(Q40694350)

22 September 2017

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title

Defining functional drug-interaction domains on topoisomerase II by exploiting mechanistic differences between drug classes (English)

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22 September 2017

Osheroff N

1

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22 September 2017

Corbett AH

series ordinal

2

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22 September 2017

Elsea SH

series ordinal

3

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22 September 2017

Westergaard M

series ordinal

4

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22 September 2017

publication date

1 January 1994

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Cancer Chemotherapy and Pharmacology

22 September 2017

published in

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22 September 2017

volume

34 Suppl

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22 September 2017

page(s)

S19-25

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Protein-associated deoxyribonucleic acid strand breaks in L1210 cells treated with the deoxyribonucleic acid intercalating agents 4'-(9-acridinylamino) methanesulfon-m-anisidide and adriamycin

22 September 2017

cites work

1 reference

12 December 2020

When good enzymes go bad: conversion of topoisomerase II to a cellular toxin by antineoplastic drugs

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12 December 2020

Catalytic function of DNA topoisomerase II.

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12 December 2020

DNA topoisomerase II from Drosophila melanogaster. Purification and physical characterization

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12 December 2020

Stabilization of the topoisomerase II-DNA cleavage complex by antineoplastic drugs: inhibition of enzyme-mediated DNA religation by 4'-(9-acridinylamino)methanesulfon-m-anisidide.

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12 December 2020

In vivo mapping of DNA topoisomerase II-specific cleavage sites on SV40 chromatin.

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12 December 2020

Altered catalytic activity of and DNA cleavage by DNA topoisomerase II from human leukemic cells selected for resistance to VM-26.

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12 December 2020

Effects of DNA intercalating agents on topoisomerase II induced DNA strand cleavage in isolated mammalian cell nuclei

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12 December 2020

Induction of mammalian topoisomerase II dependent DNA cleavage by nonintercalative flavonoids, genistein and orobol

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12 December 2020

Chronic oral etoposide in the treatment of lung cancer

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12 December 2020

Interaction of the antitumor drug 4'-(9-acridinylamino)methanesulfon-m-anisidide and related acridines with nucleic acids

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12 December 2020

DNA gyrase: structure and function.

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12 December 2020

Etoposide in the treatment of leukemias

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12 December 2020

DNA topoisomerase poisons as antitumor drugs

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12 December 2020

The production of chromosomal alterations in human lymphocytes by drugs known to interfere with the activity of DNA topoisomerase II. I. m-AMSA.

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12 December 2020

Inhibition of protein synthesis reduces the cytotoxicity of 4'-(9-acridinylamino)methanesulfon-m-anisidide without affecting DNA breakage and DNA topoisomerase II in a murine mastocytoma cell line

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12 December 2020

Inhibition of eukaryotic topoisomerase II by ultraviolet-induced cyclobutane pyrimidine dimers.

1 reference

12 December 2020

DNA binding by epipodophyllotoxins and N-acyl anthracyclines: implications for mechanism of topoisomerase II inhibition

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12 December 2020

A model for tumor cell killing by topoisomerase poisons.

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12 December 2020

In vivo exposure to four ellipticine derivatives with topoisomerase inhibitory activity results in chromosome clumping and sister chromatid exchange in murine bone marrow cells

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12 December 2020

Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide.

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12 December 2020

Identification of DNA topoisomerase II as an intracellular target of antitumor epipodophyllotoxins in simian virus 40-infected monkey cells

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12 December 2020

Effects of antineoplastic drugs on the post-strand-passage DNA cleavage/religation equilibrium of topoisomerase II.

1 reference

12 December 2020

DNA topoisomerase II from Drosophila melanogaster. Relaxation of supercoiled DNA.

1 reference

12 December 2020

Exploiting mechanistic differences between drug classes to define functional drug interaction domains on topoisomerase II. Evidence that several diverse DNA cleavage-enhancing agents share a common site of action on the enzyme

1 reference

12 December 2020

A pyrimido[1,6-a]benzimidazole that enhances DNA cleavage mediated by eukaryotic topoisomerase II: a novel class of topoisomerase II-targeted drugs with cytotoxic potential

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12 December 2020

The role of DNA topoisomerases in recombination and genome stability: a double-edged sword?

