(Q40613643)

22 September 2017

Neutrophil elastase cleaves PML-RARalpha and is important for the development of acute promyelocytic leukemia in mice (English)

1 reference

acute promyelocytic leukemia

22 September 2017

1 reference

Andrew A Lane

1

1 reference

PubMed ID

14636558

22 September 2017

Timothy J Ley

series ordinal

2

1 reference

PubMed ID

14636558

22 September 2017

language of work or name

English

0 references

publication date

1 October 2003

1 reference

22 September 2017

1 reference

22 September 2017

115

1 reference

22 September 2017

305-318

1 reference

22 September 2017

3

1 reference

Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis

22 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Nucleocytoplasmic distribution of the ovalbumin serpin PI-9 requires a nonconventional nuclear import pathway and the export factor Crm1

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

A PMLRARalpha transgene initiates murine acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Transgenic expression of PML/RARalpha impairs myelopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Cell death induction by the acute promyelocytic leukemia-specific PML/RARalpha fusion protein

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Expression of the neutrophil elastase gene during human bone marrow cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Role of neutrophil elastase in bone marrow failure syndromes: molecular genetic revival of the chalone hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

The cleavage product deltaPML-RARalpha contributes to all-trans retinoic acid-mediated differentiation in acute promyelocytic leukemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice parallel human acute promyelocytic leukemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice identify cooperating events and genetic pathways to acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Analysis of the growth and transformation suppressor domains of promyelocytic leukemia gene, PML.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

PML-RAR induces promyelocytic leukemias with high efficiency following retroviral gene transfer into purified murine hematopoietic progenitors

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Mouse models of acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

A model of APL with FLT3 mutation is responsive to retinoic acid and a receptor tyrosine kinase inhibitor, SU11657.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Localization of granzyme B in the nucleus. A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

12-o-Tetradecanoyl-phorbol-13-acetate-differentiated U937 cells express a macrophage-like profile of neutral proteinases. High levels of secreted collagenase and collagenase inhibitor accompany low levels of intracellular elastase and cathepsin G.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARα expression

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RARalpha) and oncogenic RARalpha fusion proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900852-3

7 January 2021

10.1016/S0092-8674(03)00852-3

Identifiers

DOI

1 reference

22 September 2017

1 reference

PubMed ID

14636558