(Q40609881)

22 September 2017

Mutant (R406W) human tau is hyperphosphorylated and does not efficiently bind microtubules in a neuronal cortical cell model (English)

1 reference

22 September 2017

Pavan K Krishnamurthy

series ordinal

1

1 reference

PubMed ID

14660557

22 September 2017

Gail V W Johnson

series ordinal

2

1 reference

PubMed ID

14660557

22 September 2017

language of work or name

English

0 references

publication date

2 December 2003

1 reference

Journal of Biological Chemistry

22 September 2017

1 reference

22 September 2017

279

1 reference

22 September 2017

9

1 reference

22 September 2017

7893-7900

1 reference

Frontotemporal dementia and parkinsonism linked to chromosome 17: a consensus conference. Conference Participants

22 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Tau protein pathology in neurodegenerative diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Neurodegenerative tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Tau is a candidate gene for chromosome 17 frontotemporal dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Phenotypic correlations in FTDP-17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Tau domains, phosphorylation, and interactions with microtubules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Missense tau mutations identified in FTDP-17 have a small effect on tau-microtubule interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

The tau mutation (val337met) disrupts cytoskeletal networks of microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Missense point mutations of tau to segregate with FTDP-17 exhibit site-specific effects on microtubule structure in COS cells: a novel action of R406W mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Pro-apoptotic effects of tau mutations in chromosome 17 frontotemporal dementia and parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Tau filament formation in transgenic mice expressing P301L tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Autosomal dominant dementia with widespread neurofibrillary tangles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Phenotypic variation in hereditary frontotemporal dementia with tau mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Early-onset, rapidly progressive familial tauopathy with R406W mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Stable expression in Chinese hamster ovary cells of mutated tau genes causing frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Conditionally Immortalized Neural Cell Lines: Potential Models for the Study of Neural Cell Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Efficient control of tetracycline-responsive gene expression from an autoregulated bi-directional expression vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

The distribution of tau in the mammalian central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Tau proteins with frontotemporal dementia-17 mutations have both altered expression levels and phosphorylation profiles in differentiated neuroblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Hyperosmotic stress-induced apoptosis and tau phosphorylation in human neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Glycogen synthase kinase 3beta phosphorylates tau at both primed and unprimed sites. Differential impact on microtubule binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Two neuronal cell lines expressing the myelin basic protein gene display differences in their in vitro survival and in their response to glia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

21 January 2018

Caspases: enemies within

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Processes induced by tau expression in Sf9 cells have an axon-like microtubule organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Overexpression of tau in a nonneuronal cell induces long cellular processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Tau assembly in inducible transfectants expressing wild-type or FTDP-17 tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Tau mutations cause frontotemporal dementias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

MAPK recruitment by beta-amyloid in organotypic hippocampal slice cultures depends on physical state and exposure time

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Reduced binding of protein phosphatase 2A to tau protein with frontotemporal dementia and parkinsonism linked to chromosome 17 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311203200

21 January 2018

Identifiers

DOI

10.1074/JBC.M311203200

1 reference

22 September 2017

1 reference

PubMed ID

14660557