(Q40584637)

English

The Knife's Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism but With a Significant Risk of CMV Reactivation and Disease in Rhesus Macaques

scientific article published on 8 August 2016

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scholarly article

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Europe PubMed Central

PMC publication ID

6 March 2018

http://europepmc.org/abstract/PMC/5338742

The Knife's Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism but With a Significant Risk of CMV Reactivation and Disease in Rhesus Macaques (English)

1 reference

Europe PubMed Central

PMC publication ID

6 March 2018

http://europepmc.org/abstract/PMC/5338742

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12 June 2020

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12 June 2020

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12 June 2020

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B R Blazar

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12 June 2020

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B Watkins

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12 June 2020

S Yu

4

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12 June 2020

D Tran

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12 June 2020

K Zeleski

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12 June 2020

K Singh

8

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12 June 2020

K Hamby

9

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12 June 2020

C Hotchkiss

10

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12 June 2020

J Lane

11

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12 June 2020

A B Adams

13

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12 June 2020

A D Kirk

15

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12 June 2020

A Kaur

16

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12 June 2020

C P Larsen

18

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12 June 2020

L S Kean

19

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12 June 2020

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publication date

8 August 2016

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Europe PubMed Central

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6 March 2018

http://europepmc.org/abstract/PMC/5338742

American Journal of Transplantation

1 reference

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12 June 2020

17

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12 June 2020

3

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Europe PubMed Central

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12 June 2020

657-670

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27500470%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Immune reconstitution/immunocompetence in recipients of kidney plus hematopoietic stem/facilitating cell transplants

1 reference

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17 June 2018

Belatacept and sirolimus prolong nonhuman primate renal allograft survival without a requirement for memory T cell depletion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Belatacept and sirolimus prolong nonhuman primate islet allograft survival: adverse consequences of concomitant alefacept therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Tolerance induction in HLA disparate living donor kidney transplantation by donor stem cell infusion: durable chimerism predicts outcome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Evidence for kidney rejection after combined bone marrow and renal transplantation despite ongoing whole-blood chimerism in rhesus macaques.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Induced immune tolerance for kidney transplantation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHC-defined rhesus macaque transplant model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Translational studies in hematopoietic cell transplantation: treatment of hematologic malignancies as a stepping stone to tolerance induction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Acute renal endothelial injury during marrow recovery in a cohort of combined kidney and bone marrow allografts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Allogeneic hematopoietic stem cell transplantation for sickle cell disease: the time is now.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Mixed chimerism, lymphocyte recovery, and evidence for early donor-specific unresponsiveness in patients receiving combined kidney and bone marrow transplantation to induce tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

An MHC-Defined Primate Model Reveals Significant Rejection of Bone Marrow After Mixed Chimerism Induction Despite Full MHC Matching

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Transplantation tolerance through mixed chimerism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Allogeneic hematopoietic stem-cell transplantation for sickle cell disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Relationship between mixed chimerism and rejection after bone marrow transplantation in thalassaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Tolerance and chimerism after renal and hematopoietic-cell transplantation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

HLA-mismatched renal transplantation without maintenance immunosuppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Reduced-intensity conditioning followed by allogeneic hematopoietic cell transplantation for adult patients with myelodysplastic syndrome and myeloproliferative disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Depletion of CD8+ cells in sooty mangabey monkeys naturally infected with simian immunodeficiency virus reveals limited role for immune control of virus replication in a natural host species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

The transplantation of hematopoietic stem cells after non-myeloablative conditioning: a cellular therapeutic approach to hematologic and genetic diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Mechanisms of tolerance induction through the transplantation of donor hematopoietic stem cells: central versus peripheral tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Direct Relationship between Suppression of Virus-Specific Immunity and Emergence of Cytomegalovirus Disease in Simian AIDS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Decreased frequency of cytomegalovirus (CMV)-specific CD4+ T lymphocytes in simian immunodeficiency virus-infected rhesus macaques: inverse relationship with CMV viremia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Hematopoietic cell transplantation for the induction of allo- and xenotolerance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Characterization of mixed allogeneic chimeras. Immunocompetence, in vitro reactivity, and genetic specificity of tolerance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

17 June 2018

Influence of dimethyl myleran on tolerance induction and immune function in major histocompatibility complex-haploidentical murine bone-marrow transplantation

1 reference

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17 June 2018

Multi-step pathogenesis of AIDS — role of cytomegalovirus

1 reference

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17 June 2018

Increasing mixed chimerism and the risk of graft loss in children undergoing allogeneic hematopoietic stem cell transplantation for non-malignant disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5338742

20 August 2018

Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment

1 reference

https://api.crossref.org/works/10.1111%2FAJT.14006

21 January 2018

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

2 references

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4 November 2018

https://api.crossref.org/works/10.1111%2FAJT.14006

21 January 2018

CTLA4Ig combined with anti-LFA-1 prolongs cardiac allograft survival indefinitely

1 reference

https://pubmed.ncbi.nlm.nih.gov/27500470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism by which additional monoclonal antibody (mAB) injections overcome the requirement for thymic irradiation to achieve mixed chimerism in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body

1 reference

https://pubmed.ncbi.nlm.nih.gov/27500470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of cadaveric renal transplant recipients with total lymphoid irradiation, antithymocyte globulin, and low-dose prednisone

1 reference

https://pubmed.ncbi.nlm.nih.gov/27500470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Costimulatory blockade for induction of mixed chimerism and renal allograft tolerance in nonhuman primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/27500470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD154 blockade for induction of mixed chimerism and prolonged renal allograft survival in nonhuman primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/27500470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modifications of the conditioning regimen for achieving mixed chimerism and donor-specific tolerance in cynomolgus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/27500470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning

1 reference

https://pubmed.ncbi.nlm.nih.gov/27500470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of chimerism in rhesus macaques through stem cell transplant and costimulation blockade-based immunosuppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/27500470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissociation of hemopoietic chimerism and allograft tolerance after allogeneic bone marrow transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/27500470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of tolerance by mixed chimerism with nonmyeloblative host conditioning: the importance of overcoming intrathymic alloresistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/27500470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting edge: administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning

1 reference

https://pubmed.ncbi.nlm.nih.gov/27500470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/27500470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mixed chimerism and transplantation tolerance induced by a nonlethal preparative regimen in cynomolgus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/27500470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a nonmyeloablative regimen

1 reference

https://pubmed.ncbi.nlm.nih.gov/27500470

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/AJT.14006

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27500470%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27500470%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27500470%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

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