(Q40898650)

English

Contribution of several metabolites of the vitamin D analog 20-epi-22-oxa-24a,26a,27a-tri-homo-1,25-(OH)(2) vitamin D(3) (KH 1060) to the overall biological activity of KH1060 by a shared mechanism of action

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24 September 2017

Contribution of several metabolites of the vitamin D analog 20-epi-22-oxa-24a,26a,27a-tri-homo-1,25-(OH)(2) vitamin D(3) (KH 1060) to the overall biological activity of KH1060 by a shared mechanism of action (English)

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Europe PubMed Central

PubMed publication ID

24 September 2017

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Hector F. DeLuca

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Deluca HF

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24 September 2017

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ORCID Public Data File 2021

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van den Bemd GC

1

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24 September 2017

Dilworth FJ

2

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24 September 2017

Makin HL

3

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24 September 2017

Prahl JM

4

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24 September 2017

Jones G

6

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24 September 2017

Pols HA

7

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24 September 2017

van Leeuwen JP

8

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24 September 2017

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1 March 2000

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24 September 2017

Biochemical Pharmacology

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24 September 2017

59

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24 September 2017

6

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24 September 2017

621-627

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24 September 2017

The mechanisms of vitamin D toxicity

1 reference

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20-EPI-vitamin D3 analogues: A novel class of potent regulators of cell growth and immune responses

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Immunological properties of vitamin D analogues and metabolites

1 reference

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7 January 2021

Differential effects of 1,25-dihydroxyvitamin D3-analogs on osteoblast-like cells and on in vitro bone resorption

1 reference

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7 January 2021

Conformational change and enhanced stabilization of the vitamin D receptor by the 1,25-dihydroxyvitamin D3 analog KH1060.

1 reference

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7 January 2021

The vitamin D analog, KH1060, is rapidly degraded both in vivo and in vitro via several pathways: principal metabolites generated retain significant biological activity

1 reference

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Osteocalcin during the reproductive cycle in normal and diabetic rats

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An enzyme-linked immunoassay for the 1,25-dihydroxyvitamin D3 receptor protein

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Cloning and expression of full-length cDNA encoding human vitamin D receptor

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Distinct conformational changes induced by 20-epi analogues of 1 alpha,25-dihydroxyvitamin D3 are associated with enhanced activation of the vitamin D receptor

1 reference

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7 January 2021

High-affinity nuclear receptor binding of 20-epi analogues of 1,25-dihydroxyvitamin D3 correlates well with gene activation

1 reference

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7 January 2021

Effect of substituting fluorine for hydrogen at C-26 and C-27 on the side chain of 1,25-dihydroxyvitamin D3

1 reference

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7 January 2021

Increased biological activity of 20-epi-1,25-dihydroxyvitamin D3 is due to reduced catabolism and altered protein binding

1 reference

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Pharmacokinetic studies of vitamin D analogues: relationship to vitamin D binding protein (DBP).

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Metabolism of the vitamin D analog EB1089 by cultured human cells: redirection of hydroxylation site to distal carbons of the side-chain

1 reference

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Current understanding of the molecular actions of vitamin D.

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Transcriptional activity of a fluorinated vitamin D analog on VDR-RXR-mediated gene expression

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Metabolism of the vitamin D analog EB 1089: identification of in vivo and in vitro liver metabolites and their biological activities

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7 January 2021

Synthetic studies of vitamin D analogs. XXII. Synthesis and antiproliferation activity of putative metabolites of 1 alpha, 25-dihydroxy-22-oxavitamin D3

1 reference

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7 January 2021

Calcipotriol (MC 903): pharmacokinetics in rats and biological activities of metabolites. A comparative study with 1,25(OH)2D3.

1 reference

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7 January 2021

Tamoxifen metabolites in patients on long-term adjuvant therapy for breast cancer

1 reference

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7 January 2021

The importance of tamoxifen metabolism in tamoxifen-stimulated breast tumor growth

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7 January 2021

Evaluation of the major metabolites of raloxifene as modulators of tissue selectivity

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7 January 2021

Identifiers

10.1016/S0006-2952(99)00371-8

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

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