(Q41062967)

26 September 2017

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title

Interleukin-2 and human immunodeficiency virus infection: pathogenic mechanisms and potential for immunologic enhancement (English)

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26 September 2017

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2

A S Fauci

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26 September 2017

A Kinter

1

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26 September 2017

language of work or name

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1 January 1996

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26 September 2017

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26 September 2017

volume

15

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26 September 2017

issue

1

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26 September 2017

page(s)

1-15

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Increasing viral burden in CD4+ T cells from patients with human immunodeficiency virus (HIV) infection reflects rapidly progressive immunosuppression and clinical disease

26 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FBF02918280

Macrophage-T cell interaction is essential for the induction of p75 interleukin 2 (IL-2) receptor and IL-2 responsiveness in human CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02918280

Changes in natural immunity during the course of HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02918280

Safety and efficacy of polyethylene glycol-modified interleukin-2 and zidovudine in human immunodeficiency virus type 1 infection: a phase I/II study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02918280

Combination therapy for infection due to human immunodeficiency virus type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02918280

Soluble IL-2 receptor in AIDS. Correlation of its serum level with the classification of HIV-induced diseases and its characterization

21 January 2018

1 reference

12 December 2020

Increases in CD4 T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection. A preliminary study

1 reference

12 December 2020

Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging

1 reference

12 December 2020

Use of interleukin-2 in patients with acquired immunodeficiency syndrome

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12 December 2020

Inhibition of HIV-1 RNA production by the diphtheria toxin-related IL-2 fusion proteins DAB486IL-2 and DAB389IL-2.

1 reference

12 December 2020

Zidovudine therapy is associated with an increased capacity of phytohemagglutinin-stimulated cells to express interleukin-2 receptors. Pittsburgh AIDS Clinical Trial Unit

1 reference

12 December 2020

Establishment of a stable, inducible form of human immunodeficiency virus type 1 DNA in quiescent CD4 lymphocytes in vitro

1 reference

12 December 2020

Cytotoxic T lymphocytes from HIV-1 seropositive individuals recognize immunodominant epitopes in Gp160 and reverse transcriptase

1 reference

12 December 2020

Susceptibility of normal human lymphocytes to infection with HTLV-III/LAV.

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12 December 2020

Cytokine gene expression in HIV-infected intestinal mucosa

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12 December 2020

Regulatory effects of T cell lymphokines on cytokine gene expression in monocytes

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12 December 2020

Biological and biochemical characterization of a factor produced spontaneously by adherent cells of human immunodeficiency virus-infected patients inhibiting interleukin-2 receptor alpha chain (Tac) expression on normal T cells

1 reference

12 December 2020

Unusually high frequencies of HIV-specific cytotoxic T lymphocytes in humans

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12 December 2020

Programmed cell death in AIDS-related HIV and SIV infections.

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12 December 2020

Constitutive expression of human immunodeficiency virus type 1 tat gene inhibits interleukin 2 and interleukin 2 receptor expression in a human CD4+ T lymphoid (H9) cell line

1 reference

12 December 2020

Cytokine network and acute primary HIV-1 infection.

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12 December 2020

Pathogenesis of the natural killer cell deficiency in AIDS.

1 reference

12 December 2020

Treatment of immunodeficiency with interleukin-2: initial exploration

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12 December 2020

Interleukin 2 induces CD8+ T cell-mediated suppression of human immunodeficiency virus replication in CD4+ T cells and this effect overrides its ability to stimulate virus expression

1 reference

12 December 2020

Programmed death of T cells in HIV-1 infection

1 reference

12 December 2020

Multifactorial nature of human immunodeficiency virus disease: implications for therapy

1 reference

12 December 2020

Effect of interleukin-1 on the augmentation of human immunodeficiency virus gene expression

1 reference

12 December 2020

A case for cytokines as effector molecules in the resolution of virus infection

1 reference

12 December 2020

Inhibition of lymphokine-activated killer activity during HIV infection: role of HIV-1 gp41 synthetic peptides

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12 December 2020

Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro

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12 December 2020

Limiting dilution analysis of interleukin-2-producing T cells responsive to recall and alloantigens in human immunodeficiency virus-infected and uninfected individuals

1 reference

12 December 2020

Defective clonogenic potential of CD8+ T lymphocytes in patients with AIDS. Expansion in vivo of a nonclonogenic CD3+CD8+DR+CD25- T cell population.

