(Q40827018)

24 September 2017

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title

Apoptosis and its role in the myelodysplastic syndromes: implications for disease natural history and treatment (English)

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24 September 2017

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Greenberg PL

1

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24 September 2017

publication date

1 December 1998

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24 September 2017

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24 September 2017

volume

22

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24 September 2017

issue

12

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24 September 2017

page(s)

1123-1136

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Proposals for the classification of the myelodysplastic syndromes

24 September 2017

cites work

1 reference

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7 January 2021

Refined chromosome study helps define prognostic subgroups in most patients with primary myelodysplastic syndrome and acute myelogenous leukaemia

1 reference

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7 January 2021

Ras activation in myelodysplastic syndromes: clinical and molecular study of the chronic phase of the disease

1 reference

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7 January 2021

Apoptosis is a Common Histopathological Finding in Myelodysplasia: the Correlate of Ineffective Haematopoiesis.

1 reference

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7 January 2021

Simultaneous assessment of cell kinetics and programmed cell death in bone marrow biopsies of myelodysplastics reveals extensive apoptosis as the probable basis for ineffective hematopoiesis

1 reference

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7 January 2021

Cell death: the significance of apoptosis

1 reference

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7 January 2021

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1 reference

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7 January 2021

Toward an understanding of the molecular mechanisms of physiological cell death.

1 reference

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7 January 2021

The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1 reference

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7 January 2021

Induction of apoptosis in fibroblasts by c-myc protein

1 reference

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7 January 2021

p53 is required for radiation-induced apoptosis in mouse thymocytes

1 reference

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7 January 2021

Contenders in FasL/TNF death signaling

1 reference

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

1 reference

7 January 2021

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1 reference

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7 January 2021

Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells

1 reference

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7 January 2021

Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Interaction and regulation of subcellular localization of CED-4 by CED-9

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Mitochondria and programmed cell death: back to the future.

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Bcl-x(L) forms an ion channel in synthetic lipid membranes.

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Mitochondrial permeability transition is a central coordinating event of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Regulators of cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Bcl-2 and the ICE family of apoptotic regulators: making a connection.

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Functional dissection of the human Bc12 protein: sequence requirements for inhibition of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Identification of a novel regulatory domain in Bcl-X(L) and Bcl-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism.

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Apoptotic cell death induced by c-myc is inhibited by bcl-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Bcl-2 blocks p53-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Thymocyte apoptosis induced by p53-dependent and independent pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal.

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

p53: puzzle and paradigm

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Life, death, and the pursuit of apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Protease activation during apoptosis: death by a thousand cuts?

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

The role of proteases during apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Human ICE/CED-3 protease nomenclature

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35.

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Mitochondrial control of nuclear apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Daxx, a novel Fas-binding protein that activates JNK and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Lamin proteolysis facilitates nuclear events during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Combined negative and positive selection of mobilized CD34 blood cells

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1 reference

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7 January 2021

Bcl-2, Bax and p53 expression in B-CLL in relation to in vitro survival and clinical progression

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Comparative quantitative expression of bcl-2 by normal and leukaemic myeloid cells

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

The relationship between bcl-2 expression and response to chemotherapy in acute leukaemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

In leukemic hematopoiesis CD34 antigen does not have the same significance as it does normal hematopoiesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Incidence and role of apoptosis in myelodysplastic syndrome: morphological and ultrastructural assessment

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Novel in situ double labeling for simultaneous detection of proliferation and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Morphological changes and apoptosis in bone marrow from patients with myelodysplastic syndromes treated with granulocyte-CSF and erythropoietin

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Is apoptosis a massive process in myelodysplastic syndromes?

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Protooncogene expression in subpopulations of cells from leukemia patients

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Bcl-2 expression by myeloid precursors in myelodysplastic syndromes: relation to disease progression

1 reference

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7 January 2021

p53 mutations in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Occurrence of point mutations in p53 gene is not increased in patients with acute myeloid leukaemia carrying an activating N-ras mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Mutations of the p53 tumour suppressor gene in haematologic neoplasms

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Oxidative DNA damage in CD34+ myelodysplastic cells is associated with intracellular redox changes and elevated plasma tumour necrosis factor-alpha concentration

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Granulopoiesis in acute myeloid leukemia and preleukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Treatment of myelodysplastic syndromes with recombinant human granulocyte colony-stimulating factor. A phase I-II trial

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

A combination of granulocyte colony-stimulating factor and erythropoietin may synergistically improve the anaemia in patients with myelodysplastic syndromes

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Circulating erythropoietin in patients with myelodysplastic syndromes

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

Regulation of bcl-2 proto-oncogene expression during normal human lymphocyte proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0145-2126%2898%2900112-X

7 January 2021

10.1016/S0145-2126(98)00112-X

Identifiers

DOI

1 reference

24 September 2017

1 reference