(Q40629059)

22 September 2017

title

pRB contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2F activities (English)

1 reference

22 September 2017

pRB Contains an E2F1-Specific Binding Domain that Allows E2F1-Induced Apoptosis to Be Regulated Separately from Other E2F Activities (English)

1 reference

https://api.crossref.org/works/10.1016/S1097-2765(03)00344-7

18 March 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14527410

18 March 2024

1 reference

https://api.crossref.org/works/10.1016/S1097-2765(03)00344-7

18 March 2024

author name string

Nick Dyson

series ordinal

2

1 reference

22 September 2017

Frederick A. Dick

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14527410

18 March 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14527410

18 March 2024

publication date

1 September 2003

1 reference

full work available at URL

22 September 2017

http://www.cell.com/article/S1097276503003447/pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14527410

https://api.elsevier.com/content/article/PII:S1097276503003447?httpAccept=text/xml

18 March 2024

1 reference

https://api.crossref.org/works/10.1016/S1097-2765(03)00344-7

https://api.elsevier.com/content/article/PII:S1097276503003447?httpAccept=text/plain

18 March 2024

1 reference

https://api.crossref.org/works/10.1016/S1097-2765(03)00344-7

18 March 2024

1 reference

22 September 2017

volume

12

1 reference

22 September 2017

issue

3

1 reference

22 September 2017

page(s)

639-649

1 reference

Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor

22 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Retinoblastoma protein recruits histone deacetylase to repress transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

G1 cyclin/cyclin-dependent kinase-coordinated phosphorylation of endogenous pocket proteins differentially regulates their interactions with E2F4 and E2F1 and gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

The E2F transcription factor is a cellular target for the RB protein

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Mutant mouse models reveal the relative roles of E2F1 and E2F3 in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Distinct roles for E2F proteins in cell growth control and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Three regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

The regulation of E2F by pRB-family proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

E2F-1 functions in mice to promote apoptosis and suppress proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

pRB plays an essential role in cell cycle arrest induced by DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Increased levels of E2F-1-dependent DNA binding activity after UV- or gamma-irradiation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

E2F4 is essential for normal erythrocyte maturation and neonatal viability

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Role for the p53 homologue p73 in E2F-1-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

An integral membrane green fluorescent protein marker, Us9-GFP, is quantitatively retained in cells during propidium iodide-based cell cycle analysis by flow cytometry

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

E2F3 activity is regulated during the cell cycle and is required for the induction of S phase.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Retinoblastoma protein represses transcription by recruiting a histone deacetylase

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Identification of G1 kinase activity for cdk6, a novel cyclin D partner

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Apaf-1 is a transcriptional target for E2F and p53

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Induction of S-phase entry by E2F transcription factors depends on their nuclear localization

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Direct coupling of the cell cycle and cell death machinery by E2F.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Incomplete penetrance of familial retinoblastoma linked to germ-line mutations that result in partial loss of RB function

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Differential regulation of E2F1 apoptotic target genes in response to DNA damage.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Identification of a growth suppression domain within the retinoblastoma gene product

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

The transcription factor E2F-1 is a downstream target of RB action

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Chk2 activates E2F-1 in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Sibling rivalry in the E2F family

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

RB and hbrm cooperate to repress the activation functions of E2F1

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Target gene specificity of E2F and pocket protein family members in living cells

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Growth suppression by an E2F-binding-defective retinoblastoma protein (RB): contribution from the RB C pocket

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Tumor induction and tissue atrophy in mice lacking E2F-1

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2803%2900344-7

7 January 2021

Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation

series ordinal

31

1 reference

https://api.crossref.org/works/10.1016/S1097-2765(03)00344-7

18 March 2024

Identifiers

1 reference

22 September 2017

1 reference