(Q40694627)

English

Alpha-synuclein lowers p53-dependent apoptotic response of neuronal cells. Abolishment by 6-hydroxydopamine and implication for Parkinson's disease

scientific article published on 22 October 2002

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scholarly article

1 reference

Europe PubMed Central

22 September 2017

Alpha-synuclein lowers p53-dependent apoptotic response of neuronal cells. Abolishment by 6-hydroxydopamine and implication for Parkinson's disease (English)

1 reference

Europe PubMed Central

22 September 2017

apoptotic process

0 references

Parkinson's disease

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Cristine Alves da Costa

1

1 reference

Europe PubMed Central

22 September 2017

Frédéric Checler

4

1 reference

Europe PubMed Central

22 September 2017

author name string

Erwan Paitel

2

1 reference

Europe PubMed Central

22 September 2017

Bruno Vincent

3

1 reference

Europe PubMed Central

22 September 2017

language of work or name

0 references

publication date

22 October 2002

1 reference

Europe PubMed Central

22 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

22 September 2017

277

1 reference

Europe PubMed Central

22 September 2017

52

1 reference

Europe PubMed Central

22 September 2017

50980-50984

1 reference

Europe PubMed Central

22 September 2017

Parkinson disease: etiology, pathogenesis and future of gene therapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Alpha-synuclein in Lewy bodies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Dopaminergic neurons degenerate by apoptosis in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Alpha-synuclein and the Parkinson's disease-related mutant Ala53Thr-alpha-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Definition of a consensus binding site for p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

WAF1, a potential mediator of p53 tumor suppression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Aggregation of alpha-synuclein induced by the Cu,Zn-superoxide dismutase and hydrogen peroxide system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Increased expression of rat synuclein in the substantia nigra pars compacta identified by mRNA differential display in a model of developmental target injury.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Synuclein expression is decreased in rat substantia nigra following induction of apoptosis by intrastriatal 6-hydroxydopamine.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Enhanced effects of 6-hydroxydopamine on evoked overflow of striatal dopamine in aged rats

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

The reaction of nitric oxide with 6-hydroxydopamine: implications for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Clonal cell lines produced by infection of neocortical neuroblasts using multiple oncogenes transduced by retroviruses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Intraneuronal Lewy body inclusions in Parkinson and diffuse Lewy body disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Autoxidation and Neurotoxicity of 6-Hydroxydopamine in the Presence of Some Antioxidants

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by intrastriatal injection of 6-hydroxydopamine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Mass fragmentography of dopamine and 6-hydroxydopamine. Application to the determination of dopamine in human brain biopsies from the caudate nucleus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207825200

21 January 2018

Identifiers

10.1074/JBC.M207825200

1 reference

Europe PubMed Central

22 September 2017

1 reference

Europe PubMed Central

22 September 2017

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