(Q40949802)

English

Human B cells accumulate immunoglobulin V gene somatic mutations in a cell contact-dependent manner in cultures supported by activated T cells but not in cultures supported by CD40 ligand

scientific article published on June 1999

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

Human B cells accumulate immunoglobulin V gene somatic mutations in a cell contact-dependent manner in cultures supported by activated T cells but not in cultures supported by CD40 ligand (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

author name string

S C Huang

1

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

A M Glas

2

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

G V Pinchuk

3

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

E H Van Montfort

4

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

S P Rao

5

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

R Jiang

6

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

E C Milner

7

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

publication date

1 June 1999

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

Clinical and Experimental Immunology

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

116

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

441-448

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

Motif-specific probes identify individual genes and detect somatic mutations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

VH usage and somatic hypermutation in peripheral blood B cells of patients with rheumatoid arthritis (RA).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

In vitro triggering of somatic mutation in human naive B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Induction of germinal center B cell markers in vitro by activated CD4+ T lymphocytes: the role of CD40 ligand, soluble factors, and B cell antigen receptor cross-linking.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

VH repertoire in human B lymphocytes stimulated by CD40 ligand and IL-4: evidence for positive and negative selection mechanisms coupled to CD40 activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Analysis of the VH3 repertoire among genetically disparate individuals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Induction of somatic mutation in a human B cell line in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Analysis of rearranged immunoglobulin heavy chain variable region genes obtained from a bone marrow transplant (BMT) recipient

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Sequential triggering of apoptosis, somatic mutation and isotype switch during germinal center development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Non-stochastic utilization of Ig V region genes in unselected human peripheral B cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Differential V region mutation of two transfected Ig genes and their interaction in cultured B cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

CD28 is required for germinal center formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Immunoglobulin heavy chain variable region gene usage in bone marrow transplant recipients: lack of somatic mutation indicates a maturational arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Chromosomal organization of the human VH4 gene family. Location of individual gene segments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Comparison of somatic mutation frequency among immunoglobulin genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Analysis of somatic mutation in five B cell subsets of human tonsil

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Representation of rearranged VH gene segments in the human adult antibody repertoire

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Structural characteristics of CD40 ligand that determine biological function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Polymorphism and utilization of human VH Genes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Anomalous diversification of the antibody repertoire following bone marrow transplantation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Somatic mutations of immunoglobulin variable genes are restricted to the rearranged V gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Base composition-independent hybridization in tetramethylammonium chloride: a method for oligonucleotide screening of highly complex gene libraries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Patterns of somatic mutations in immunoglobulin variable genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Immunoglobulin VH gene expression in human B cell lines and tumors: biased VH gene expression in chronic lymphocytic leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Heterogeneity in the human Ig VH locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Lack of somatic mutation in a kappa light chain transgene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Prevalence and polymorphism of human VH3 genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Maturation of the immune response in germinal centers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Long-Term Human B Cell Lines Dependent on Interleukin-4 and antibody to CD40

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Polymorphism of the human Ig VH4 gene family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Mapping of human H chain V region genes (VH4) using deletional analysis and pulsed field gel electrophoresis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Chromosomal organization of the heavy chain variable region gene segments comprising the human fetal antibody repertoire

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

Molecular and biological characterization of a murine ligand for CD40

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1905311

14 September 2018

T cell-dependent activation of B cell proliferation and differentiation by immobilized monoclonal antibodies to CD3

1 reference

https://pubmed.ncbi.nlm.nih.gov/10361232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequency of human B cells that differentiate in response to anti-CD3-activated T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10361232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-CD3-stimulated T cells induce the production of multiple Ig H chain isotypes by individual human peripheral B lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10361232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human B cell proliferation and Ig secretion induced by recombinant CD40 ligand are modulated by soluble cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/10361232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1 reference

https://pubmed.ncbi.nlm.nih.gov/10361232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process

1 reference

https://pubmed.ncbi.nlm.nih.gov/10361232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-CD40 plus interleukin-4-activated human naive B cell lines express unmutated immunoglobulin genes with intraclonal heavy chain isotype variability

1 reference

https://pubmed.ncbi.nlm.nih.gov/10361232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic mutation of immunoglobulin V genes in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/10361232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal human IgD+IgM- germinal center B cells can express up to 80 mutations in the variable region of their IgD transcripts

1 reference

https://pubmed.ncbi.nlm.nih.gov/10361232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1046/J.1365-2249.1999.00919.X

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

PMC publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

ResearchGate publication ID

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