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12 December 2020

Preliminary clinical observations with recombinant interleukin-2 in patients with AIDS or LAS.

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12 December 2020

Recombinant interleukin-2-induced polyclonal proliferation of in vitro unstimulated human peripheral blood lymphocytes

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12 December 2020

High percentages of CD4-positive lymphocytes harbor the HIV-1 provirus in the blood of certain infected individuals

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12 December 2020

T-cell dysfunction in HIV infection: anergy due to defective antigen-presenting cell function?

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12 December 2020

HIV-1 gp120 and anti-gp120 induce reversible unresponsiveness in peripheral CD4 T lymphocytes.

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12 December 2020

Interleukin-2 enhances the depressed natural killer and cytomegalovirus-specific cytotoxic activities of lymphocytes from patients with the acquired immune deficiency syndrome

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12 December 2020

Interleukin-2 enhances production in 24 hours of infectious human immunodeficiency virus type 1 in vitro by naturally infected mononuclear cells from seropositive donors

1 reference

12 December 2020

CD8+ cell anti-HIV activity: nonlytic suppression of virus replication

1 reference

12 December 2020

Elevated IFN-gamma and decreased IL-2 gene expression are associated with HIV infection

1 reference

12 December 2020

Common subunits of cytokine receptors and the functional redundancy of cytokines

1 reference

12 December 2020

Intrathecal synthesis of interleukin-2 and soluble IL-2 receptor in asymptomatic HIV-1 seropositive individuals. Correlation with local production of specific IgM and IgG antibodies

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12 December 2020

A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes

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12 December 2020

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

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12 December 2020

Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro.

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12 December 2020

Selective elimination of HIV-1-infected cells with an interleukin-2 receptor-specific cytotoxin

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12 December 2020

Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression

1 reference

12 December 2020

Role of LFA-1/ICAM-1 in interleukin-2-stimulated lymphocyte proliferation

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12 December 2020

Peripheral blood dendritic cells in persons with AIDS and AIDS related complex: loss of high intensity class II antigen expression and function

1 reference

12 December 2020

Active nuclear import of human immunodeficiency virus type 1 preintegration complexes

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12 December 2020

Lack of correlation between phenotype activation markers of CD8 lymphocytes and cytotoxic T lymphocyte (CTL) function in HIV-1 infection: evidence for rescue with rIL-2.

1 reference

12 December 2020

Mechanism of defective NK cell activity in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. I. Defective trigger on NK cells for NKCF production by target cells, and partial restoration by IL 2.

1 reference

12 December 2020

Stimulation of a human T-cell clone with anti-CD3 or tumor necrosis factor induces NF-kappa B translocation but not human immunodeficiency virus 1 enhancer-dependent transcription

1 reference

12 December 2020

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

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12 December 2020

Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men. HIV affects the immune system before CD4+ T helper cell depletion occurs

1 reference

12 December 2020

HIV replication in IL-2-stimulated peripheral blood mononuclear cells is driven in an autocrine/paracrine manner by endogenous cytokines

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12 December 2020

Safety and effects of interleukin-2 plus zidovudine in asymptomatic individuals infected with human immunodeficiency virus.

1 reference

12 December 2020

Human immunodeficiency virus Tat induces functional unresponsiveness in T cells

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12 December 2020

Convergent combination therapy can select viable multidrug-resistant HIV-1 in vitro

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12 December 2020

Increased synthesis and production of prostaglandin E2 by monocytes from drug addicts with AIDS

1 reference

12 December 2020

Analysis of the basis of resistance and susceptibility of CD4+ T cells to human immunodeficiency virus (HIV)-gp120 induced anergy

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12 December 2020

The IL-2/IL-2 receptor system: a target for rational immune intervention

1 reference

12 December 2020

Production of interleukins in human immunodeficiency virus-1-replicating lymph nodes

1 reference

12 December 2020

Effect of cytokines on HIV release and IL-2 receptor alpha expression in monocytic cell lines

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12 December 2020

The immunopathogenesis of human immunodeficiency virus infection

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12 December 2020

Apoptosis in HIV infection: protective role of IL-2

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12 December 2020

An HIV-1-infected T cell clone defective in IL-2 production and Ca2+ mobilization after CD3 stimulation.

