(Q40839488)

24 September 2017

title

X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway (English)

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24 September 2017

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8

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24 September 2017

J Diao

1

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24 September 2017

A A Khine

2

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24 September 2017

F Sarangi

3

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24 September 2017

E Hsu

4

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24 September 2017

C Iorio

5

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24 September 2017

L A Tibbles

6

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24 September 2017

J R Woodgett

7

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24 September 2017

C D Richardson

9

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24 September 2017

language of work or name

English

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publication date

30 November 2000

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Journal of Biological Chemistry

24 September 2017

published in

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24 September 2017

volume

276

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24 September 2017

issue

11

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24 September 2017

page(s)

8328-8340

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Putative role of hepatitis B virus X protein in hepatocarcinogenesis: effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK/STAT pathways

24 September 2017

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Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome

21 January 2018

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The hepatitis B virus HBx protein inhibits caspase 3 activity.

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Apoptosis regulators from DNA viruses.

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Cytoplasmic retention of the p53 tumor suppressor gene product is observed in the hepatitis B virus X gene-transfected cells

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The hepatitis B virus X gene induces p53-mediated programmed cell death

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E1B 19K inhibits Fas-mediated apoptosis through FADD-dependent sequestration of FLICE.

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The stress-activated protein kinase pathways

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Adenovirus E1B 19,000-molecular-weight protein activates c-Jun N-terminal kinase and c-Jun-mediated transcription

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Erk-independent partial activation of AP-1 sites by the hepatitis B virus HBx protein

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The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes

21 January 2018

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SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis

21 January 2018

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Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade

21 January 2018

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Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls

21 January 2018

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Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras

21 January 2018

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Src kinases involved in hepatitis B virus replication

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Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway

21 January 2018

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Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha

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HBx protein of hepatitis B virus activates Jak1-STAT signaling

21 January 2018

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Hepatitis B virus X protein inhibits transforming growth factor-beta -induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway

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Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage.

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Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

21 January 2018

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X-gene product of hepatitis B virus induces apoptosis in liver cells

21 January 2018

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p53-independent apoptotic effects of the hepatitis B virus HBx protein in vivo and in vitro

21 January 2018

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Induction of apoptosis after switch-on of the hepatitis B virus X gene mediated by the Cre/loxP recombination system

21 January 2018

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Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx.

21 January 2018

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Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway

21 January 2018

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Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

21 January 2018

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Early activation of c-Jun N-terminal kinase and p38 kinase regulate cell survival in response to tumor necrosis factor alpha

21 January 2018

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Suppression of TNF-alpha-induced apoptosis by NF-kappaB

21 January 2018

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

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Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

21 January 2018

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The Activation of the c-Jun N-terminal Kinase and p38 Mitogen-activated Protein Kinase Signaling Pathways Protects HeLa Cells from Apoptosis Following Photodynamic Therapy with Hypericin

21 January 2018

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Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M006026200

Fas induces cytoplasmic apoptotic responses and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of CPP32-like proteases.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M006026200

Mitochondria and apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M006026200

Association of hepatitis B virus X protein with mitochondria causes mitochondrial aggregation at the nuclear periphery, leading to cell death

21 January 2018

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14-3-3 proteins interact with specific MEK kinases

21 January 2018

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Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding

21 January 2018

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Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins

21 January 2018

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The structural basis for 14-3-3:phosphopeptide binding specificity

21 January 2018

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Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis

21 January 2018

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The proapoptotic effect of hepatitis B virus HBx protein correlates with its transactivation activity in stably transfected cell lines

21 January 2018

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Establishment and characterization of cell lines constitutively expressing hepatitis B virus X-protein

21 January 2018

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Induction of apoptosis by the transactivating domains of the hepatitis B virus X gene leads to suppression of oncogenic transformation of primary rat embryo fibroblasts

21 January 2018

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Analysis of the tumorigenicity of the X gene of hepatitis B virus in a nontransformed hepatocyte cell line and the effects of cotransfection with a murine p53 mutant equivalent to human codon 249.

21 January 2018

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Altered pathogenicity in the liver induced by a mouse hepatitis virus type 3 thermosensitive mutant

21 January 2018

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Properties of tumour suppressor p53 in murine hepatocyte lines transformed by hepatitis B virus X protein

21 January 2018

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Differential immediate early gene expression in conditional hepatitis B virus pX-transforming versus nontransforming hepatocyte cell lines

21 January 2018

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HBx gene of hepatitis B virus induces liver cancer in transgenic mice

21 January 2018

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High-level expression of hepatitis B virus HBx gene and hepatocarcinogenesis in transgenic mice

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M006026200

Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M006026200

The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006026200

Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006026200

c-Jun is essential for normal mouse development and hepatogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006026200

Functions of c-Jun in liver and heart development

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M006026200

Interaction of E1B 19K with Bax is required to block Bax-induced loss of mitochondrial membrane potential and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006026200

14-3-3 proteins block apoptosis and differentially regulate MAPK cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006026200

The hepatitis B virus X-associated protein, XAP3, is a protein kinase C-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006026200

A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006026200

HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M006026200

Cell Death in Development

21 January 2018

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/citations/10.1016/S0092-8674(00)80564-4

Identifiers

DOI

10.1074/JBC.M006026200

1 reference

24 September 2017

1 reference