(Q40627919)

22 September 2017

title

The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3 (English)

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206798

19 March 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14534538

signal transducing adaptor protein

19 March 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14534538

19 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206798

19 March 2024

author name string

Nieves Movilla

2

1 reference

22 September 2017

Irene Ischenko

3

1 reference

22 September 2017

Yehenew M. Agazie

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14534538

19 March 2024

Michael J. Hayman

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14534538

19 March 2024

language of work or name

English

0 references

publication date

1 October 2003

1 reference

22 September 2017

9 October 2003

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14534538

full work available at URL

19 March 2024

https://www.nature.com/articles/1206798.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14534538

https://www.nature.com/articles/1206798.pdf

19 March 2024

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206798

https://www.nature.com/articles/1206798

19 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206798

19 March 2024

1 reference

22 September 2017

volume

22

1 reference

22 September 2017

issue

44

1 reference

22 September 2017

page(s)

6909-6918

1 reference

Concomitant activation of the PI3K-Akt and the Ras-ERK signaling pathways is essential for transformation by the V-SEA tyrosine kinase oncogene

22 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

Development of an efficient "substrate-trapping" mutant of Src homology phosphotyrosine phosphatase 2 and identification of the epidermal growth factor receptor, Gab1, and three other proteins as target substrates

21 January 2018

1 reference

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Apert syndrome mutations in fibroblast growth factor receptor 2 exhibit increased affinity for FGF ligand

21 January 2018

1 reference

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Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype

21 January 2018

1 reference

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The enigma of ectopic expression of FGFR3 in multiple myeloma: a critical initiating event or just a target for mutational activation during tumor progression

21 January 2018

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Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma

21 January 2018

1 reference

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Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3

21 January 2018

1 reference

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A common requirement for the catalytic activity and both SH2 domains of SHP-2 in mitogen-activated protein (MAP) kinase activation by the ErbB family of receptors. A specific role for SHP-2 in map, but not c-Jun amino-terminal kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

Tyrosine kinase signalling in breast cancer: fibroblast growth factors and their receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases

21 January 2018

1 reference

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Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction

21 January 2018

1 reference

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Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

21 January 2018

1 reference

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Shp-2 mediates v-Src-induced morphological changes and activation of the anti-apoptotic protein kinase Akt.

21 January 2018

1 reference

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Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation

21 January 2018

1 reference

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Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

21 January 2018

1 reference

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Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction

21 January 2018

1 reference

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The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

Activation of FGF receptors by mutations in the transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

The transmembrane mutation G380R in fibroblast growth factor receptor 3 uncouples ligand-mediated receptor activation from down-regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

Ligand-independent activation of fibroblast growth factor receptors by point mutations in the extracellular, transmembrane, and kinase domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

Receptor specificity of the fibroblast growth factor family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

The tyrosines in the bidentate motif of the env-sea oncoprotein are essential for cell transformation and are binding sites for Grb2 and the tyrosine phosphatase SHP-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

Structural basis for FGF receptor dimerization and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

Activating mutations in the extracellular domain of the fibroblast growth factor receptor 2 function by disruption of the disulfide bond in the third immunoglobulin-like domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

Missense FGFR3 mutations create cysteine residues in thanatophoric dwarfism type I (TD1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

The SH2 tyrosine phosphatase shp2 is required for mammalian limb development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.

21 January 2018

1 reference

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Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

Cell cycle-dependent activation of Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

Novel fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer previously identified in non-lethal skeletal disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

Genetic analysis of protein tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

Enhanced signaling and morphological transformation by a membrane-localized derivative of the fibroblast growth factor receptor 3 kinase domain

21 January 2018

1 reference

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FGFR activation in skeletal disorders: too much of a good thing

21 January 2018

1 reference

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Genetics of craniofacial development and malformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome

21 January 2018

1 reference

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Saethre-Chotzen syndrome associated with balanced translocations involving 7p21: three further families

21 January 2018

1 reference

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Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

21 January 2018

1 reference

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The catalytic role of aspartic acid-92 in a human dual-specific protein-tyrosine-phosphatase

21 January 2018

1 reference

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7 January 2021

Fibroblast growth factor receptor 3 mutations promote apoptosis but do not alter chondrocyte proliferation in thanatophoric dysplasia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

7 January 2021

The fibroblast growth factor receptor-1 is necessary for the induction of neurite outgrowth in PC12 cells by aFGF.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

7 January 2021

Expression of basic fibroblast growth factor and fibroblast growth factor receptor in advanced gastric carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206798

7 January 2021

Patterson-Stevenson-Fontaine syndrome: 30-year follow-up and clinical details of a further affected case

51

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206798

A novel mutation in FGFR-3 disrupts a putative N-glycosylation site and results in hypochondroplasia

19 March 2024

56

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206798

19 March 2024

Identifiers

1 reference

Dimensions Publication ID

22 September 2017

1040464757

0 references

1 reference