(Q40607042)

English

Sphingosine-1-phosphate, a novel second messenger involved in cell growth regulation and signal transduction, affects growth and invasiveness of human breast cancer cells

scientific article published on January 1994

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

1 reference

Europe PubMed Central

Sphingosine-1-phosphate, a novel second messenger involved in cell growth regulation and signal transduction, affects growth and invasiveness of human breast cancer cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

neoplastic invasiveness

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Erik W. Thompson

4

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

author name string

S Spiegel

1

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

A Olivera

2

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

H Zhang

3

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Y Su

5

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

A Berger

6

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

language of work or name

0 references

publication date

1 January 1994

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Breast Cancer Research and Treatment

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

31

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

2-3

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

337-348

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

https://scigraph.springernature.com/pub.10.1007/bf00666166

0 references

Signal transduction by the platelet-derived growth factor receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functions of sphingolipids and sphingolipid breakdown products in cellular regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible involvement of a GTP-binding protein, the substrate of islet-activating protein, in receptor-mediated signaling responsible for cell proliferation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipids containing polyunsaturated fatty acyl groups are mitogenic for normal mouse mammary epithelial cells in serum-free primary cell culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Properties and specificities of sphingosine kinase from blood platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell regulation by sphingosine and more complex sphingolipids

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of phosphatidic acid phosphohydrolase activity by sphingosine. Dual action of sphingosine in diacylglycerol signal termination

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A cytoplasmic protein inhibits the GTPase activity of H-Ras in a phospholipid-dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of GTPase activating protein upon ras is inhibited by mitogenically responsive lipids

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling through phosphatidylcholine breakdown.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of phospholipase C-gamma overexpression on PDGF-induced second messengers and mitogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of breast cancer cells by hormones and growth factors: effects on proliferation and basement membrane invasiveness

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells. Synthesis via ceramide from sphingomyelin

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gangliosides as bimodal regulators of cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca2+-mobilizing actions of platelet-derived growth factor differ from those of bombesin and vasopressin in Swiss 3T3 mouse cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of phospholipase D-derived diradylglycerol in the activation of the human neutrophil respiratory burst oxidase. Inhibition by phosphatidic acid phosphohydrolase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of growth and invasiveness of MCF-7 breast cancer cells by antiestrogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A ligand for the erbB-2 oncogene product (gp30) induces differentiation of human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidic acid modulates DNA synthesis, phospholipase C, and platelet-derived growth factor mRNAs in cultured mesangial cells. Role of protein kinase C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of growth control in normal and malignant breast epithelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of long-chain (sphingoid) base biosynthesis in intact LM cells: effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sphingosine inhibits phosphatidate phosphohydrolase in human neutrophils by a protein kinase C-independent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of sphingosine and phorbol ester on the signal transduction enzymes and fibronectin release in cell culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of phospholipase D by sphingoid bases in NG108-15 neural-derived cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The bimodal growth response of Swiss 3T3 cells to the B subunit of cholera toxin is independent of the density of its receptor, ganglioside GM1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipase D in cell signalling and its relationship to phospholipase C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular ras activity and phospholipid metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ganglioside GM1 and sphingolipid breakdown products in cellular proliferation and signal transduction pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple non-specific effects of sphingosine on adenylate cyclase and cyclic AMP accumulation in S49 lymphoma cells preclude its use as a specific inhibitor of protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of phosphoinositide hydrolysis in cultured astrocytes by sphingosine and psychosine

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the insulin receptor tyrosine kinase by sphingosine

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular calcium release mediated by sphingosine derivatives generated in cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MAP kinases: charting the regulatory pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increases in phosphatidic acid levels accompany sphingosine-stimulated proliferation of quiescent Swiss 3T3 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma membrane fractions from rat liver contain a phosphatidate phosphohydrolase distinct from that in the endoplasmic reticulum and cytosol

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inositol trisphosphate and calcium signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Programmed cell death induced by ceramide

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stereospecificity of sphingosine-induced intracellular calcium mobilization and cellular proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic vesicle ceramide kinase. A calcium-stimulated lipid kinase that co-purifies with brain synaptic vesicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sphingosine activation of protein kinases in Jurkat T cells. In vitro phosphorylation of endogenous protein substrates and specificity of action.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sphingosine activates cellular diacylglycerol kinase in intact Jurkat cells, a human T-cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of mammary epithelial cell growth in mice and rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-based in vitro assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth factors and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptide growth factors are multifunctional

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysophosphatidic acid is a chemoattractant for Dictyostelium discoideum amoebae.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influences of sphingosine on two-stage skin tumorigenesis in Sencar mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of sphingosine bases. XV. Enzymatic degradation of 4t-sphingenine 1-phosphate (sphingosine 1-phosphate) to 2t-hexadecen-1-al and ethanolamine phosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth factor-like action of phosphatidic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceramide stimulates epidermal growth factor receptor phosphorylation in A431 human epidermoid carcinoma cells. Evidence that ceramide may mediate sphingosine action

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effector interactions of p21ras

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7881110

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF00666166

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Dimensions Publication ID

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release_ookwyb3atfhubayu5gu6upt7zm

1 reference

https://api.fatcat.wiki/v0/release/ookwyb3atfhubayu5gu6upt7zm

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

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