(Q41020661)

English

The src homology 2 and phosphotyrosine binding domains of the ShcC adaptor protein function as inhibitors of mitogenic signaling by the epidermal growth factor receptor

scientific article published on August 1998

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scholarly article

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Europe PubMed Central

25 September 2017

The src homology 2 and phosphotyrosine binding domains of the ShcC adaptor protein function as inhibitors of mitogenic signaling by the epidermal growth factor receptor (English)

1 reference

Europe PubMed Central

25 September 2017

author name string

J P O'Bryan

1

1 reference

Europe PubMed Central

25 September 2017

Q T Lambert

2

1 reference

Europe PubMed Central

25 September 2017

C J Der

3

1 reference

Europe PubMed Central

25 September 2017

language of work or name

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publication date

1 August 1998

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Europe PubMed Central

25 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

25 September 2017

273

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Europe PubMed Central

25 September 2017

20431-20437

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Europe PubMed Central

25 September 2017

32

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Europe PubMed Central

25 September 2017

A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Constitutive phosphorylation of eps8 in tumor cell lines: relevance to malignant transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Interaction of Shc with adaptor protein adaptins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Src homologous and collagen (Shc) protein binds to F-actin and translocates to the cytoskeleton upon nerve growth factor stimulation in PC12 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Interaction of the adaptor protein Shc and the adhesion molecule cadherin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Ras-mediated transcription activation: analysis by transient cotransfection assays

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Biological assays for Ras transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

GTPase-activating protein SH2-SH3 domains induce gene expression in a Ras-dependent fashion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Immune complex kinase assays for mitogen-activated protein kinase and MEK.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Binding specificity and mutational analysis of the phosphotyrosine binding domain of the brain-specific adaptor protein ShcC.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Functional roles of the Shc phosphotyrosine binding and Src homology 2 domains in insulin and epidermal growth factor signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Identification of Residues within the SHC Phosphotyrosine Binding/Phosphotyrosine Interaction Domain Crucial for Phosphopeptide Interaction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Integration of MAP kinase signal transduction pathways at the serum response element

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.32.20431

21 January 2018

Identifiers

10.1074/JBC.273.32.20431

1 reference

Europe PubMed Central

25 September 2017

1 reference

Europe PubMed Central

25 September 2017

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