(Q40949744)

25 September 2017

title

Changes during subclone development and ageing of human antibody-producing recombinant CHO cells (English)

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25 September 2017

2

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25 September 2017

R Kunert

3

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author name string

K Strutzenberger

series ordinal

1

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25 September 2017

W Steinfellner

series ordinal

4

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25 September 2017

H Katinger

series ordinal

5

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25 September 2017

publication date

1 April 1999

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25 September 2017

published in

Journal of Biotechnology

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25 September 2017

volume

69

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25 September 2017

issue

2-3

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25 September 2017

page(s)

215-226

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High-level expression of a recombinant antibody from myeloma cells using a glutamine synthetase gene as an amplifiable selectable marker

25 September 2017

cites work

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7 January 2021

Use of a structured kinetic model of antibody synthesis and secretion for optimization of antibody production systems: I. Steady-state analysis

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Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas

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7 January 2021

Analysis of changes during subclone development and ageing of human antibody-producing heterohybridoma cells by northern blot and flow cytometry.

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Relationship between loss of heavy chains and the appearance of nonproducing hybridomas

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7 January 2021

High level expression on a chimeric anti-ganglioside GD2 antibody: genomic kappa sequences improve expression in COS and CHO cells

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7 January 2021

The loss of antibody productivity in continuous culture of hybridoma cells

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7 January 2021

Expression of FSH in CHO cells, I. Comparison of promoter types and effects of their respective inducers

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7 January 2021

Effect of amplification of dhfr and lac Z genes on growth and beta-galactosidase expression in suspension cultures of recombinant CHO cells

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7 January 2021

Methods for increasing monoclonal antibody production in suspension and entrapped cell cultures: biochemical and flow cytometric analysis as a function of medium serum content

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Amplification and expression of sequences cotransfected with a modular dihydrofolate reductase complementary DNA gene

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Coamplification and coexpression of human tissue-type plasminogen activator and murine dihydrofolate reductase sequences in Chinese hamster ovary cells

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Stability of producer hybridoma cell lines after cell sorting: a case study

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Cell Culture conditions determine the enhancement of specific monoclonal antibody productivity of calcium alginate-entrapped S3H5/gamma2bA2 hybridoma cells

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Immobilization can improve the stability of hybridoma antibody productivity in serum-free media

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Modified monoclonal antibody production kinetics kappa/gamma mRNA levels, and metabolic activities in a murine hybridoma selected by continuous Culture

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7 January 2021

The effect of the rat immunoglobulin heavy-chain 3' enhancer is position dependent

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7 January 2021

High level expression of the humanized monoclonal antibody Campath-1H in Chinese hamster ovary cells

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Effects of methotrexate on transfected DNA stability in mammalian cells

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7 January 2021

Cell cycle kinetics and monoclonal antibody productivity of hybridoma cells during perfusion culture

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7 January 2021

Effect of cloned gene dosage on cell growth and hepatitis B surface antigen synthesis and secretion in recombinant CHO cells

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7 January 2021

Overexpression of recombinant human antithrombin III in Chinese hamster ovary cells results in malformation and decreased secretion of recombinant protein

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7 January 2021

Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity

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7 January 2021

Integration, amplification and stability of plasmid sequences in CHO cell cultures

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7 January 2021

Plasmid integration, amplification and cytogenetics in CHO cells: questions and comments

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7 January 2021

10.1016/S0168-1656(99)00044-9

Identifiers

DOI

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25 September 2017

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