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How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication.
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Europe PubMed Central
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5222725
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27989442%20AND%20SRC:MED&resulttype=core&format=json
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30 March 2020
title
How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication
(English)
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5222725
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30 March 2020
author
John Francis Xavier Diffley
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4
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5222725
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30 March 2020
author name string
Joseph T P Yeeles
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1
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5222725
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30 March 2020
Agnieska Janska
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2
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30 March 2020
Anne Early
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3
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30 March 2020
publication date
15 December 2016
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30 March 2020
published in
Molecular Cell
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5222725
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27989442%20AND%20SRC:MED&resulttype=core&format=json
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30 March 2020
volume
65
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30 March 2020
issue
1
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30 March 2020
page(s)
105-116
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30 March 2020
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PubMed Central
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Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation
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Recruitment of Mcm10 to Sites of Replication Initiation Requires Direct Binding to the Minichromosome Maintenance (MCM) Complex
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A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands
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Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation.
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26 September 2017
CMG helicase and DNA polymerase ε form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication.
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26 September 2017
Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork.
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26 September 2017
Helicase activation and establishment of replication forks at chromosomal origins of replication.
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High-resolution mapping, characterization, and optimization of autonomously replicating sequences in yeast.
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Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation
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GINS motion reveals replication fork progression is remarkably uniform throughout the yeast genome.
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26 September 2017
A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication
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26 September 2017
Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing
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26 September 2017
Csm3, Tof1, and Mrc1 form a heterotrimeric mediator complex that associates with DNA replication forks
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PubMed Central
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26 September 2017
A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome.
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26 September 2017
The direct binding of Mrc1, a checkpoint mediator, to Mcm6, a replication helicase, is essential for the replication checkpoint against methyl methanesulfonate-induced stress
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26 September 2017
Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpoint
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26 September 2017
Division of labor at the eukaryotic replication fork
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PubMed Central
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26 September 2017
Claspin promotes normal replication fork rates in human cells
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26 September 2017
The eukaryotic leading and lagging strand DNA polymerases are loaded onto primer-ends via separate mechanisms but have comparable processivity in the presence of PCNA.
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PubMed Central
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26 September 2017
Mrc1 and Tof1 regulate DNA replication forks in different ways during normal S phase
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PubMed Central
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26 September 2017
Replication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cells
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26 September 2017
Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast.
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PubMed Central
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26 September 2017
CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast
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26 September 2017
Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase
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PubMed Central
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26 September 2017
Distinct roles for Sld3 and GINS during establishment and progression of eukaryotic DNA replication forks
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5222725
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26 September 2017
GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5222725
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26 September 2017
The Tof1p-Csm3p protein complex counteracts the Rrm3p helicase to control replication termination of Saccharomyces cerevisiae
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5222725
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26 September 2017
Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5222725
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26 September 2017
Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5222725
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26 September 2017
Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5222725
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26 September 2017
swi1- and swi3-dependent and independent replication fork arrest at the ribosomal DNA of Schizosaccharomyces pombe
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5222725
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26 September 2017
S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5222725
retrieved
26 September 2017
In vivo reconstitution of Saccharomyces cerevisiae DNA polymerase epsilon in insect cells. Purification and characterization
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5222725
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26 September 2017
Cell-Cycle-Regulated Interaction between Mcm10 and Double Hexameric Mcm2-7 Is Required for Helicase Splitting and Activation during S Phase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5222725
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26 September 2017
Regulated eukaryotic DNA replication origin firing with purified proteins
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5222725
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14 June 2018
Intrinsic coupling of lagging-strand synthesis to chromatin assembly.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5222725
retrieved
14 June 2018
DNA polymerase epsilon catalytic domains are dispensable for DNA replication, DNA repair, and cell viability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5222725
retrieved
14 June 2018
Coordinated leading and lagging strand synthesis during SV40 DNA replication in vitro requires PCNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5222725
retrieved
14 June 2018
Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5222725
retrieved
19 August 2018
Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5222725
retrieved
19 August 2018
Ctf4 coordinates the progression of helicase and DNA polymerase alpha.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5222725
retrieved
19 August 2018
Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5222725
retrieved
19 August 2018
Mrc1 is required for normal progression of replication forks throughout chromatin in S. cerevisiae.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5222725
retrieved
19 August 2018
swi1 and swi3 perform imprinting, pausing, and termination of DNA replication in S. pombe.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5222725
retrieved
19 August 2018
Identifiers
DOI
10.1016/J.MOLCEL.2016.11.017
1 reference
stated in
Europe PubMed Central
PMCID
5222725
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27989442%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 March 2020
PMCID
5222725
1 reference
stated in
Europe PubMed Central
PMCID
5222725
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27989442%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 March 2020
PubMed ID
27989442
1 reference
stated in
Europe PubMed Central
PMCID
5222725
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27989442%20AND%20SRC:MED&resulttype=core&format=json
retrieved
30 March 2020
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