(Q40621790)

English

Large Dimeric Ligands with Favorable Pharmacokinetic Properties and Peroxisome Proliferator-Activated Receptor Agonist Activity in Vitro and in Vivo

scientific article published on November 6, 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Large dimeric ligands with favorable pharmacokinetic properties and peroxisome proliferator-activated receptor agonist activity in vitro and in vivo (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Large Dimeric Ligands with Favorable Pharmacokinetic Properties and Peroxisome Proliferator-Activated Receptor Agonist Activity in Vitro and in Vivo (English)

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

molecular medicine

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

pharmacokinetics

1 reference

based on heuristic

inferred from title

7

object named as

Jan Nehlin

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14584939

26 March 2024

author name string

Per Sauerberg

1

1 reference

Europe PubMed Central

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22 September 2017

Heinz-Josef Deussen

4

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Ingrid Pettersson

5

1 reference

Europe PubMed Central

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22 September 2017

Jan Fleckner

6

1 reference

Europe PubMed Central

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22 September 2017

Tatjana Albrektsen

9

1 reference

Europe PubMed Central

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22 September 2017

Nanni Din

10

1 reference

Europe PubMed Central

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22 September 2017

Lars Ynddal

12

1 reference

Europe PubMed Central

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22 September 2017

Lone Jeppesen

14

1 reference

Europe PubMed Central

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22 September 2017

Paul S. Bury

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14584939

26 March 2024

John P. Mogensen

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14584939

26 March 2024

Klaus S. Frederiksen

8

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14584939

26 March 2024

L. Anders Svensson

11

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14584939

26 March 2024

Erik M. Wulff

13

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14584939

26 March 2024

language of work or name

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publication date

1 November 2003

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Europe PubMed Central

PubMed publication ID

22 September 2017

6 November 2003

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National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14584939

26 March 2024

full work available at URL

https://pubs.acs.org/doi/pdf/10.1021/jm0309046

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Journal of Medicinal Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

46

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Europe PubMed Central

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22 September 2017

23

1 reference

Europe PubMed Central

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22 September 2017

4883-4894

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

A systematic review of the clinical effectiveness of pioglitazone in the treatment of type 2 diabetes mellitus

2

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Clinical Therapeutics

3

24

396

author name string

Boyle P. J.

publication date

2002

1 reference

10.1021/JM0309046

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26 March 2024

Mechanism of action of fibrates on lipid and lipoprotein metabolism

4

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport

5

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

6

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family

8

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

A tailored therapy for the metabolic syndrome: the dual peroxisome proliferator-activated receptor-alpha/gamma agonist LY465608 ameliorates insulin resistance and diabetic hyperglycemia while improving cardiovascular risk factors in preclinical mode

9

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template

12

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar

14

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Journal of Organic Chemistry

17

65

1561

author name string

Takeuchi R.

publication date

2000

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Journal of Medicinal Chemistry

19

39

668

author name string

Willson T. M.

publication date

1996

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Journal of Pharmacology and Experimental Therapeutics

21

298

1268

author name string

Christopoulos A.

publication date

2001

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

22

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Crystal structure of the ligand binding domain of the human nuclear receptor PPARgamma

23

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

24

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Molecular properties that influence the oral bioavailability of drug candidates

25

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Drug transport proteins in the liver

26

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors

27

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation

28

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

A fast flexible docking method using an incremental construction algorithm.

29

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Evaluation of the FLEXX incremental construction algorithm for protein-ligand docking

30

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Placement of medium-sized molecular fragments into active sites of proteins.

31

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Multiple automatic base selection: protein-ligand docking based on incremental construction without manual intervention.

32

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Docking into knowledge-based potential fields: a comparative evaluation of DrugScore

33

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Consensus scoring for ligand/protein interactions

34

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

37

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Refinement of macromolecular structures by the maximum-likelihood method

39

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Structure of trypanothione reductase from Crithidia fasciculata at 2.6 A resolution; enzyme-NADP interactions at 2.8 A resolution

40

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Analysis of C alpha geometry in protein structures

41

1 reference

10.1021/JM0309046

https://api.crossref.org/works/10.1021/JM0309046

26 March 2024

Identifiers

10.1021/JM0309046

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

release_dpoee7cvcfewlgzam5rkwlktrm

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https://api.fatcat.wiki/v0/release/dpoee7cvcfewlgzam5rkwlktrm

24 November 2022

based on heuristic

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

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