(Q40610046)

22 September 2017

title

iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING. (English)

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22 September 2017

Wei-Wei Luo

1

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22 September 2017

Shu Li

2

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22 September 2017

Chen Li

3

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22 September 2017

Huan Lian

4

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22 September 2017

Qing Yang

5

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22 September 2017

Bo Zhong

6

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22 September 2017

Hong-Bing Shu

7

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22 September 2017

language of work or name

English

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publication date

18 July 2016

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22 September 2017

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22 September 2017

volume

17

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22 September 2017

issue

9

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22 September 2017

page(s)

1057-1066

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Pathogen recognition and innate immunity

22 September 2017

cites work

1 reference

Pattern recognition receptors and inflammation

21 January 2018

1 reference

Nucleic acid recognition by the innate immune system

21 January 2018

1 reference

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells

21 January 2018

1 reference

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

21 January 2018

1 reference

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

21 January 2018

1 reference

RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway

21 January 2018

1 reference

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

21 January 2018

1 reference

IFI16 is an innate immune sensor for intracellular DNA

21 January 2018

1 reference

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

21 January 2018

1 reference

LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection

21 January 2018

1 reference

21 January 2018

Immune sensing of DNA

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Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

21 January 2018

1 reference

Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects

21 January 2018

1 reference

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

21 January 2018

1 reference

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

21 January 2018

1 reference

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

21 January 2018

1 reference

The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation

21 January 2018

1 reference

The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA

21 January 2018

1 reference

TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination

21 January 2018

1 reference

The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING.

21 January 2018

1 reference

The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA

21 January 2018

1 reference

RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms

21 January 2018

1 reference

STING manifests self DNA-dependent inflammatory disease

21 January 2018

1 reference

Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations

21 January 2018

1 reference

Activated STING in a vascular and pulmonary syndrome

21 January 2018

1 reference

Rhomboid proteases and their biological functions

21 January 2018

1 reference

Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE

21 January 2018

1 reference

iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS

21 January 2018

1 reference

Emerging role of rhomboid family proteins in mammalian biology and disease

21 January 2018

1 reference

5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential

21 January 2018

1 reference

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

21 January 2018

1 reference

21 January 2018

1 reference

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

21 January 2018

1 reference

Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling

21 January 2018

1 reference

iRHOM2 is a critical pathogenic mediator of inflammatory arthritis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27428826

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NI.3510

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22 September 2017

1 reference