(Q41085989)

26 September 2017

Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability (English)

1 reference

26 September 2017

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27150430%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Martino Bolognesi

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27150430%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Benedetta Maria Sala

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27150430%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Pietro Sormanni

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27150430%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Alessandra Corazza

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27150430%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Matteo de Rosa

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27150430%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Alberto Barbiroli

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27150430%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

V Bellotti

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27150430%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Michele Vendruscolo

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27150430%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Stefano Ricagno

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27150430%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

4

Riccardo Porcari

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27150430%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

author name string

Stefano Zanini

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27150430%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Gennaro Esposito

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27150430%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

language of work or name

English

0 references

publication date

6 May 2016

1 reference

26 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27150430%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27150430%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

page(s)

25559

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27150430%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

5 June 2020

copyright license

start time

1 May 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/srep25559

0 references

cites work

Decoding the Structural Bases of D76N ß2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Replica-Averaged Metadynamics

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Wild type beta-2 microglobulin and DE loop mutants display a common fibrillar architecture

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Edge strand engineering prevents native-like aggregation in Sulfolobus solfataricus acylphosphatase

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

The amyloid state and its association with protein misfolding diseases.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic β 2 -Microglobulin

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Hereditary systemic amyloidosis due to Asp76Asn variant β2-microglobulin

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Structure of an intermediate state in protein folding and aggregation

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Structure, stability, and aggregation of β-2 microglobulin mutants: insights from a Fourier transform infrared study in solution and in the crystalline state

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Characterization of the conformational equilibrium between the two major substates of RNase A using NMR chemical shifts

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Proteome folding and aggregation

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

A recurrent D-strand association interface is observed in β-2 microglobulin oligomers

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Experimental free energy surfaces reveal the mechanisms of maintenance of protein solubility

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

The two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

D-strand perturbation and amyloid propensity in beta-2 microglobulin

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Cellular strategies for controlling protein aggregation

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

PHENIX: a comprehensive Python-based system for macromolecular structure solution

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Physicochemical principles that regulate the competition between functional and dysfunctional association of proteins

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Human beta-2 microglobulin W60V mutant structure: Implications for stability and amyloid aggregation

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

The Zyggregator method for predicting protein aggregation propensities

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

A bias-exchange approach to protein folding

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Molecular dynamics simulation suggests possible interaction patterns at early steps of beta2-microglobulin aggregation.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Scaling and assessment of data quality

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Coot: model-building tools for molecular graphics

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

The CCP4 suite: programs for protein crystallography

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Protein folding and misfolding

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Rationalization of the effects of mutations on peptide and protein aggregation rates.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Molecular mechanisms of amyloidosis

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Prevention of transthyretin amyloid disease by changing protein misfolding energetics.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

The role of disulfide bond in the amyloidogenic state of beta(2)-microglobulin studied by heteronuclear NMR.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

The solution structure of human β2-microglobulin reveals the prodromes of its amyloid transition

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca(2+) stabilization

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

beta2-microglobulin-derived amyloidosis: an update

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Protein misfolding, evolution and disease

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

1H, 13C and 15N chemical shift referencing in biomolecular NMR

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Structure of the human class I histocompatibility antigen, HLA-A2

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

DE-loop mutations affect beta2 microglobulin stability, oligomerization, and the low-pH unfolded form

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Removal of the N-terminal hexapeptide from human beta2-microglobulin facilitates protein aggregation and fibril formation

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

The CamSol method of rational design of protein mutants with enhanced solubility.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Reduction of conformational mobility and aggregation in W60G β2-microglobulin: assessment by 15N NMR relaxation.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Sequence-based prediction of protein solubility.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Folding and fibrillogenesis: clues from beta2-microglobulin.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Fibril growth kinetics reveal a region of beta2-microglobulin important for nucleation and elongation of aggregation

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

The degree of structural protection at the edge beta-strands determines the pathway of amyloid formation in globular proteins

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

A native to amyloidogenic transition regulated by a backbone trigger

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4858664

Replica-exchange molecular dynamics method for protein folding

19 August 2018

1 reference

MOLREP: an Automated Program for Molecular Replacement

21 January 2018

1 reference

Metastability of Native Proteins and the Phenomenon of Amyloid Formation

21 January 2018

1 reference

Life on the edge: a link between gene expression levels and aggregation rates of human proteins

21 January 2018

1 reference

Structural Basis of the Differential Stability and Receptor Specificity of H-2Db in Complex with Murine versus Human β2-Microglobulin

21 January 2018

1 reference

Statistical mechanics of the denatured state of a protein using replica-averaged metadynamics

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27150430

12 December 2020

inferred from PubMed ID database lookup

A new form of amyloid protein associated with chronic hemodialysis was identified as beta 2-microglobulin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27150430

12 December 2020

inferred from PubMed ID database lookup

Molecular dynamics simulations with replica-averaged structural restraints generate structural ensembles according to the maximum entropy principle

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27150430

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/SREP25559

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27150430%20AND%20SRC:MED&resulttype=core&format=json

release_3hrfbfqeprb4vgj3fftss5w4pa

5 June 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/3hrfbfqeprb4vgj3fftss5w4pa

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27150430%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

1 reference