(Q40697370)

22 September 2017

Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines (English)

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22 September 2017

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7

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22 September 2017

Shunichi Takeda

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author name string

Sarah J Cumbers

1

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22 September 2017

Gareth T Williams

2

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22 September 2017

Sarah L Davies

3

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22 September 2017

Richard L Grenfell

4

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22 September 2017

Facundo D Batista

6

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22 September 2017

Michael S Neuberger

8

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22 September 2017

15 October 2002

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22 September 2017

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22 September 2017

20

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22 September 2017

1129-1134

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22 September 2017

11

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https://scigraph.springernature.com/pub.10.1038/nbt752

22 September 2017

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Making antibodies by phage display technology

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In vitro selection and affinity maturation of antibodies from a naive combinatorial immunoglobulin library

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7 January 2021

Mimicking somatic hypermutation: affinity maturation of antibodies displayed on bacteriophage using a bacterial mutator strain

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7 January 2021

Improving antibody affinity by mimicking somatic hypermutation in vitro

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7 January 2021

Picomolar affinity antibodies from a fully synthetic naive library selected and evolved by ribosome display

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7 January 2021

Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity

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7 January 2021

Isolation of picomolar affinity anti-c-erbB-2 single-chain Fv by molecular evolution of the complementarity determining regions in the center of the antibody binding site

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7 January 2021

TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line

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7 January 2021

Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation

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7 January 2021

A comparative analysis of the immunological evolution of antibody 28B4

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7 January 2021

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots

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7 January 2021

Conformational isomerism and the diversity of antibodies

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7 January 2021

Cell lines derived from avian lymphomas exhibit two distinct phenotypes

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7 January 2021

Increased ratio of targeted to random integration after transfection of chicken B cell lines.

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7 January 2021

A repertoire of monoclonal antibodies with human heavy chains from transgenic mice

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7 January 2021

The diversity of antigen-specific monoclonal antibodies from transgenic mice bearing human immunoglobulin gene miniloci

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7 January 2021

Antigen-specific human antibodies from mice comprising four distinct genetic modifications

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7 January 2021

High-avidity human IgG kappa monoclonal antibodies from a novel strain of minilocus transgenic mice.

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7 January 2021

Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities

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7 January 2021

Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.

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7 January 2021

Antibody modeling: implications for engineering and design.

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7 January 2021

Identifiers

DOI

10.1038/NBT752

1 reference

22 September 2017

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