1 reference

12 December 2020

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note

1 reference

12 December 2020

Atypical multiple drug resistance in a human leukemic cell line selected for resistance to teniposide (VM-26).

1 reference

12 December 2020

Purification and characterization of an altered topoisomerase II from a drug-resistant Chinese hamster ovary cell line.

1 reference

12 December 2020

Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group

1 reference

12 December 2020

Identification of the breakage-reunion subunit of T4 DNA topoisomerase

1 reference

12 December 2020

Qualitative and quantitative aspects of intercalator-induced DNA strand breaks

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12 December 2020

Isolation of intercalator-dependent protein-linked DNA strand cleavage activity from cell nuclei and identification as topoisomerase II

1 reference

12 December 2020

Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage.

1 reference

12 December 2020

Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae

1 reference

12 December 2020

Cross-resistance of an amsacrine-resistant human leukemia line to topoisomerase II reactive DNA intercalating agents. Evidence for two topoisomerase II directed drug actions

1 reference

12 December 2020

DNA topoisomerase I and II in cancer chemotherapy: update and perspectives

1 reference

12 December 2020

Characterization of an amsacrine-resistant line of human leukemia cells. Evidence for a drug-resistant form of topoisomerase II.

1 reference

12 December 2020

1 reference

12 December 2020

Effects of topoisomerase II-targeted drugs on enzyme-mediated DNA cleavage and ATP hydrolysis: evidence for distinct drug interaction domains on topoisomerase II.

1 reference

12 December 2020

Stimulation of topoisomerase II mediated DNA cleavage at specific sequence elements by the 2-nitroimidazole Ro 15-0216.

1 reference

12 December 2020

Eukaryotic topoisomerases recognize nucleic acid topology by preferentially interacting with DNA crossovers

1 reference

12 December 2020

SV40 DNA replication intermediates: analysis of drugs which target mammalian DNA replication

1 reference

12 December 2020

The capture of a DNA double helix by an ATP-dependent protein clamp: a key step in DNA transport by type II DNA topoisomerases

1 reference

12 December 2020

Mitoxantrone: bluebeard for malignancies

1 reference

12 December 2020

Eukaryotic topoisomerase II. Characterization of enzyme turnover

1 reference

12 December 2020

Double strand DNA cleavage by type II DNA topoisomerase from Drosophila melanogaster

1 reference

12 December 2020

Role of the divalent cation in topoisomerase II mediated reactions.

1 reference

12 December 2020

Mode of action of topoisomerase II-targeting agents at a specific DNA sequence. Uncoupling the DNA binding, cleavage and religation events

1 reference

12 December 2020

DNA topoisomerases as anticancer drug targets

1 reference

12 December 2020

1 reference

12 December 2020

On the simultaneous binding of eukaryotic DNA topoisomerase II to a pair of double-stranded DNA helices

1 reference

12 December 2020

Formation and rejoining of deoxyribonucleic acid double-strand breaks induced in isolated cell nuclei by antineoplastic intercalating agents

1 reference

12 December 2020

Proteolysis patterns of epitopically labeled yeast DNA topoisomerase II suggest an allosteric transition in the enzyme induced by ATP binding

1 reference

12 December 2020

On the coupling between ATP usage and DNA transport by yeast DNA topoisomerase II.

1 reference

12 December 2020

Small deletion and insertion mutations induced by the topoisomerase II inhibitor teniposide in CHO cells and comparison with sites of drug-stimulated DNA cleavage in vitro

1 reference

12 December 2020

Altered formation of DNA in human cells treated with inhibitors of DNA topoisomerase II (etoposide and teniposide)

1 reference

12 December 2020

Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential

1 reference

12 December 2020

Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons

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12 December 2020

Cleavage of DNA by mammalian DNA topoisomerase II

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12 December 2020

Apoptosis induced by anticancer drugs

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12 December 2020

Biochemical basis for the interactions of type I and type II topoisomerases with DNA.

1 reference

12 December 2020

Protein-associated DNA breaks in cells treated with adriamycin or ellipticine

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12 December 2020

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12 December 2020

Identifiers

DOI

10.1007/BF00684859

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Dimensions Publication ID

22 September 2017

1050049522

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