(Q40700908)

22 September 2017

title

Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation (English)

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22 September 2017

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Tove Ostberg

1

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22 September 2017

Göran Bertilsson

2

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22 September 2017

Lena Jendeberg

3

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22 September 2017

Anders Berkenstam

4

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22 September 2017

Jonas Uppenberg

5

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22 September 2017

language of work or name

English

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publication date

1 October 2002

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22 September 2017

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22 September 2017

volume

269

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22 September 2017

issue

19

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22 September 2017

page(s)

4896-4904

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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

22 September 2017

cites work

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Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

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SXR, a novel steroid and xenobiotic-sensing nuclear receptor

21 January 2018

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

21 January 2018

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Cytochrome P450 3A: ontogeny and drug disposition

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Humanized xenobiotic response in mice expressing nuclear receptor SXR.

21 January 2018

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Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene

21 January 2018

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Functionally conserved xenobiotic responsive enhancer in cytochrome P450 3A7.

21 January 2018

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The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

21 January 2018

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The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

21 January 2018

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The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

21 January 2018

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Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

21 January 2018

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Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

21 January 2018

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The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

21 January 2018

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An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

21 January 2018

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The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

21 January 2018

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The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand

21 January 2018

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Improved methods for building protein models in electron density maps and the location of errors in these models

21 January 2018

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The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

21 January 2018

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Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

21 January 2018

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Crystal structure of the ligand binding domain of the human nuclear receptor PPARgamma

21 January 2018

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A structural role for hormone in the thyroid hormone receptor.

21 January 2018

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X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation.

21 January 2018

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A mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers

21 January 2018

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Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein.

21 January 2018

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Ligand-independent activation of the oestrogen receptor by mutation of a conserved tyrosine

21 January 2018

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Recognition of AUG and alternative initiator codons is augmented by G in position +4 but is not generally affected by the nucleotides in positions +5 and +6.

21 January 2018

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10.1046/J.1432-1033.2002.03207.X

21 January 2018

Identifiers

DOI

1 reference

22 September 2017

1 reference