(Q40817321)

24 September 2017

title

Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway (English)

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24 September 2017

D Koul

1

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24 September 2017

Y Yao

2

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24 September 2017

J L Abbruzzese

3

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24 September 2017

W K Yung

4

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24 September 2017

S A Reddy

5

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24 September 2017

language of work or name

English

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publication date

12 January 2001

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Journal of Biological Chemistry

24 September 2017

published in

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24 September 2017

volume

276

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24 September 2017

issue

14

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24 September 2017

page(s)

11402-11408

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The NF-kappa B and I kappa B proteins: new discoveries and insights

24 September 2017

cites work

1 reference

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The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

21 January 2018

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IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

21 January 2018

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IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

21 January 2018

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IKAP is a scaffold protein of the IkappaB kinase complex

21 January 2018

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Identification and characterization of an IkappaB kinase

21 January 2018

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A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

21 January 2018

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IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

21 January 2018

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Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation

21 January 2018

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Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit

21 January 2018

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NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

21 January 2018

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Induction of NF-kappaB by the Akt/PKB kinase

21 January 2018

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NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

21 January 2018

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Requirement of phosphatidylinositol 3-kinase activity for bradykinin stimulation of NF-kappaB activation in cultured human epithelial cells

21 January 2018

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21 January 2018

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Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

21 January 2018

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Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 smallt to promote cell growth and NF-kappa B activation

21 January 2018

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

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The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

21 January 2018

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The lipid phosphatase activity of PTEN is critical for its tumor supressor function

21 January 2018

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 January 2018

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21 January 2018

Phosphoinositide kinases

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AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

21 January 2018

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The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

21 January 2018

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PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

21 January 2018

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Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways

21 January 2018

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NF-kappa B/Rel family members are physically associated phosphoproteins

21 January 2018

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Activation of nuclear factor-kappaB-dependent transcription by tumor necrosis factor-alpha is mediated through phosphorylation of RelA/p65 on serine 529.

21 January 2018

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Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells

21 January 2018

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Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300

21 January 2018

1 reference

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Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

21 January 2018

1 reference

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Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007806200

Limb and skin abnormalities in mice lacking IKKalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007806200

IKK1-deficient mice exhibit abnormal development of skin and skeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007806200

Phosphatidylinositol 3-kinase is recruited to a specific site in the activated IL-1 receptor I

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M007806200

21 January 2018

Identifiers

DOI

10.1074/JBC.M007806200

1 reference

24 September 2017

1 reference