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12 December 2020

Defective monocyte function in acquired immune deficiency syndrome (AIDS): evidence from a monocyte-dependent T-cell proliferative system

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12 December 2020

Correlation of T and B cell activities in vitro and serum IL-2 levels in systemic lupus erythematosus

1 reference

12 December 2020

The human immunodeficiency virus type-1 long terminal repeat and its role in gene expression

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12 December 2020

Regulation of HIV production by blood mononuclear cells from HIV-infected donors: II. HIV-1 production depends on T cell-monocyte interaction

1 reference

12 December 2020

Long-term cultures of HTLV-III--infected T cells: a model of cytopathology of T-cell depletion in AIDS.

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12 December 2020

Immunological abnormalities in the natural history of HIV infection: mechanisms and clinical relevance

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12 December 2020

Down-Regulation of Interleukin-2 Receptor Gene Activation and Protein Expression by Dideoxynucleoside Analogs

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12 December 2020

Expression of interleukin 2 receptors by monocytes from patients with acquired immunodeficiency syndrome and induction of monocyte interleukin 2 receptors by human immunodeficiency virus in vitro

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12 December 2020

Human recombinant interleukin-2 partly reconstitutes deficient in-vitro immune responses of lymphocytes from patients with AIDS

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12 December 2020

Cytotoxic T lymphocytes against HIV

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12 December 2020

Effects of systemic in vivo interleukin-2 (IL-2) reconstitution in patients with acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC) on phenotypes and functions of peripheral blood mononuclear cells (PBMC)

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12 December 2020

Blocked early-stage latency in the peripheral blood cells of certain individuals infected with human immunodeficiency virus type 1

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12 December 2020

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

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12 December 2020

Functional dichotomy of CD4+ T helper lymphocytes in asymptomatic human immunodeficiency virus infection

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12 December 2020

Synthetic peptides corresponding to sequences in HIV envelope gp41 and gp120 enhance in vitro production of interleukin-1 and tumor necrosis factor but depress production of interferon-alpha, interferon-gamma and interleukin-2.

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12 December 2020

HIV promoter activity in primary antigen-specific human T lymphocytes

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12 December 2020

Prolonged immunostimulatory effect of low-dose polyethylene glycol interleukin 2 in patients with human immunodeficiency virus type 1 infection

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12 December 2020

Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals

1 reference

12 December 2020

Patients with HIV infection have a reduced proportion of lymphocytes expressing the IL2 receptor p55 chain (TAC, CD25)

1 reference

12 December 2020

Both a precursor and a mature population of dendritic cells can bind HIV. However, only the mature population that expresses CD80 can pass infection to unstimulated CD4+ T cells

1 reference

12 December 2020

Tumor necrosis factor alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kappa B sites in the long terminal repeat

1 reference

12 December 2020

HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure

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12 December 2020

1 reference

12 December 2020

Longitudinal study of leukocyte functions in homosexual men seroconverted for HIV: rapid and persistent loss of B cell function after HIV infection

1 reference

12 December 2020

Analysis of apoptosis in lymph nodes of HIV-infected persons. Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden

1 reference

12 December 2020

Systemic administration of interleukin-2 in humans

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12 December 2020

CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication

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12 December 2020

Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia.

