(Q40902474)

24 September 2017

1 reference

title

Genetic polymorphisms in human drug-metabolizing enzymes: potential uses of reverse genetics to identify genes of toxicological relevance (English)

1 reference

24 September 2017

Puga A

1

1 reference

24 September 2017

Nebert DW

series ordinal

2

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24 September 2017

McKinnon RA

series ordinal

3

1 reference

24 September 2017

Menon AG

series ordinal

4

1 reference

24 September 2017

language of work or name

English

0 references

publication date

1 March 1997

1 reference

Critical Reviews in Toxicology

24 September 2017

published in

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24 September 2017

volume

27

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24 September 2017

issue

2

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24 September 2017

page(s)

199-222

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Pharmacogenetics: its biologic roots and the medical challenge

24 September 2017

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Life of a pharmacologist or the rich life of a poor metabolizer.

21 January 2018

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P450 genes: structure, evolution, and regulation

21 January 2018

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The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

21 January 2018

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The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature

21 January 2018

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A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities

21 January 2018

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The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence

21 January 2018

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Role of genetics and drug metabolism in human cancer risk

21 January 2018

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The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects

21 January 2018

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Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin

21 January 2018

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Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor

21 January 2018

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cDNA cloning and structure of mouse putative Ah receptor

21 January 2018

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Research on the aryl hydrocarbon (dioxin) receptor is primed to take off.

21 January 2018

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The Ah receptor and the mechanism of dioxin toxicity

21 January 2018

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Role of the Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer, and signal transduction.

21 January 2018

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Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action

21 January 2018

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Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma.

21 January 2018

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Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo- p-dioxin

21 January 2018

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Cancer mortality among workers in chemical plant contaminated with dioxin

21 January 2018

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Long-term effects of chemical disasters. Lessons and results from Seveso

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408449709021619

Aryl hydrocarbon hydroxylase and 16?-hydroxylase in cultured human lymphocytes

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408449709021619

Aryl-hydrocarbon hydroxylase activity in lymphocytes from lung cancer patients and normal controls

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408449709021619

Aryl-hydrocarbon-hydroxylase inducibility in patients with cancer

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408449709021619

Aryl hydrocarbon hydroxylase and bronchogenic carcinomas associated with smoking

21 January 2018

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Induction of aryl hydrocarbon hydroxylase activity and pulmonary carcinoma

21 January 2018

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Aryl hydrocarbon hydroxylase activity in pulmonary alveolar macrophages and lymphocytes from lung cancer and noncancer patients: A correlation with family histories of cancer

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408449709021619

Letter: Aryl hydrocarbon hydroxylase inducibility and laryngeal carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Polycyclic aromatic hydrocarbon-DNA adducts and the CYP1A1 restriction fragment length polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Questionable relation of aryl hydrocarbon hydroxylase to lung-cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Aryl hydrocarbon hydroxylase inducibility is not altered in bladder cancer patients or their progeny

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P45 0IA1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

PCR detection of an A/G polymorphism within exon 7 of the CYP1A1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

High susceptibility to lung cancer analyzed in terms of combined genotypes of P450IA1 and Mu-class glutathione S-transferase genes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

A novel CYP1A1 gene polymorphism in African-Americans.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

A race-specific genetic polymorphism in the CYP1A1 gene is not associated with lung cancer in African Americans.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Polymorphic hydroxylation of Debrisoquine in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Molecular genetics of the debrisoquin-sparteine polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Nomenclature for human glutathione transferases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Pharmacogenetic phenotyping and genotyping. Present status and future potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Pharmacogenetics: the slow, the rapid, and the ultrarapid

