(Q40751413)

English

Targeting activin receptor-like kinase 1 inhibits angiogenesis and tumorigenesis through a mechanism of action complementary to anti-VEGF therapies

scientific article published on 6 January 2011

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21212415%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Targeting activin receptor-like kinase 1 inhibits angiogenesis and tumorigenesis through a mechanism of action complementary to anti-VEGF therapies (English)

1 reference

Europe PubMed Central

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19 January 2020

12

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19 January 2020

Katherine W. Ferrara

23

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19 January 2020

Francesco Bertolini

25

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19 January 2020

Patrizia Mancuso

5

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Patrizia Mancuso

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19 January 2020

David R Shalinsky

22

object named as

David R Shalinsky

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19 January 2020

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Dana D Hu-Lowe

1

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19 January 2020

Enhong Chen

2

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19 January 2020

Lianglin Zhang

3

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19 January 2020

Katherine D Watson

4

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19 January 2020

Patrick Lappin

6

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19 January 2020

Grant Wickman

7

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19 January 2020

Jeffrey H Chen

8

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19 January 2020

Jianying Wang

9

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19 January 2020

Xin Jiang

10

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19 January 2020

Karin Amundson

11

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19 January 2020

Andreas Erbersdobler

13

1 reference

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19 January 2020

Simon Bergqvist

14

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19 January 2020

Zheng Feng

15

1 reference

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19 January 2020

Terri A Swanson

16

1 reference

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19 January 2020

Brett H Simmons

17

1 reference

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19 January 2020

John Lippincott

18

1 reference

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19 January 2020

Gerald F Casperson

19

1 reference

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19 January 2020

Wendy J Levin

20

1 reference

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19 January 2020

Corrado Gallo Stampino

21

1 reference

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19 January 2020

Walter Fiedler

24

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19 January 2020

language of work or name

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publication date

6 January 2011

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19 January 2020

Cancer Research

1 reference

Europe PubMed Central

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19 January 2020

71

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19 January 2020

4

1 reference

Europe PubMed Central

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19 January 2020

1362-1373

1 reference

Europe PubMed Central

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19 January 2020

ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

ALK1 signaling regulates early postnatal lymphatic vessel development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

Motion corrected cadence CPS ultrasound for quantifying response to vasoactive drugs in a rat kidney model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

TGF-beta signaling in vascular biology and dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

Signaling cross-talk between TGF-beta/BMP and other pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

TGFbeta in Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

Modes of resistance to anti-angiogenic therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

The role of myeloid cells in the promotion of tumour angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

VEGF-targeted cancer therapy strategies: current progress, hurdles and future prospects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

Angiogenesis in health and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

Tumorigenesis and the angiogenic switch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

Vascular morphogenesis: tales of two syndromes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

Antibody discovery: the use of transgenic mice to generate human monoclonal antibodies for therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

The Id proteins and angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

Arteriovenous malformations in mice lacking activin receptor-like kinase-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

Mechanisms of angiogenesis and arteriogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269003

24 September 2017

Angiogenesis-regulating cytokines: activities and interactions

1 reference

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25 September 2017

A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF.

1 reference

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17 June 2018

Suppression of spontaneous melanoma metastasis in scid mice with an antibody to the epidermal growth factor receptor

1 reference

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17 June 2018

Bevacizumab in hereditary hemorrhagic telangiectasia

1 reference

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19 August 2018

Validation of a standardized method for enumerating circulating endothelial cells and progenitors: flow cytometry and molecular and ultrastructural analyses.

1 reference

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19 August 2018

Tumor escape from endogenous, extracellular matrix-associated angiogenesis inhibitors by up-regulation of multiple proangiogenic factors.

1 reference

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19 August 2018

TGFbeta1 induces vasculogenesis and inhibits angiogenic sprouting in an embryonic stem cell differentiation model: respective contribution of ALK1 and ALK5.

1 reference

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19 August 2018

Patients with hereditary hemorrhagic telangiectasia have increased plasma levels of vascular endothelial growth factor and transforming growth factor-beta1 as well as high ALK1 tissue expression.

1 reference

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19 August 2018

Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling

1 reference

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19 August 2018

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19 August 2018

In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship.

1 reference

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19 August 2018

Activin receptor-like kinase 1 inhibits human microvascular endothelial cell migration: Potential roles for JNK and ERK

1 reference

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2 December 2018

1 reference

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2 December 2018

Study of tumor blood perfusion and its variation due to vascular normalization by anti-angiogenic therapy based on 3D angiogenic microvasculature

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dramatic improvement in hereditary hemorrhagic telangiectasia after treatment with the vascular endothelial growth factor (VEGF) antagonist bevacizumab

1 reference

https://pubmed.ncbi.nlm.nih.gov/21212415

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-10-1451

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21212415%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21212415%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21212415%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

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