(Q38317576)

2 September 2017

1 reference

title

The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects (English)

1 reference

2 September 2017

D W Nebert

1

1 reference

PubMed ID

2558673

2 September 2017

language of work or name

English

0 references

publication date

1 January 1989

1 reference

Critical Reviews in Toxicology

2 September 2017

1 reference

2 September 2017

20

1 reference

2 September 2017

3

1 reference

2 September 2017

153-174

1 reference

The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states.

2 September 2017

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

P450 genes: structure, evolution, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Regulation of the mammalian cytochrome P1-450 (CYP1A1) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Molecular biology of steroid hormone synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

TheAhLocus: Genetic Regulation of the Metabolism of Carcinogens, Drugs, and Other Environmental Chemicals by Cytochrome P-450-Mediated Monooxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Differential induction of murine Ah locus-associated monooxygenase activities in rabbit liver and kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Evidence in rat and mouse liver for temporal control of two forms of cytochrome P-450 inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Chromosomal organization of the cytochrome P450-2C gene family in the mouse: a locus associated with constitutive aryl hydrocarbon hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Tissue-specific expression of the mouse dioxin-inducible P(1)450 and P(3)450 genes: differential transcriptional activation and mRNA stability in liver and extrahepatic tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Physicochemical characterization of the nuclear form of Ah receptor from mouse hepatoma cells exposed in culture to 2,3,7,8-tetrachlorodibenzo-p-dioxin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Specific protein-DNA interactions at a xenobiotic-responsive element: copurification of dioxin receptor and DNA-binding activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Regulation of mouse CYP1A1 gene expression by dioxin: requirement of two cis-acting elements during induction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Multiple forms of inducible drug-metabolizing enzymes: A reasonable mechanism by which any organism can cope with adversity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Dominant and recessive aryl hydrocarbon hydroxylase-deficient mutants of mouse hepatoma line, Hepa-1, and assignment of recessive mutants to three complementation groups

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Dibenz[a,h]anthracene-induced subcutaneous tumors in mice. Strain sensitivity and the role of carcinogen metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Fetal mouse susceptibility to transplacental lung and liver carcinogenesis by 3-methylcholanthrene: positive correlation with responsiveness to inducers of aromatic hydrocarbon metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

An Improved Bacterial Test System for the Detection and Classification of Mutagens and Carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Benzo(a)pyrene metabolites: efficient and rapid separation by high-pressure liquid chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Benzo[a]pyrene metabolism in mouse liver. Association of both 7,8-epoxidation and covalent binding of a metabolite of the 7,8-diol with the Ah locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Birth defects and aplastic anemia: differences in polycyclic hydrocarbon toxicity associated with the Ah locus

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

The genetic basis of susceptibility to leukemia induction in mice by 3-methylcholanthrene applied percutaneously

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Presystemic Drug Elimination

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Rank Order of Sarcoma Susceptibility Among Mouse Strains Reverses with Low Concentrations of Carcinogen

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Genetic differences in susceptibility to chemically induced myelotoxicity and leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Cytochrome P-450 isozyme selectivity in the oxidation of acetaminophen.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Genetic expression of aflatoxin metabolism. Effects of 3-methylcholanthrene and beta-naphthoflavone on hepatic microsomal metabolism and mutagenic activation of aflatoxins.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Mutagenic activation of aflatoxin B1 by several forms of purified cytochrome P-450.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Ah Locus: Genetic Differences in Susceptibility to Cataracts Induced by Acetaminophen

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

In vivo murine studies on the biochemical mechanism of naphthalene cataractogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Smoking and industrial pollution, and their effects on menopause and ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Incomplete correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin hepatotoxicity with Ah phenotype in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Synergism of iron and hexachlorobenzene inhibits hepatic uroporphyrinogen decarboxylase in inbred mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

The role of the Ah locus in hexachlorobenzene-induced porphyria. Studies in congenic C57BL/6J mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Oxidation of uroporphyrinogen by methylcholanthrene-induced cytochrome P-450. Essential role of cytochrome P-450d

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Inhibition of 2-aminofluorene mutagenesis in bacteria by inducers of cytochrome P-450d.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Induction of immunotoxicity by polycyclic hydrocarbons: role of the Ah locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Sensitivity to suppression of cytotoxic T cell generation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is dependent on the Ah genotype of the murine host.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Heart as a target organ in 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity: decreased beta-adrenergic responsiveness and evidence of increased intracellular calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Evidence for a Monoclonal Origin of Human Atherosclerotic Plaques

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Increased total and high density lipoprotein cholesterol with apoprotein changes resembling streptozotocin diabetes in tetrachlorodibenzodioxin (TCDD) treated rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Genetically mediated induction of drug-metabolizing enzymes associated with congenital defects in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

The murine Ah locus: in utero toxicity and teratogenesis associated with genetic differences in benzo[a]pyrene metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Cultured mouse embryos metabolize benzo[a]pyrene during early gestation: genetic differences detectable by sister chromatid exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Cytochrome P-450 metabolic activity in embryonic and extraembryonic tissue lineages of mouse embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Developmental onset of mixed-function oxidase activity in preimplantation mouse embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Developmental and tissue-specific differential regulation of the mouse dioxin-inducible P1-450 and P3-450 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Glutathione S-transferase Ya subunit gene: identification of regulatory elements required for basal level and inducible expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Regulatory elements controlling the basal and drug-inducible expression of glutathione S-transferase Ya subunit gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Cloning and complete nucleotide sequence of a full-length cDNA encoding a catalytically functional tumor-associated aldehyde dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Phospholipase activity in skin after application of phorbol esters and 3-methylcholanthrene.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) enhances antibody production and protein kinase activity in murine B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

2,3,7,8-Tetrachlorodibenzo-p-dioxin causes elevation of the levels of the protein tyrosine kinase pp60c-src

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

2,3,7,8-Tetrachlorodibenzo-p-dioxin causes increases in expression of c-erb-A and levels of protein-tyrosine kinases in selected tissues of responsive mouse strains

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Hepatic Ah-receptor levels and the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on hepatic microsomal monooxygenase activities in a TCDD-susceptible and -resistant rat strain

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) as a potent and persistent thyroxine agonist: a mechanistic model for toxicity based on molecular reactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Tumour promotion by TCDD in skin of HRS/J hairless mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

Benoxaprofen suppression of polychlorinated biphenyl toxicity without alteration of mixed function oxidase function

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448909017908

10.3109/10408448909017908

21 January 2018

Identifiers

DOI

1 reference

2 September 2017

1 reference

PubMed ID

2558673