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Ecogenetics of Parkinson's disease: 4-hydroxylation of debrisoquine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Debrisoquine hydroxylation in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Poor hydroxylator phenotypes of debrisoquine and S-mephenytoin are not over-represented in a group of patients with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Are poor metabolisers of sparteine/debrisoquine less pain tolerant than extensive metabolisers?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Lung cancer and the debrisoquine metabolic phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Polymorphism of cytochrome P-450 in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Genotyping for polymorphisms in xenobiotic metabolism as a predictor of disease susceptibility.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Two common RFLPs of the human CYP2E gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Genetic Polymorphisms in the 5′-Flanking Region Change Transcriptional Regulation of the Human Cytochrome P450IIE1 Gene1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Association between Restriction Fragment Length Polymorphism of the Human Cytochrome P450IIE1 Gene and Susceptibility to Lung Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Genetic polymorphism of cytochrome P4502E1 in a Swedish population. Relationship to incidence of lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Characterization of ethanol-inducible human liver N-nitrosodimethylamine demethylase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

The fish odour syndrome: biochemical, familial, and clinical aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Glutathione S-transferase and epoxide hydrolase activity in human leukocytes in relation to risk of lung cancer and other smoking-related cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

The glucuronidation of hydroxylated metabolites of benzo[a]pyrene and 2-acetylaminofluorene by cDNA-expressed human UDP-glucuronosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Structure and restriction fragment length polymorphism of genes for human liver arylamine N-acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Nomenclature for N-acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Preliminary phenotypic map of chromosome 4p16 based on 4p deletions.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

N-Acetyltransferase phenotype of patients with bladder cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

N-acetylation phenotype and genotype and risk of bladder cancer in benzidine-exposed workers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Diverse point mutations in the human gene for polymorphic N-acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Glutathione S-transferases: gene structure and regulation of expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Human glutathione S-transferases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Use of site-directed mutagenesis of allele-specific PCR primers to identify the GSTM1 A, GSTM1 B, GSTM1 A,B and GSTM1 null polymorphisms at the glutathione S-transferase, GSTM1 locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Expression and polymorphism of glutathione S-transferase in human lungs: risk factors in smoking-related lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

The glutathione S-transferases: polymerase chain reaction studies on the frequency of the GSTM1 0 genotype in patients with pituitary adenomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Combined effect of CYP1A1 inducibility and GSTM1 polymorphism on histological type of lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Polymorphism of glutathione S-transferase M1 and lung cancer risk among African-Americans and Caucasians in Los Angeles County, California.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Glutathione S-transferase GSTM1 phenotypes and protection against cutaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Phenotype of glutathione S-transferase Mu (GSTM1) and susceptibility to malignant melanoma. MMM group. Multidisciplinary Malignant Melanoma Group

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Ethnic distribution of the glutathione transferase Mu 1-1 (GSTM1) null genotype in 1473 individuals and application to bladder cancer susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Lung cancer risk of GSTM1 null genotype is dependent on the extent of tobacco smoke exposure.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Theta class glutathione S-transferase GSTT1 genotypes and susceptibility to cervical neoplasia: interactions with GSTM1, CYP2D6 and smoking.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Roles of different forms of cytochrome P450 in the activation of the promutagen 6-aminochrysene to genotoxic metabolites in human liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Polymorphisms for aromatic amine metabolism in humans: relevance for human carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Comparative metabolism of benzo[a]pyrene and drugs in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

The CYP2 A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Localization of CYP2F1 by multipoint linkage analysis and pulsed-field gel electrophoresis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Biochemistry and molecular biology of the human CYP2C subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Nifedipine: variability in its kinetics and metabolism in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

CYP3A gene expression in human gut epithelium

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408449709021619

Human and rabbit paraoxonases: purification, cloning, sequencing, mapping and role of polymorphism in organophosphate detoxification

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Cystic fibrosis locus defined by a genetically linked polymorphic DNA marker.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Serum paraoxonase polymorphism in three populations of southeast Asia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Genetic dissection of complex traits

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Sib pair linkage analysis of renin gene haplotypes in human essential hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Molecular basis of human hypertension: role of angiotensinogen

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

A genome-wide search for human type 1 diabetes susceptibility genes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Noninvasive tests of CYP3A enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Metabolic oxidation phenotypes as markers for susceptibility to lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

Genetically based N-acetyltransferase metabolic polymorphism and low-level environmental exposure to carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449709021619

10.3109/10408449709021619

21 January 2018

Identifiers

DOI

1 reference

24 September 2017

1 reference