(Q40958970)

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Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation

scientific article published on 9 October 2015

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scholarly article

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Europe PubMed Central

PMC publication ID

25 September 2017

Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation (English)

1 reference

Europe PubMed Central

PMC publication ID

25 September 2017

phosphorylation

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based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Rebecca J Brownlie

2

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object named as

Rose Zamoyska

4

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1

object named as

Robert J Salmond

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Europe PubMed Central

PMC publication ID

25 September 2017

author name string

Oded Meyuhas

3

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Europe PubMed Central

PMC publication ID

25 September 2017

language of work or name

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publication date

9 October 2015

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Europe PubMed Central

PMC publication ID

25 September 2017

Journal of Immunology

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Europe PubMed Central

PMC publication ID

25 September 2017

195

1 reference

Europe PubMed Central

PMC publication ID

25 September 2017

10

1 reference

Europe PubMed Central

PMC publication ID

25 September 2017

4615-4622

1 reference

Europe PubMed Central

PMC publication ID

25 September 2017

copyright license

Creative Commons Attribution 3.0 Unported

5 November 2022

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April 2023 Public Data File from Crossref

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0 references

Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21-mediated tumor suppressor Pdcd4 repression

1 reference

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Targeting T cell metabolism for therapy

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Regulation of T cells by mTOR: the known knowns and the known unknowns

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The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation

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Cutting edge: generation of effector cells that localize to mucosal tissues and form resident memory CD8 T cells is controlled by mTOR.

1 reference

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T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming

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Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system

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mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function

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Regulation of immune responses by mTOR.

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The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

1 reference

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mTOR regulates memory CD8 T-cell differentiation

1 reference

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An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

1 reference

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Physiological roles of ribosomal protein S6: one of its kind

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The selectivity of protein kinase inhibitors: a further update

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S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth

1 reference

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Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation

1 reference

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Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.

1 reference

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Ribosomal protein S6 phosphorylation: from protein synthesis to cell size.

1 reference

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Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response.

1 reference

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mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

1 reference

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Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis

1 reference

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Migratory properties of naive, effector, and memory CD8(+) T cells

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Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes

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p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes

1 reference

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T cell receptor antagonist peptides induce positive selection

1 reference

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Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

1 reference

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1 reference

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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1 reference

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1 reference

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PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORγ.

1 reference

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How does the mammalian target of rapamycin (mTOR) influence CD8 T cell differentiation?

1 reference

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The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin

1 reference

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MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells

1 reference

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Generation of CD8 T cell memory is regulated by IL-12.

1 reference

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21 January 2018

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10.4049/JIMMUNOL.1501473

1 reference

Europe PubMed Central

PMC publication ID

25 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

25 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

25 September 2017

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