1 reference

12 December 2020

Serum increases and lymphoid cell surface losses of IL-2 receptor CD25 in HIV infection: Distinctive parameters of HIV-induced change

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12 December 2020

Role of CD25+ and CD25-T cells in acute HIV infection in vitro

1 reference

12 December 2020

Soluble IL-2 receptor in rheumatoid arthritis. Correlation with disease activity, IL-1 and IL-2 inhibition

1 reference

12 December 2020

The impaired in vitro production of interleukin-2 in HIV infection is negatively correlated to the number of circulating CD4+DR+ T cells and is reversed by allowing T cells to rest in culture: arguments for in vivo CD4+ T cell activation

1 reference

12 December 2020

Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS

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12 December 2020

Ex vivo expansion of HIV type 1-specific cytolytic T cells from HIV type 1-seropositive subjects

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12 December 2020

Expression of CD25 defines peripheral blood mononuclear cells with productive versus latent HIV infection

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12 December 2020

Differential regulation of lymphokine production by distinct subunits of the T cell interleukin 2 receptor

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12 December 2020

Secondary cytokine production by lymphoid cells used in cellular immunotherapy

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12 December 2020

Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS)

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12 December 2020

High cerebrospinal fluid and serum levels of tumor necrosis factor-alpha in asymptomatic HIV-1 seropositive individuals. Correlation with interleukin-2 and soluble IL-2 receptor.

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12 December 2020

Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection

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12 December 2020

Inhibition of antigen-induced lymphocyte proliferation by Tat protein from HIV-1.

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12 December 2020

Cellular tropism of the human retrovirus HTLV-III/LAV. I. Role of T cell activation and expression of the T4 antigen.

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12 December 2020

Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines.

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12 December 2020

Functional and phenotypic evidence for a selective loss of memory T cells in asymptomatic human immunodeficiency virus-infected men

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12 December 2020

Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals

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12 December 2020

Defective T-cell response to PHA and mitogenic monoclonal antibodies in male homosexuals with acquired immunodeficiency syndrome and its in vitro correction by interleukin 2

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12 December 2020

Human immunodeficiency virus type 1 2-LTR circles reside in a nucleoprotein complex which is different from the preintegration complex.

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12 December 2020

T-cell death by apoptosis in vertically human immunodeficiency virus-infected children coincides with expansion of CD8+/interleukin-2 receptor-/HLA-DR+ T cells: sign of a possible role for herpes viruses as cofactors?

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12 December 2020

Impaired interleukin 12 production in human immunodeficiency virus-infected patients

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12 December 2020

Highly purified quiescent human peripheral blood CD4+ T cells are infectible by human immunodeficiency virus but do not release virus after activation

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12 December 2020

Serum levels of IL-2, IL-1 alpha, TNF-alpha, and soluble receptor of IL-2 in HIV-1-infected patients

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12 December 2020

Rapid Il-2-induced adherence of human natural killer cells. Expression of mRNA for cytokines and IL-2 receptors in adherent NK cells

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12 December 2020

Ability of HIV to promote a TH1 to TH0 shift and to replicate preferentially in TH2 and TH0 cells

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12 December 2020

A model for the selective loss of major histocompatibility complex self-restricted T cell immune responses during the development of acquired immune deficiency syndrome (AIDS).

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12 December 2020

Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome. Evidence for a selective defect in soluble antigen recognition

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12 December 2020

Human immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNA

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12 December 2020

Selective loss of T cell functions in different stages of HIV infection. Early loss of anti-CD3-induced T cell proliferation followed by decreased anti-CD3-induced cytotoxic T lymphocyte generation in AIDS-related complex and AIDS.

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12 December 2020

Anergy and apoptosis in CD8+ T cells from HIV-infected persons

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12 December 2020

Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle

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12 December 2020

Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis

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12 December 2020

Interleukin-2 in the treatment of HIV disease

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12 December 2020

Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA.

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12 December 2020

Use of evolutionary limitations of HIV-1 multidrug resistance to optimize therapy.

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12 December 2020

Viral dynamics in human immunodeficiency virus type 1 infection

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12 December 2020

The Th1-Th2 hypothesis of HIV infection: new insights

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12 December 2020

Suboptimal and optimal activation signals modulate differently the expression of HIV-1 and cytokine genes

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12 December 2020

Defective natural immunity: an early manifestation of human immunodeficiency virus infection

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12 December 2020

Identifiers

DOI

10.1007/BF02918280

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Dimensions Publication ID

26 September 2017

1008190414

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