(Q41016228)

25 September 2017

title

Truncation mutations in the transactivation region of PAX6 result in dominant-negative mutants (English)

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25 September 2017

S Singh

1

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25 September 2017

H K Tang

series ordinal

2

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25 September 2017

J Y Lee

series ordinal

3

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25 September 2017

G F Saunders

series ordinal

4

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25 September 2017

language of work or name

English

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publication date

1 August 1998

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Journal of Biological Chemistry

25 September 2017

published in

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25 September 2017

volume

273

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25 September 2017

issue

34

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25 September 2017

page(s)

21531-21541

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PAX-6 in development and evolution

25 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Squid Pax-6 and eye development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Dissection of the transactivation function of the transcription factor encoded by the eye developmental gene PAX6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

The paired box encodes a second DNA-binding domain in the paired homeo domain protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

DNA-binding and transactivation properties of Pax-6: three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

High resolution crystal structure of a paired (Pax) class cooperative homeodomain dimer on DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Analysis of cis-acting requirements of the Rh3 and Rh4 genes reveals a bipartite organization to rhodopsin promoters in Drosophila melanogaster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Genomic structure, evolutionary conservation and aniridia mutations in the human PAX6 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

The human PAX6 gene is mutated in two patients with aniridia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

PAX6 mutations in aniridia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Mutations in the PAX6 gene in patients with hereditary aniridia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Nonsense mutation in the homeobox region of the aniridia gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Mouse small eye results from mutations in a paired-like homeobox-containing gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

A mutation in the Pax-6 gene in rat small eye is associated with impaired migration of midbrain crest cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Defects of neuronal migration and the pathogenesis of cortical malformations are associated with Small eye (Sey) in the mouse, a point mutation at the Pax-6-locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

21 January 2018

PAX6 mutations reviewed

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Mutations at the PAX6 locus are found in heterogeneous anterior segment malformations including Peters' anomaly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

PAX6 missense mutation in isolated foveal hypoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Functional analysis of paired box missense mutations in the PAX6 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Characterization of quail Pax-6 (Pax-QNR) proteins expressed in the neuroretina

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Induction of the mouse serum amyloid A3 gene by cytokines requires both C/EBP family proteins and a novel constitutive nuclear factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Analysis of the mouse Splotch-delayed mutation indicates that the Pax-3 paired domain can influence homeodomain DNA-binding activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

An alternative splicing event in the Pax-3 paired domain identifies the linker region as a key determinant of paired domain DNA-binding activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

A binding site for Pax proteins regulates expression of the gene for the neural cell adhesion molecule in the embryonic spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Functional inactivation of genes by dominant negative mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Patterning of the Caenorhabditis elegans head region by the Pax-6 family member vab-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Specification of sense-organ identity by a Caenorhabditis elegans Pax-6 homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

The molecular basis of genetic dominance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Transcriptional regulation of the human PAX6 gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Eye development: governed by a dictator or a junta?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Small eye (Sey): Cloning and characterization of the murine homolog of the human aniridia gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

Negative effect of the transcriptional activator GAL4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.34.21531

21 January 2018

Identifiers

DOI

10.1074/JBC.273.34.21531

1 reference

25 September 2017

1 reference