(Q40680513)

English

Cooperative enhancement of insulinotropic action of GLP-1 by acetylcholine uncovers paradoxical inhibitory effect of beta cell muscarinic receptor activation on adenylate cyclase activity.

scientific article published on January 2003

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12504804%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

Cooperative enhancement of insulinotropic action of GLP-1 by acetylcholine uncovers paradoxical inhibitory effect of beta cell muscarinic receptor activation on adenylate cyclase activity (English)

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16 December 2019

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16 December 2019

Yasser H.A Abdel-Wahab

2

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16 December 2019

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João C Miguel

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16 December 2019

Brian D Green

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16 December 2019

Paulo C F Mathias

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16 December 2019

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1 January 2003

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16 December 2019

Biochemical Pharmacology

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16 December 2019

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16 December 2019

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16 December 2019

283-292

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16 December 2019

Autonomic regulation of islet hormone secretion--implications for health and disease

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The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia

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Nutritional implications of the cephalic-phase reflexes: endocrine responses

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7 January 2021

Glucagon-like peptide-1 but not glucagon-like peptide-2 stimulates insulin release from isolated rat pancreatic islets

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7 January 2021

New developments in the incretin concept

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Insulin secretion and clearance. Comparison after oral and intravenous glucose.

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7 January 2021

Dose-dependent effects of oral and intravenous glucose on insulin secretion and clearance in normal humans

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Cholinergic agonists prime the beta-cell to glucose stimulation

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7 January 2021

Cholinergic Modification of Glucose-Induced Biphasic Insulin Release in Vitro

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7 January 2021

Cephalic-phase insulin secretion in normal and pancreatic islet-transplanted rats.

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7 January 2021

Stimulation by glucose and carbamylcholine of phospholipase C in pancreatic islets

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7 January 2021

Muscarinic receptor subtypes in rat pancreatic islets: binding and functional studies

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7 January 2021

Oxotremorine-m potentiation of glucose-induced insulin release from rat islets involves M3 muscarinic receptors

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7 January 2021

Quantitative and functional characterization of muscarinic receptor subtypes in insulin-secreting cell lines and rat pancreatic islets.

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7 January 2021

Muscarinic receptor subtypes mediate stimulatory and paradoxical inhibitory effects on an insulin-secreting beta cell line

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7 January 2021

The molecular basis of muscarinic receptor diversity

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7 January 2021

Identification of a family of muscarinic acetylcholine receptor genes

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7 January 2021

Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

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7 January 2021

Atypical protein kinase C isozyme zeta mediates carbachol-stimulated insulin secretion in RINm5F cells

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7 January 2021

Molecular basis of receptor/G-protein-coupling selectivity

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7 January 2021

Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients.

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7 January 2021

No reactive hypoglycaemia in Type 2 diabetic patients after subcutaneous administration of GLP-1 and intravenous glucose

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7 January 2021

Glucagon-like peptide-1 infusion must be maintained for 24 h/day to obtain acceptable glycemia in type 2 diabetic patients who are poorly controlled on sulphonylurea treatment

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7 January 2021

Gut hormones as pharmaceuticals. From enteroglucagon to GLP-1 and GLP-2.

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7 January 2021

Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and reversible weight loss in both normal and obese rats.

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7 January 2021

Glucagon-Like Peptide 1(7-36) Amide Stimulates Exocytosis in Human Pancreatic -Cells by Both Proximal and Distal Regulatory Steps in Stimulus-Secretion Coupling

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7 January 2021

Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut

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7 January 2021

Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1.

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7 January 2021

Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells

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7 January 2021

Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37).

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7 January 2021

Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion.

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7 January 2021

Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice

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7 January 2021

A highly sensitive adenylate cyclase assay

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7 January 2021

Interactions between cholinergic agonists and enteric factors in the regulation of insulin secretion from isolated perifused rat islets.

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7 January 2021

Influence of glucagon-like peptide-1 on beta cell responsiveness

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7 January 2021

Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Galpha(s) and Galpha(i)/Galpha(o) activation.

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7 January 2021

Regulation of insulin secretion by phospholipase C.

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Regulation of insulin release by phospholipase C activation in mouse islets: differential effects of glucose and neurohumoral stimulation

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Identification of muscarinic receptor subtypes in RINm5F cells by means of polymerase chain reaction, subcloning, and DNA sequencing

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Carbachol restores insulin release in diabetic GK rat islets by mechanisms largely involving hydrolysis of diacylglycerol and direct interaction with the exocytotic machinery

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Differential coupling of muscarinic m2 and m3 receptors to adenylyl cyclases V/VI in smooth muscle. Concurrent M2-mediated inhibition via Galphai3 and m3-mediated stimulation via Gbetagammaq

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Identifiers

10.1016/S0006-2952(02)01482-X

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12504804%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12504804%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

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