(Q40612967)

English

Transcriptional and posttranscriptional roles for p38 mitogen-activated protein kinase in upregulation of TNF-alpha expression by deoxynivalenol (vomitoxin).

scientific article published on December 2003

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scholarly article

1 reference

Europe PubMed Central

22 September 2017

Transcriptional and posttranscriptional roles for p38 mitogen-activated protein kinase in upregulation of TNF-alpha expression by deoxynivalenol (vomitoxin). (English)

1 reference

Europe PubMed Central

22 September 2017

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author name string

Yong-Joo Chung

1

1 reference

Europe PubMed Central

22 September 2017

Hui-Ren Zhou

2

1 reference

Europe PubMed Central

22 September 2017

James J Pestka

3

1 reference

Europe PubMed Central

22 September 2017

publication date

1 December 2003

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Europe PubMed Central

22 September 2017

Toxicology and Applied Pharmacology

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Europe PubMed Central

22 September 2017

193

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Europe PubMed Central

22 September 2017

2

1 reference

Europe PubMed Central

22 September 2017

188-201

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Europe PubMed Central

22 September 2017

Induction of cytokine mRNAs in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): relationship to toxin distribution and protein synthesis inhibition

1 reference

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Effects of vomitoxin (deoxynivalenol) and cycloheximide on IL-2, 4, 5 and 6 secretion and mRNA levels in murine CD4+ cells

1 reference

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A CAT reporter construct allows ultrasensitive estimation of TNF synthesis, and suggests that the TNF gene has been silenced in non-macrophage cell lines

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Immunomodulation by fungal toxins

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Regulation of tumour necrosis factor alpha mRNA stability by the mitogen-activated protein kinase p38 signalling cascade

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Decreased sensitivity of tristetraprolin-deficient cells to p38 inhibitors suggests the involvement of tristetraprolin in the p38 signaling pathway

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Mammalian MAP kinase signalling cascades

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AU-rich elements: characterization and importance in mRNA degradation

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Up-regulation of macrophage inflammatory protein-2 and complement 3A receptor by the trichothecenes deoxynivalenol and satratoxin G.

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Signal transduction by the JNK group of MAP kinases

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The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR.

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Elevated gene expression and production of interleukins 2, 4, 5, and 6 during exposure to vomitoxin (deoxynivalenol) and cycloheximide in the EL-4 thymoma

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TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

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HNS, a nuclear-cytoplasmic shuttling sequence in HuR

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A Mycoplasma fermentans-derived synthetic lipopeptide induces AP-1 and NF-kappaB activity and cytokine secretion in macrophages via the activation of mitogen-activated protein kinase pathways

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Non-macrocyclic trichothecenes

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Identification of TIAR as a protein binding to the translational regulatory AU-rich element of tumor necrosis factor alpha mRNA.

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Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction

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Ribotoxic stress response: activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the alpha-sarcin/ricin loop in the 28S rRNA.

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Endotoxin potentiation of trichothecene-induced lymphocyte apoptosis is mediated by up-regulation of glucocorticoids

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Effect of processing on Fusarium mycotoxins.

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Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation

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Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA.

1 reference

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7 January 2021

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Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability

1 reference

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The in vitro effects of trichothecenes on the immune system

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Vomitoxin-induced cyclooxygenase-2 gene expression in macrophages mediated by activation of ERK and p38 but not JNK mitogen-activated protein kinases

1 reference

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Superinduction of COX-2 mRNA by cycloheximide and interleukin-1beta involves increased transcription and correlates with increased NF-kappaB and JNK activation

1 reference

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Vomitoxin-mediated IL-2, IL-4, and IL-5 superinduction in murine CD4+ T cells stimulated with phorbol ester calcium ionophore: relation to kinetics of proliferation

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Flow cytometric analysis of the effects of in vitro exposure to vomitoxin (deoxynivalenol) on apoptosis in murine T, B and IgA+ cells

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Toxicology of deoxynivalenol (vomitoxin).

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Combinations of ERK and p38 MAPK inhibitors ablate tumor necrosis factor-alpha (TNF-alpha ) mRNA induction. Evidence for selective destabilization of TNF-alpha transcripts

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Modulation of IL-1beta, IL-6 and TNF-alpha secretion and mRNA expression by the trichothecene vomitoxin in the RAW 264.7 murine macrophage cell line

1 reference

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7 January 2021

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1 reference

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7 January 2021

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1 reference

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7 January 2021

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1 reference

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7 January 2021

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1 reference

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7 January 2021

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Differential cytokine mRNA expression in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): dose response and time course

1 reference

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1 reference

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1 reference

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1 reference

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Identifiers

10.1016/S0041-008X(03)00299-0

1 reference

Europe PubMed Central

22 September 2017

release_qanfxp27p5ei7jt2ii23wmecfy

1 reference

https://api.fatcat.wiki/v0/release/qanfxp27p5ei7jt2ii23wmecfy

24 November 2022

based on heuristic

mapped directly with Wikidata item

1 reference

Europe PubMed Central

22 September 2017

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