(Q40729905)

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An active form of sphingosine kinase-1 is released in the extracellular medium as component of membrane vesicles shed by two human tumor cell lines.

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20508814%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

An active form of sphingosine kinase-1 is released in the extracellular medium as component of membrane vesicles shed by two human tumor cell lines (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20508814%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Monica Salamone

5

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3 February 2020

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20508814%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

author name string

Salvatrice Rigogliuso

1

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Europe PubMed Central

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3 February 2020

Chiara Donati

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20508814%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Donata Cassarà

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20508814%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Simona Taverna

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20508814%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Maria Letizia Vittorelli

7

1 reference

Europe PubMed Central

PMC publication ID

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3 February 2020

publication date

24 May 2010

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20508814%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Journal of oncology

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20508814%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

2010

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20508814%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

509329

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20508814%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

copyright license

Creative Commons Attribution 3.0 Unported

1 January 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

1 reference

April 2022 Public Data File from Crossref

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

1 reference

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25 September 2017

Intracellular trafficking of endogenous fibroblast growth factor-2.

1 reference

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25 September 2017

Neurons produce FGF2 and VEGF and secrete them at least in part by shedding extracellular vesicles.

1 reference

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25 September 2017

Differential gene expression profile in breast cancer-derived stromal fibroblasts

1 reference

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25 September 2017

Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Bioavailability of VEGF in tumor-shed vesicles depends on vesicle burst induced by acidic pH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

The mechanism of membrane targeting of human sphingosine kinase 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Subcellular localization of human neutral ceramidase expressed in HEK293 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Proinvasive properties of ovarian cancer ascites-derived membrane vesicles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Molecular cloning and functional analysis of zebrafish neutral ceramidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Point-counterpoint of sphingosine 1-phosphate metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

The non-classical export routes: FGF1 and IL-1alpha point the way.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Shedding of membrane vesicles mediates fibroblast growth factor-2 release from cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Molecular evolution of neutral ceramidase: signalling molecule and virulence factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Rapid secretion of interleukin-1beta by microvesicle shedding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Neutral/alkaline and acid ceramidase activities are actively released by murine endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Enrichment and localization of ganglioside G(D3) and caveolin-1 in shed tumor cell membrane vesicles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Sphingosine 1-phosphate signalling in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

The amount and proteolytic content of vesicles shed by human cancer cell lines correlates with their in vitro invasiveness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Molecular cloning and functional characterization of murine sphingosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Arrest and metastasis of blood-borne tumor cells are modified by fusion of plasma membrane vesicles from highly metastatic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Functions of ceramide in coordinating cellular responses to stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

25 September 2017

Shedding of the matrix metalloproteinases MMP-2, MMP-9, and MT1-MMP as membrane vesicle-associated components by endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

17 June 2018

Regulation of ceramide production and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

17 June 2018

Urokinase plasminogen activator and gelatinases are associated with membrane vesicles shed by human HT1080 fibrosarcoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

17 June 2018

Metastatic mouse melanoma cells release collagen-gelatin degrading metalloproteinases as components of shed membrane vesicles.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

17 June 2018

A new cell line (8701-BC) from primary ductal infiltrating carcinoma of human breast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

17 June 2018

TGFbeta protects mesoangioblasts from apoptosis via sphingosine kinase-1 regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

19 August 2018

Astrocytes shed extracellular vesicles that contain fibroblast growth factor-2 and vascular endothelial growth factor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

19 August 2018

Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

19 August 2018

Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi-protein-coupled receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

19 August 2018

Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

19 August 2018

Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

19 August 2018

Neutral ceramidase secreted by endothelial cells is released in part associated with caveolin-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

19 August 2018

O-glycosylation of mucin-like domain retains the neutral ceramidase on the plasma membranes as a type II integral membrane protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

19 August 2018

Serum factors involved in human microvascular endothelial cell morphogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

19 August 2018

Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidney

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875746

19 August 2018

Proceedings: Escape from immune destruction by the host through shedding of surface antigens: is this a characteristic shared by malignant and embryonic cells?

1 reference

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19 August 2018

Human breast carcinoma cells cultured in the presence of serum shed membrane vesicles rich in gelatinolytic activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/20508814

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular membrane vesicles from tumor cells promote angiogenesis via sphingomyelin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20508814

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human Tumor-Derived Exosomes Selectively Impair Lymphocyte Responses to Interleukin-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/20508814

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of plasma membrane shedding from murine melanoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20508814

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20508814

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane vesicles shed by murine melanoma cells selectively inhibit the expression of Ia antigen by macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/20508814

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms and therapeutic reversal of immune suppression in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20508814

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New approaches to the study of sphingolipid enriched membrane domains: the use of electron microscopic autoradiography to reveal metabolically tritium labeled sphingolipids in cell cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/20508814

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and characterization of rat kidney sphingosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20508814

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective localization of matrix metalloproteinase 9, beta1 integrins, and human lymphocyte antigen class I molecules on membrane vesicles shed by 8701-BC breast carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20508814

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane vesicles shed into the extracellular medium by human breast carcinoma cells carry tumor-associated surface antigens

1 reference

https://pubmed.ncbi.nlm.nih.gov/20508814

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1155/2010/509329

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20508814%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20508814%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20508814%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

ResearchGate publication ID

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