(Q40737438)

23 September 2017

Cancer therapy utilizing an adenoviral vector expressing only E1A. (English)

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23 September 2017

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Andrew V Hubberstey

1

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23 September 2017

Marta Pavliv

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2

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23 September 2017

Robin J Parks

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3

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23 September 2017

1 April 2002

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23 September 2017

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23 September 2017

9

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23 September 2017

321-329

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23 September 2017

4

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https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700436

23 September 2017

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cites work

Enhanced expression of p53 in human cells infected with mutant adenoviruses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

E1A directly binds and regulates the P/CAF acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

Association of adenovirus early-region 1A proteins with cellular polypeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

Tumor suppression activity of adenovirus E1a protein: anoikis and the epithelial phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

Antioncogenic effect of adenovirus E1A in human tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

Chemosensitization of HER-2/neu-overexpressing human breast cancer cells to paclitaxel (Taxol) by adenovirus type 5 E1A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

Inhibition of nuclear factor-kappaB activity is involved in E1A-mediated sensitization of radiation-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

Modulation of cellular susceptibility to the cytotoxic/cytostatic action of tumor necrosis factor by adenovirus E1 gene expression is cell type-dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

Induction by E1A oncogene expression of cellular susceptibility to lysis by TNF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for ch

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

High doses of a helper-dependent adenoviral vector yield supraphysiological levels of alpha1-antitrypsin with negligible toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

Characteristics of a human cell line transformed by DNA from human adenovirus type 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

Production and characterization of human 293 cell lines expressing the site-specific recombinase Cre.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

Adenovirus 5 E1A-mediated tumor suppression associated with E1A-mediated apoptosis in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

Does the antitumor adenovirus ONYX-015/dl1520 selectively target cells defective in the p53 pathway?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

E1A is sufficient by itself to induce apoptosis independent of p53 and other adenoviral gene products.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

E1A signaling to p53 involves the p19(ARF) tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

The tumor suppression activity of E1A in HER-2/neu-overexpressing breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

Adenovirus-mediated regulable target gene expression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

Liver-specific alpha 2 interferon gene expression results in protection from induced hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

Improved safety through tamoxifen-regulated induction of cytotoxic genes delivered by Ad vectors for cancer gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

Adenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

A family of transcriptional adaptor proteins targeted by the E1A oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

7 January 2021

E1A sensitizes cells to tumor necrosis factor-induced apoptosis through inhibition of IkappaB kinases and nuclear factor kappaB activities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

7 January 2021

Toxicity associated with repeated administration of first-generation adenovirus vectors does not occur with a helper-dependent vector.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

7 January 2021

Effects of stuffer DNA on transgene expression from helper-dependent adenovirus vectors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

7 January 2021

Is cisplatin-induced cell death always produced by apoptosis?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

7 January 2021

Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700436

7 January 2021

Identifiers

DOI

10.1038/SJ.CGT.7700436

1 reference

Dimensions Publication ID

23 September 2017

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