(Q40959038)

25 September 2017

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title

Clinical pharmacokinetic and pharmacodynamic considerations in patients with liver disease. An update (English)

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25 September 2017

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D J Morgan

1

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PubMed ID

8582120

25 September 2017

A J McLean

series ordinal

2

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25 September 2017

1 November 1995

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Clinical Pharmacokinetics

25 September 2017

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25 September 2017

29

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25 September 2017

5

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25 September 2017

370-391

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https://scigraph.springernature.com/pub.10.2165/00003088-199529050-00005

25 September 2017

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Pharmacokinetics of azithromycin in patients with impaired hepatic function

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12 December 2020

Therapeutic implications of impaired hepatic oxygen diffusion in chronic liver disease

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12 December 2020

Furosemide absorption in patients with cirrhosis.

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12 December 2020

Effect of liver function on the metabolism of prednisone and prednisolone in humans

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12 December 2020

The metabolic chiral inversion and dispositional enantioselectivity of the 2-arylpropionic acids and their biological consequences

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12 December 2020

Pharmacokinetics of zidovudine in patients with liver cirrhosis

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12 December 2020

Pharmacokinetics of Temafloxacin in Patients with Liver Impairment†

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12 December 2020

Diseases and Drug Protein Binding

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12 December 2020

Quantitation of intrinsic drug-metabolizing capacity in human liver biopsy specimens: Support for the intact-hepatocyte theory

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12 December 2020

Effect of hepatic cirrhosis on the pharmacodynamics and pharmacokinetics of mivacurium in humans

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12 December 2020

Antipyrine elimination and hepatic microsomal enzyme activity in patients with liver disease

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12 December 2020

Pharmacokinetics of diacerein in patients with liver cirrhosis

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12 December 2020

Pharmacokinetics of metoclopramide in patients with liver cirrhosis.

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12 December 2020

The influence of verapamil and nifedipine on hepatic indocyanine green clearance in patients with HBsAg-positive cirrhosis and ascites

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12 December 2020

Disposition of a flow-limited drug (lidocaine) and a metabolic capacity-limited drug (theophylline) in liver cirrhosis.

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12 December 2020

Hepatic enzyme activity is the major factor determining elimination rate of high-clearance drugs in cirrhosis

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12 December 2020

Pharmacokinetics of ornidazole in patients with acute viral hepatitis, alcoholic cirrhosis, and extrahepatic cholestasis

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12 December 2020

Chronic verapamil administration lowers portal pressure and improves hepatic function in rats with liver cirrhosis

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12 December 2020

Gastrointestinal transit of solid-liquid meal in chronic alcoholics

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12 December 2020

Quantifying hepatic function in the presence of liver disease with phenazone (antipyrine) and its metabolites

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12 December 2020

Hepatic artery and portal vein vascularization of normal and cirrhotic rat liver

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12 December 2020

Verapamil favorably influences hepatic microvascular exchange and function in rats with cirrhosis of the liver

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12 December 2020

Pharmacokinetics of adriamycin, adriamycinol, and antipyrine in patients with moderate tumor involvement of the liver

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12 December 2020

Pharmacokinetics of ceftazidime in patients with liver cirrhosis and ascites

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12 December 2020

The effects of impaired liver function on the elimination of antineoplastic agents

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12 December 2020

Metabolism of antipyrine in vivo in two rat models of liver cirrhosis. Its relationship to intrinsic clearance in vitro and microsomal membrane lipid composition

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12 December 2020

Theophylline metabolism in patients with hepatosplenic mansoniasis and cirrhosis

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12 December 2020

Cefpiramide kinetics and plasma protein binding in cholestasis

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12 December 2020

Pharmacokinetics of famotidine in patients with cirrhosis and ascites

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12 December 2020

Hepatic drug clearance in chronic liver disease: can we expect to find a universal, quantitative marker of hepatic function?

