Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q40996057)
Watch
English
PI3K/Akt promotes feedforward mTORC2 activation through IKKα.
scientific article published on 25 March 2016
In more languages
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
5008269
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27027448%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
title
PI3K/Akt promotes feedforward mTORC2 activation through IKKα
(English)
1 reference
stated in
Europe PubMed Central
PMCID
5008269
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27027448%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
author
Ricardo J Antonia
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
5008269
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27027448%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
author name string
Han C Dan
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
5008269
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27027448%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
Albert S Baldwin
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMCID
5008269
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27027448%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
language of work or name
English
0 references
publication date
1 April 2016
1 reference
stated in
Europe PubMed Central
PMCID
5008269
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27027448%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
published in
Oncotarget
1 reference
stated in
Europe PubMed Central
PMCID
5008269
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27027448%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
volume
7
1 reference
stated in
Europe PubMed Central
PMCID
5008269
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27027448%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
issue
16
1 reference
stated in
Europe PubMed Central
PMCID
5008269
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27027448%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
page(s)
21064-21075
1 reference
stated in
Europe PubMed Central
PMCID
5008269
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27027448%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
cites work
PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
Regulation of mTORC1 by PI3K signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
IKK/nuclear factor-kappaB and oncogenesis: roles in tumor-initiating cells and in the tumor microenvironment
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
IKK interacts with rictor and regulates mTORC2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
mTOR signaling in growth control and disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
NF-κB and the link between inflammation and cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
NF-κB, the first quarter-century: remarkable progress and outstanding questions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
Multiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
mTOR: from growth signal integration to cancer, diabetes and ageing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
Oncogenic activation of NF-kappaB.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
Differential involvement of IkappaB kinases alpha and beta in cytokine- and insulin-induced mammalian target of rapamycin activation determined by Akt.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
The two TORCs and Akt.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
Ras, PI(3)K and mTOR signalling controls tumour cell growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
Akt-regulated pathways in prostate cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
The Akt-mTOR tango and its relevance to cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
TSC2: filling the GAP in the mTOR signaling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
Rheb fills a GAP between TSC and TOR.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5008269
retrieved
25 September 2017
Identifiers
DOI
10.18632/ONCOTARGET.8383
1 reference
stated in
Europe PubMed Central
PMCID
5008269
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27027448%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
PMCID
5008269
1 reference
stated in
Europe PubMed Central
PMCID
5008269
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27027448%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
PubMed ID
27027448
1 reference
stated in
Europe PubMed Central
PMCID
5008269
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27027448%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 March 2020
ResearchGate publication ID
299432797
0 references
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit
