(Q40916452)

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Preliminary evaluation of the toxicity and efficacy of novel 2,4-diamino-5-benzylpyrimidine-sulphone derivatives using rat and human tissues in vitro

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Europe PubMed Central

PubMed publication ID

24 September 2017

Preliminary evaluation of the toxicity and efficacy of novel 2,4-diamino-5-benzylpyrimidine-sulphone derivatives using rat and human tissues in vitro (English)

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

author name string

Coleman MD

1

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

Thorpe S

2

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

Lewis S

3

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

Buck NS

4

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

Perris AD

5

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

Seydel JK

6

1 reference

Europe PubMed Central

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24 September 2017

publication date

1 December 1996

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Europe PubMed Central

PubMed publication ID

24 September 2017

Environmental Toxicology and Pharmacology

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Europe PubMed Central

PubMed publication ID

24 September 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

389-395

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Europe PubMed Central

PubMed publication ID

24 September 2017

Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9

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Dapsone Suppresses Integrin-Mediated Neutrophil Adherence Function

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Reduction of dapsone hydroxylamine to dapsone during methaemoglobin formation in human erythrocytes in vitro--II. Movement of dapsone across a semipermeable membrane into erythrocytes and plasma

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Use of a metabolic inhibitor to reduce dapsone-dependent haematological toxicity

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Bioactivation of dapsone to a cytotoxic metabolite by human hepatic microsomal enzymes

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The use of cimetidine as a selective inhibitor of dapsone N-hydroxylation in man.

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Sex-dependent sensitivity to dapsone-induced methaemoglobinaemia in the rat

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An Investigation into the Haematological Toxicity of Structural Analogues of Dapsone In-vivo and In-vitro

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Dapsone: modes of action, toxicity and possible strategies for increasing patient tolerance

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Studies on the toxicity of analogues of dapsone in-vitro using rat, human and heterologously expressed metabolizing systems

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An international randomized study with long-term follow-up of single versus combination chemotherapy of multibacillary leprosy

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Chemotherapy of lepromatous leprosy: Recent developments and prospects for the future

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N-Hydroxylation of dapsone by multiple enzymes of cytochrome P450: implications for inhibition of haemotoxicity

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Improved rapid photometric assay for quantitative measurement of PMN migration

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Dapsone, trimethoprim, and sulfamethoxazole plasma levels during treatment of Pneumocystis pneumonia in patients with the acquired immunodeficiency syndrome (AIDS). Evidence of drug interactions

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The hydroxylamine of sulfamethoxazole and adverse reactions in patients with acquired immunodeficiency syndrome

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Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo*

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The metabolism of 17 alpha-ethinyloestradiol by human liver microsomes: formation of catechol and chemically reactive metabolites

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5-BENZYL-2,4-DIAMINOPYRIMIDINES AS ANTIBACTERIAL AGENTS. I. SYNTHESIS AND ANTIBACTERIAL ACTIVITY IN VITRO.

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Experimental drugs and combination therapy.

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An investigation of the role of metabolism in dapsone-induced methaemoglobinaemia using a two compartment in vitro test system

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Randomized trial of dapsone and aerosolized pentamidine for the prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis

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Pyrimethamin-resistantPlasmodium falciparum lack cross-resistance to methotrexate and 2,4-diamino-5-(substituted benzyl) pyrimidines

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New antifolate 4,4'-diaminodiphenyl sulfone substituted 2,4-diamino-5-benzylpyrimidines. Proof of their dual mode of action and autosynergism

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Cotrimoxazole as an inhibitor of oxidative drug metabolism: effects of trimethoprim and sulphamethoxazole separately and combined on tolbutamide disposition

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Identifiers

10.1016/S1382-6689(96)00076-2

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

release_ung243ux3fggzcsiejeamkoplu

1 reference

https://api.fatcat.wiki/v0/release/ung243ux3fggzcsiejeamkoplu

24 November 2022

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mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

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