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12 December 2020

Oxygen supplementation restores theophylline clearance to normal in cirrhotic rats

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12 December 2020

Theophylline pharmacokinetics and liver function indexes in chronic liver disease

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12 December 2020

Pharmacokinetics of famotidine in normal subjects and in patients with chronic liver disease

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12 December 2020

Pharmacokinetics and haemodynamic effects of a single oral dose of the novel ACE inhibitor spirapril in patients with chronic liver disease

1 reference

12 December 2020

Pharmacokinetics of mivacurium in normal patients and in those with hepatic or renal failure

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12 December 2020

Disposition of oral metronidazole in hepatic cirrhosis and in hepatosplenic schistosomiasis

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12 December 2020

Comparison of adinazolam pharmacokinetics and effects in healthy and cirrhotic subjects.

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12 December 2020

Interaction between oral hydralazine and propranolol. I. Changes in absorption, presystemic clearance and splanchnic blood flow

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12 December 2020

Localization of uridine 5'-diphosphate-glucuronosyltransferase in human liver injury

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12 December 2020

Central nervous system toxicity associated with meperidine use in hepatic disease

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12 December 2020

Kinetics and dynamics of enalapril in patients with liver cirrhosis

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12 December 2020

Cetirizine pharmacokinetics and pharmacodynamics in primary biliary cirrhosis

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12 December 2020

The pharmacokinetics of enalapril in patients with compensated liver cirrhosis

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12 December 2020

Antipyrine kinetics in patients with primary biliary cirrhosis

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12 December 2020

Hepatic vascular bed.

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12 December 2020

Determinants of hepatic function in liver cirrhosis in the rat. Multivariate analysis

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12 December 2020

Pharmacokinetics of the three isomers of mivacurium and pharmacodynamics of the chiral mixture in hepatic cirrhosis.

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12 December 2020

Unpredictability of clinical evaluation of renal function in cirrhosis. Prospective study

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12 December 2020

Antipyrine clearance per unit liver volume in cirrhotics with and without hepatocellular carcinoma indicating a correlation with histological change of the liver

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12 December 2020

Tubular sodium handling in cirrhotic patients with ascites as analysed by the renal lithium clearance method

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12 December 2020

Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease

1 reference

12 December 2020

Role of the hepatic artery in the metabolism of phenacetin and acetaminophen: intravital microscopic and multiple-indicator dilution study in perfused rat liver

1 reference

12 December 2020

Antipyrine clearance and metabolite excretion in patients with chronic hepatitis C

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12 December 2020

Assessment of lidocaine metabolite formation in comparison with other quantitative liver function tests.

1 reference

12 December 2020

Is glucuronidation truly preserved in patients with liver disease?

1 reference

12 December 2020

Oral pharmacokinetics and ascitic fluid penetration of ofloxacin in cirrhosis

1 reference

12 December 2020

Fleroxacin pharmacokinetics in patients with liver cirrhosis

1 reference

12 December 2020

Single-dose pharmacokinetics of fluconazole in patients with liver cirrhosis

1 reference

12 December 2020

Multiple-dose pharmacokinetics of rufloxacin in patients with cirrhosis

1 reference

12 December 2020

Assessment of liver microcirculation in human cirrhosis

1 reference

12 December 2020

Pharmacokinetics of methylprednisolone hemisuccinate and methylprednisolone in chronic liver disease

1 reference

12 December 2020

Nicardipine infusion improved hepatic function but failed to reduce hepatic venous pressure gradient in patients with cirrhosis

1 reference

12 December 2020

Fluoxetine disposition and elimination in cirrhosis

1 reference

12 December 2020

Disposition of carvedilol enantiomers in patients with liver cirrhosis: evidence for disappearance of stereoselective first-pass extraction

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12 December 2020

Triazolam in cirrhosis: pharmacokinetics and pharmacodynamics

1 reference

12 December 2020

The role of capillarization in hepatic failure: studies in carbon tetrachloride-induced cirrhosis

1 reference

12 December 2020

Ibuprofen and sulindac kinetics in alcoholic liver disease

1 reference

12 December 2020

Nicardipine increases hepatic blood flow and the hepatic clearance of indocyanine green in patients with cirrhosis.

1 reference

12 December 2020

The influence of chronic lobular hepatitis on pharmacokinetics of cefoperazone--a novel galactose single-point method as a measure of residual liver function

1 reference

12 December 2020

Pharmacokinetics and protein binding of cefpiramide in patients with alcoholic cirrhosis

1 reference

12 December 2020

Pharmacokinetics of famotidine after intravenous administration in liver disease

1 reference

12 December 2020

Both phenolic and acyl glucuronidation pathways of diflunisal are impaired in liver cirrhosis

1 reference

12 December 2020

Differential effects of hypoxia on the disposition of propranolol and sodium taurocholate by the isolated perfused rat liver

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12 December 2020

The pharmacokinetics of perindopril in patients with liver cirrhosis

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12 December 2020

Oral Disposition Kinetics of Ofloxacin in Patients with Compensated Liver Cirrhosis

1 reference

12 December 2020

CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients

1 reference

12 December 2020

Antipyrine clearance per unit volume liver: an assessment of hepatic function in chronic liver disease

1 reference

12 December 2020

Pharmacokinetics of aztreonam in patients with liver cirrhosis and ascites

1 reference

12 December 2020

Kinetics of intravenous metoclopramide in patients with hepatic cirrhosis

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12 December 2020

Indocyanine green (ICG) test before and after exercise in patients with chronic liver diseases

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12 December 2020

Prediction of creatinine clearance from serum creatinine

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12 December 2020

D-propoxyphene and norpropoxyphene kinetics after the oral administration of D-propoxyphene: a new approach to liver function?

1 reference

12 December 2020

Transection of the oesophagus for bleeding oesophageal varices

1 reference

12 December 2020

Decreased hepatic function in patients with hepatoma or liver metastasis monitored by a hepatocyte specific galactosylated radioligand

1 reference

12 December 2020

Pharmacokinetics of cefodizime in patients with liver cirrhosis and ascites

1 reference

12 December 2020

Bioavailability, pharmacokinetics, and pharmacodynamics of torsemide in patients with cirrhosis

1 reference

12 December 2020

Pharmacokinetics of temocapril, an ACE inhibitor with preferential biliary excretion, in patients with impaired liver function

1 reference

12 December 2020

Disposition of antipyrine in patients with extensive metastatic liver disease

1 reference

12 December 2020

Disposition of ibuprofen in patients with liver cirrhosis. Stereochemical considerations

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12 December 2020

Propranolol disposition in patients with hepatosplenic schistosomiasis

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12 December 2020

Direct evidence for the intact hepatocyte theory in patients with liver cirrhosis.

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12 December 2020

Hepatic microcirculation in the perfused cirrhotic rat liver

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12 December 2020

Pharmacodynamics of mivacurium chloride in patients with hepatic cirrhosis.

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12 December 2020

Presinusoidal and proximal intrasinusoidal confluence of hepatic artery and portal vein in rat liver: functional evidence by orthograde and retrograde bivascular perfusion.

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12 December 2020

Comparison of in vitro and in vivo biotransformation in patients with liver disease of differing severity

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12 December 2020

Spironolactone pharmacokinetics and pharmacodynamics in patients with cirrhotic ascites

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12 December 2020

Delayed gastric emptying in patients with liver cirrhosis

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12 December 2020

Oxamniquine pharmacokinetics in hepatosplenic schistosomiasis in the Sudan

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of pipecuronium in patients with cirrhosis.

1 reference

12 December 2020

The erythromycin breath test selectively measures P450IIIA in patients with severe liver disease

1 reference

12 December 2020

Protein Binding and Kinetics of Drugs in Liver Diseases

1 reference

12 December 2020

Clinical pharmacokinetics in patients with liver disease

1 reference

12 December 2020

Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples

1 reference

12 December 2020

Pharmacokinetics of flunitrazepam following single dose oral administration in liver disease patients compared with healthy volunteers

1 reference

12 December 2020

Propranolol disposition in chronic liver disease: a physiological approach

1 reference

12 December 2020

Tubular site of renal sodium retention in ascitic liver cirrhosis evaluated by lithium clearance

1 reference

12 December 2020

Disposition kinetics and concentration-effect relationship of metipranolol in patients with cirrhosis and healthy subjects.

