(Q40803643)

23 September 2017

title

Oncogenic ras represses transforming growth factor-beta /Smad signaling by degrading tumor suppressor Smad4. (English)

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23 September 2017

Saha D

1

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23 September 2017

Datta PK

series ordinal

2

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23 September 2017

Beauchamp RD

series ordinal

3

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23 September 2017

language of work or name

English

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publication date

22 May 2001

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Journal of Biological Chemistry

23 September 2017

published in

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23 September 2017

volume

276

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23 September 2017

issue

31

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23 September 2017

page(s)

29531-29537

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TGF-beta signal transduction

23 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100069200

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Smad3 mutant mice develop metastatic colorectal cancer

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DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

21 January 2018

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MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

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Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

21 January 2018

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A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

21 January 2018

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Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases

21 January 2018

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Blockade of Smad4 in transformed keratinocytes containing a Ras oncogene leads to hyperactivation of the Ras-dependent Erk signalling pathway associated with progression to undifferentiated carcinomas

21 January 2018

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Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA.

21 January 2018

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Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells.

21 January 2018

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Type II TGF(beta) receptor expression in intestinal cell lines and in the intestinal tract

21 January 2018

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Ubiquitin-dependent protein degradation

21 January 2018

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Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway

21 January 2018

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Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

21 January 2018

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Transcriptional control by the TGF-beta/Smad signaling system

21 January 2018

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Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

21 January 2018

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Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

21 January 2018

1 reference

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Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

21 January 2018

1 reference

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Role of transforming growth factor-beta signaling in cancer

21 January 2018

1 reference

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Oncogenic Ras-mediated cell growth arrest and apoptosis are associated with increased ubiquitin-dependent cyclin D1 degradation.

21 January 2018

1 reference

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TGF-beta1 effects on proliferation of rat intestinal epithelial cells are due to inhibition of cyclin D1 expression

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M100069200

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23 September 2017

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