(Q41006885)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748564%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

review article

1 reference

title

Transgenic systems in studies on genotoxicity of alkylating agents: critical lesions, thresholds and defense mechanisms (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748564%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

1 reference

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748564%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

author name string

B Kaina

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748564%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

G Fritz

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748564%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

K Ochs

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748564%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

S Haas

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748564%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

T Grombacher

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748564%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

J Dosch

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748564%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

M Christmann

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748564%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

C M Gregel

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748564%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

K Becker

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748564%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

language of work or name

English

0 references

publication date

1 September 1998

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748564%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748564%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

volume

405

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748564%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748564%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

page(s)

179-191

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748564%20AND%20SRC:MED&resulttype=core&format=json

Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents

4 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Contribution of O6-alkylguanine and N-alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: new insights gained from studies of genetically engineered mammalian cell lines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Transfection and expression of human O6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Quantitative comparison of carcinogenicity, mutagenicity and electrophilicity of 10 direct-acting alkylating agents and of the initial O6:7-alkylguanine ratio in DNA with carcinogenic potency in rodents.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Persistence of O 6-Ethylguanine in Rat-Brain DNA: Correlation with Nervous System-Specific Carcinogenesis by Ethylnitrosourea

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Relationship between O6-alkylguanine-DNA alkyltransferase activity and N-methyl-N'-nitro-N-nitrosoguanidine-induced mutation, transformation, and cytotoxicity in C3H/10T1/2 cells expressing exogenous alkyltransferase genes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Repair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosourea

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

High incidence of nitrosamine-induced tumorigenesis in mice lacking DNA repair methyltransferase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Dependency of the yield of sister-chromatid exchanges induced by alkylating agents on fixation time. Possible involvement of secondary lesions in sister-chromatid exchange induction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Chromosome aberrations: persistence of alkylation damage and modulation by O6-alkylguanine-DNA alkyltransferase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

DNA polymerase beta conducts the gap-filling step in uracil-initiated base excision repair in a bovine testis nuclear extract.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Instability and decay of the primary structure of DNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Substrate specificity of 3-methyladenine-DNA glycosylase from calf thymus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

3T3 NIH murine fibroblasts and B78 murine melanoma cells expressing the Escherichia coli N3-methyladenine-DNA glycosylase I do not become resistant to alkylating agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Increased resistance of the Chinese hamster mutant irs1 cells to monofunctional alkylating agents by transfection of the E. coli or mammalian N3-methyladenine-DNA-glycosylase genes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Suppression of human DNA alkylation-repair defects by Escherichia coli DNA-repair genes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Expression in mammalian cells of a truncated Escherichia coli gene coding for O6-alkylguanine alkyltransferase reduces the toxic effects of alkylating agents.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Overexpression of human DNA repair protein N-methylpurine-DNA glycosylase results in the increased removal of N-methylpurines in DNA without a concomitant increase in resistance to alkylating agents in Chinese hamster ovary cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Overexpression of N-methylpurine-DNA glycosylase in Chinese hamster ovary cells renders them more sensitive to the production of chromosomal aberrations by methylating agents--a case of imbalanced DNA repair

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Purification and characterization of human 3-methyladenine-DNA glycosylase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Repair of 8-hydroxyguanine in DNA by mammalian N-methylpurine-DNA glycosylase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Two distinct human DNA diesterases that hydrolyze 3′-blocking deoxyribose fragments from oxidized DNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Stable expression in rat glioma cells of sense and antisense nucleic acids to a human multifunctional DNA repair enzyme, APEX nuclease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Expression of yeast but not human apurinic/apyrimidinic endonuclease renders Chinese hamster cells more resistant to DNA damaging agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Requirement of mammalian DNA polymerase-beta in base-excision repair.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Strategic down-regulation of DNA polymerase beta by antisense RNA sensitizes mammalian cells to specific DNA damaging agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Isolation of clones displaying enhanced resistance to methylating agents in O6-methylguanine-DNA methyltransferase-proficient CHO cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Cell killing by various monofunctional alkylating agents in Chinese hamster ovary cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Transfer of human genes conferring resistance to methylating mutagens, but not to UV irradiation and cross-linking agents, into Chinese hamster ovary cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Mismatch G-T binding activity and MSH2 expression is quantitatively related to sensitivity of cells to methylating agents.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Biochemistry and genetics of eukaryotic mismatch repair

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

A mismatch recognition defect in colon carcinoma confers DNA microsatellite instability and a mutator phenotype

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Endogenous DNA adducts: potential and paradox

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Effect of transfection of human poly(ADP-ribose)polymerase in Chinese hamster cells on mutagen resistance.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Functional overexpression of human poly(ADP-ribose) polymerase in transfected rat tumor cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Overexpression of human poly(ADP-ribose) polymerase in transfected hamster cells leads to increased poly(ADP-ribosyl)ation and cellular sensitization to gamma irradiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

trans-dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N'-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyomavirus replicon

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

c-Fos is involved in the cellular defence against the genotoxic effect of UV radiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

Wild-type p53 is a cell cycle checkpoint determinant following irradiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2898%2900135-3

10.1016/S0027-5107(98)00135-3

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9748564%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

1 reference