1 reference

12 December 2020

Angiotensin-converting enzyme (ACE)-inhibition in cirrhosis. Pharmacokinetics and dynamics of the ACE-inhibitor cilazapril (Ro 31-2848)

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of rocuronium in patients with cirrhosis.

1 reference

12 December 2020

Clearance by the liver in cirrhosis. I. Relationship between propranolol metabolism in vitro and its extraction by the perfused liver in the rat

1 reference

12 December 2020

Effect of upper abdominal surgery and cirrhosis upon the pharmacokinetics of methohexital.

1 reference

12 December 2020

A simple useful method for the determination of hepatic function in patients with liver cirrhosis using caffeine and its three major dimethylmetabolites

1 reference

12 December 2020

Assessment of liver metabolic function. Clinical implications

1 reference

12 December 2020

Metabolic clearance rate of arginine vasopressin in patients with cirrhosis

1 reference

12 December 2020

Kinetics of rifampicin and isoniazid administered alone and in combination to normal subjects and patients with liver disease

1 reference

12 December 2020

Epirubicin in hepatocellular carcinoma: pharmacokinetics and clinical activity.

1 reference

12 December 2020

Drug disposition in patients with HBsAg-positive chronic liver disease

1 reference

12 December 2020

Pre-translational regulation of cytochrome P450 genes is responsible for disease-specific changes of individual P450 enzymes among patients with cirrhosis.

1 reference

12 December 2020

The effect of hepatic cirrhosis on the pharmacokinetics and blood pressure response to nicardipine

1 reference

12 December 2020

Pharmacokinetics of encainide in patients with cirrhosis

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12 December 2020

Pharmacokinetics of lomefloxacin in patients with cirrhosis

1 reference

12 December 2020

Enantiomer specific pharmacokinetics

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12 December 2020

P450 enzymes. Inhibition mechanisms, genetic regulation and effects of liver disease

1 reference

12 December 2020

Limitations of serum creatinine level and creatinine clearance as filtration markers in cirrhosis

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12 December 2020

Impairment of drug metabolism in patients with liver cancer

1 reference

12 December 2020

Phenylbutazone and isoniazid metabolism in patients with liver disease in relation to previous drug therapy

1 reference

12 December 2020

Oral administration of clonidine in patients with alcoholic cirrhosis. Hemodynamic and liver function effects

1 reference

12 December 2020

Erosive gastritis and acute gastroduodenal ulcerations as source of upper gastrointestinal bleeding in liver cirrhosis

1 reference

12 December 2020

The disposition of dapsone in cirrhosis

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12 December 2020

Functional and non-functional liver blood flow in patients with liver cirrhosis measured by indocyanine green

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12 December 2020

Differences in metabolic properties among cortisol, prednisolone, and dexamethasone in liver and renal diseases: accelerated metabolism of dexamethasone in renal failure.

1 reference

12 December 2020

Plasma and tissue distribution of bismuth in normal and cirrhotic rats.

1 reference

12 December 2020

Clinical pharmacokinetics of newer antibacterial agents in liver disease

1 reference

12 December 2020

Clearance by the liver in cirrhosis. II. Characterization of propranolol uptake with the multiple-indicator dilution technique

1 reference

12 December 2020

The pharmacokinetics and neuromuscular effects of rocuronium bromide in patients with liver disease

1 reference

12 December 2020

Lack of effect of verapamil and isosorbide dinitrate on the hepatic clearance of indocyanine green in cirrhosis

1 reference

12 December 2020

Hepatic clearances of antipyrine, indocyanine green, and galactose in normal subjects and in patients with chronic liver diseases

1 reference

12 December 2020

Liver blood flow, antipyrine clearance, and antipyrine metabolite formation clearance in patients with chronic active hepatitis and alcoholic cirrhosis

1 reference

12 December 2020

10.2165/00003088-199529050-00005

Identifiers

DOI

1 reference

PubMed ID

8582120

Dimensions Publication ID

25 September 2017

0 references

1 reference

PubMed ID

8582120