2e fused to a tetramerizing protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Universal vaccine based on ectodomain of matrix protein 2 of influenza A: Fc receptors and alveolar macrophages mediate protection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Fc receptor is not required for inducing antibodies but plays a critical role in conferring protection after influenza M2 vaccination

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody-dependent NK cell activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Therapeutic potential of a fully human monoclonal antibody against influenza A virus M2 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Supplementation of influenza split vaccines with conserved M2 ectodomains overcomes strain specificity and provides long-term cross protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

AS04-adjuvanted virus-like particles containing multiple M2 extracellular domains of influenza virus confer improved protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Safety and immunogenicity of a recombinant M2e-flagellin influenza vaccine (STF2.4xM2e) in healthy adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Vaccination inducing broad and improved cross protection against multiple subtypes of influenza A virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Influenza virus-like particles containing M2 induce broadly cross protective immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Plasmid DNA-based vaccines protect mice and ferrets against lethal challenge with A/Vietnam/1203/04 (H5N1) influenza virus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Preclinical study of influenza virus A M2 peptide conjugate vaccines in mice, ferrets, and rhesus monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Development of a universal influenza A vaccine based on the M2e peptide fused to the papaya mosaic virus (PapMV) vaccine platform.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Tandem repeats of the extracellular domain of Matrix 2 influenza protein exposed in Brucella lumazine synthase decameric carrier molecule induce protection in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

A novel M2e based flu vaccine formulation for dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Vaccination of pigs with a DNA construct expressing an influenza virus M2-nucleoprotein fusion protein exacerbates disease after challenge with influenza A virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Immunogenicity and protective efficacy of candidate universal influenza A nanovaccines produced in plants by Tobacco mosaic virus-based vectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

A lipopeptide based on the M2 and HA proteins of influenza A viruses induces protective antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Vaccination with M2e-based multiple antigenic peptides: characterization of the B cell response and protection efficacy in inbred and outbred mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

DNA-vaccine platform development against H1N1 subtype of swine influenza A viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Complete protection against a H5N2 avian influenza virus by a DNA vaccine expressing a fusion protein of H1N1 HA and M2e.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Immunogenicity of live attenuated B. pertussis BPZE1 producing the universal influenza vaccine candidate M2e.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Human antibodies reveal a protective epitope that is highly conserved among human and nonhuman influenza A viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Monoclonal antibodies recognizing EVETPIRN epitope of influenza A virus M2 protein could protect mice from lethal influenza A virus challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Nucleotide sequences of influenza A virus RNA segment 7: a comparison of five isolates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Effects of antibody to the influenza A virus M2 protein on M2 surface expression and virus assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Evidence for phagocytosis of influenza virus-infected, apoptotic cells by neutrophils and macrophages in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Fc receptor-mediated phagocytosis makes a significant contribution to clearance of influenza virus infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Influenza type A virus escape mutants emerge in vivo in the presence of antibodies to the ectodomain of matrix protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

FcgammaRIV: a novel FcR with distinct IgG subclass specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Fcgamma receptors as regulators of immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Characterizations of four monoclonal antibodies against M2 protein ectodomain of influenza A virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

A Human Anti-M2 Antibody Mediates Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Cytokine Secretion by Resting and Cytokine-Preactivated Natural Killer (NK) Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Cross-reactive influenza-specific antibody-dependent cellular cytotoxicity antibodies in the absence of neutralizing antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Antibody-dependent cellular cytotoxicity is associated with control of pandemic H1N1 influenza virus infection of macaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Identification of dominant antibody-dependent cell-mediated cytotoxicity epitopes on the hemagglutinin antigen of pandemic H1N1 influenza virus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Broadly neutralizing hemagglutinin stalk-specific antibodies require FcγR interactions for protection against influenza virus in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

A "universal" human influenza A vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Characterization of immunity induced by M2e of influenza virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Divergent immunoglobulin g subclass activity through selective Fc receptor binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

A lipidated form of the extracellular domain of influenza M2 protein as a self-adjuvanting vaccine candidate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

A Novel Vaccination Strategy Mediating the Induction of Lung-Resident Memory CD8 T Cells Confers Heterosubtypic Immunity against Future Pandemic Influenza Virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Efficacy and safety of treatment with an anti-m2e monoclonal antibody in experimental human influenza

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

A mouse model for the study of contact-dependent transmission of influenza A virus and the factors that govern transmissibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Mucosal immunization with a candidate universal influenza vaccine reduces virus transmission in a mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Effector CD4+ and CD8+ T-cell mechanisms in the control of respiratory virus infections.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Dynamics of human respiratory virus-specific CD8+ T cell responses in blood and airways during episodes of common cold.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Human memory CTL response specific for influenza A virus is broad and multispecific

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Induction of influenza type A virus-specific resistance by immunization of mice with a synthetic multiple antigenic peptide vaccine that contains ectodomains of matrix protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Recombinant baculovirus vaccine containing multiple M2e and adjuvant LTB induces T cell dependent, cross-clade protection against H5N1 influenza virus in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Synthetic multi-epitope peptides identified in silico induce protective immunity against multiple influenza serotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Universal vaccine against influenza virus: linking TLR signaling to anti-viral protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

A universal influenza A vaccine based on adenovirus expressing matrix-2 ectodomain and nucleoprotein protects mice from lethal challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Prospects for universal influenza virus vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Rapid high-yield expression of a candidate influenza vaccine based on the ectodomain of M2 protein linked to flagellin in plants using viral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Production of H5N1 Influenza Virus Matrix Protein 2 Ectodomain Protein Bodies in Tobacco Plants and in Insect Cells as a Candidate Universal Influenza Vaccine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Influenza virus hemagglutinin stalk-based antibodies and vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Recent changes among human influenza viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Universal influenza B vaccine based on the maturational cleavage site of the hemagglutinin precursor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

Identification of Hemagglutinin Residues Responsible for H3N2 Antigenic Drift during the 2014-2015 Influenza Season

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14760584.2017.1240041

10.1080/14760584.2017.1240041

21 January 2018

Identifiers

DOI

1 reference

21 September 2017

1 reference