(Q40766274)

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Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death.

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4 December 2019

Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death (English)

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4 December 2019

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Heiko Düssmann

2

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4 December 2019

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4 December 2019

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Hella Wobser

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4 December 2019

Donat Kögel

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4 December 2019

Haiyan Wang

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4 December 2019

Claus Reimertz

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4 December 2019

Claes B Wollheim

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4 December 2019

Maria M Byrne

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27 November 2001

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4 December 2019

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Journal of Biological Chemistry

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4 December 2019

277

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4 December 2019

6413-6421

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4 December 2019

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4 December 2019

Maturity-onset diabetes of the young

1 reference

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21 January 2018

Maturity-onset diabetes of the young: clinical heterogeneity explained by genetic heterogeneity

1 reference

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21 January 2018

Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12.

1 reference

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21 January 2018

Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20.

1 reference

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21 January 2018

Reduction of glycemic potentiation. Sensitive indicator of beta-cell loss in partially pancreatectomized dogs

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21 January 2018

Beta-cell hypersensitivity for glucose precedes loss of glucose-induced insulin secretion in 90% pancreatectomized rats.

1 reference

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21 January 2018

The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain

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21 January 2018

Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome

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21 January 2018

Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice

1 reference

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21 January 2018

Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse

1 reference

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21 January 2018

Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism

1 reference

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21 January 2018

Mutation P291fsinsC in the transcription factor hepatocyte nuclear factor-1alpha is dominant negative

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Characterization of the MODY3 phenotype. Early-onset diabetes caused by an insulin secretion defect

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Accelerated loss of islet beta cells in sucrose-fed Goto-Kakizaki rats, a genetic model of non-insulin-dependent diabetes mellitus

1 reference

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21 January 2018

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

1 reference

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21 January 2018

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

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21 January 2018

Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

A myosin-like dimerization helix and an extra-large homeodomain are essential elements of the tripartite DNA binding structure of LFB1.

1 reference

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21 January 2018

Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

1-Methyl-4-phenylpyridinium induces autocrine excitotoxicity, protease activation, and neuronal apoptosis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Caspase structure, proteolytic substrates, and function during apoptotic cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Mitochondria as the central control point of apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Interleukin-3 withdrawal induces an early increase in mitochondrial membrane potential unrelated to the Bcl-2 family. Roles of intracellular pH, ADP transport, and F(0)F(1)-ATPase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Caspase-9 can be activated without proteolytic processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Modulation of cell death by Bcl-XL through caspase interaction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

BH3-Only proteins-essential initiators of apoptotic cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin I gene

1 reference

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21 January 2018

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

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21 January 2018

Regulation of cell death protease caspase-9 by phosphorylation

1 reference

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21 January 2018

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

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21 January 2018

CREB is a regulatory target for the protein kinase Akt/PKB

1 reference

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21 January 2018

Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

1 reference

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21 January 2018

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

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21 January 2018

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

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Involvement of 5'-flanking kB-like sites within bcl-x gene in silica-induced bcl-x expression

1 reference

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NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1 reference

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21 January 2018

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

1 reference

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21 January 2018

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

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21 January 2018

Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets

1 reference

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21 January 2018

Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration

1 reference

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21 January 2018

Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats

1 reference

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21 January 2018

Novel MODY3 Mutations in the Hepatocyte Nuclear Factor-1 Gene: Evidence for a Hyperexcitability of Pancreatic -cells to Intravenous Secretagogues in a Glucose-Tolerant Carrier of a P447L Mutation

1 reference

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21 January 2018

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

1 reference

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21 January 2018

Purification and catalytic properties of human caspase family members

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108390200

21 January 2018

Co-localization of the cysteine protease caspase-3 with apoptotic myocytes after in vivo myocardial ischemia and reperfusion in the rat

1 reference

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21 January 2018

Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion

1 reference

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21 January 2018

Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons

1 reference

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21 January 2018

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

1 reference

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21 January 2018

Compensatory Growth of Pancreatic -Cells in Adult Rats After Short-Term Glucose Infusion

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M108390200

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11724785%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11724785%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

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