(Q40860169)

24 September 2017

title

Relating multidrug resistance phenotypes to the kinetic properties of their drug-efflux pumps (English)

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24 September 2017

main subject

multiple drug resistance

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1

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24 September 2017

A Riethorst

2

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24 September 2017

A P Jongsma

series ordinal

3

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24 September 2017

language of work or name

English

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publication date

1 September 2000

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24 September 2017

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24 September 2017

volume

267

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24 September 2017

issue

17

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24 September 2017

page(s)

5355-5368

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Biochemical, cellular, and pharmacological aspects of the multidrug transporter

24 September 2017

cites work

1 reference

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Analysis of the tangled relationships between P-glycoprotein-mediated multidrug resistance and the lipid phase of the cell membrane

21 January 2018

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ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells

21 January 2018

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Biochemistry of multidrug resistance mediated by the multidrug transporter

21 January 2018

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Functional analysis of chimeric genes obtained by exchanging homologous domains of the mouse mdr1 and mdr2 genes

21 January 2018

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Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

21 January 2018

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Molecular aspects of organic compound transport across the plasma membrane of hepatocytes.

21 January 2018

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Phosphatidylcholine translocase: a physiological role for the mdr2 gene

21 January 2018

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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

21 January 2018

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P-Glycoprotein, a gatekeeper in the blood-brain barrier

21 January 2018

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The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump

21 January 2018

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Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

21 January 2018

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Altered MRP is associated with multidrug resistance and reduced drug accumulation in human SW-1573 cells

21 January 2018

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The role of the canalicular multispecific organic anion transporter in the disposal of endo- and xenobiotics

21 January 2018

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Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene

21 January 2018

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Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA

21 January 2018

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Topoisomerase II in multiple drug resistance

21 January 2018

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A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps

21 January 2018

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Amino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance

21 January 2018

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Modulatory effects on substrate specificity of independent mutations at the serine939/941 position in predicted transmembrane domain 11 of P-glycoproteins.

21 January 2018

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Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators.

21 January 2018

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Mathematical models for multidrug resistance and its reversal

21 January 2018

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A model for computer simulation of P-glycoprotein and transmembrane delta pH-mediated anthracycline transport in multidrug-resistant tumor cells

21 January 2018

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Transepithelial transport of vinblastine by kidney-derived cell lines. Application of a new kinetic model to estimate in situ Km of the pump

21 January 2018

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The multidrug-resistance-reverser verapamil interferes with cellular P-glycoprotein-mediated pumping of daunorubicin as a non-competing substrate

21 January 2018

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A plasma membrane 'vacuum cleaner' for daunorubicin in non-P-glycoprotein multidrug-resistant SW-1573 human non-small cell lung carcinoma cells. A study using fluorescence resonance energy transfer

21 January 2018

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Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

21 January 2018

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Cyclosporin A and verapamil have different effects on energy metabolism in multidrug-resistant tumour cells

21 January 2018

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Sequence of mdr3 cDNA encoding a human P-glycoprotein

21 January 2018

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Evaluating limited specificity of drug pumps reduced relative resistance in human MDR phenotypes

21 January 2018

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Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies

21 January 2018

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Identification of two distinct regulatory regions adjacent to the human β-interferon gene

21 January 2018

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Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

21 January 2018

1 reference

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Multidrug resistance after retroviral transfer of the human MDR1 gene correlates with P-glycoprotein density in the plasma membrane and is not affected by cytotoxic selection

21 January 2018

1 reference

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Non-P-glycoprotein multidrug resistance in cell lines which are defective in the cellular accumulation of drug

21 January 2018

1 reference

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Structure and expression of the human MDR (P-glycoprotein) gene family

21 January 2018

1 reference

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Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01559.X

Is the multidrug transporter a flippase?

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2000.01559.X

10.1046/J.1432-1327.2000.01559.X

21 January 2018

Identifiers

DOI

1 reference

24 September 2017

1 reference