(Q41106970)

English

Regulation of Ubiquitin-like with Plant Homeodomain and RING Finger Domain 1 (UHRF1) Protein Stability by Heat Shock Protein 90 Chaperone Machinery

scientific article published on 3 August 2016

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scholarly article

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Europe PubMed Central

PMC publication ID

26 September 2017

Regulation of Ubiquitin-like with Plant Homeodomain and RING Finger Domain 1 (UHRF1) Protein Stability by Heat Shock Protein 90 Chaperone Machinery (English)

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

molecular chaperones

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author name string

Guangjin Ding

1

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

Peilin Chen

2

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Europe PubMed Central

PMC publication ID

26 September 2017

Hui Zhang

3

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Europe PubMed Central

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26 September 2017

Xiaojie Huang

4

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

Yi Zang

5

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

Jiwen Li

6

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Europe PubMed Central

PMC publication ID

26 September 2017

Jia Li

7

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Europe PubMed Central

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26 September 2017

Jiemin Wong

8

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Europe PubMed Central

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26 September 2017

language of work or name

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publication date

3 August 2016

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Europe PubMed Central

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26 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

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26 September 2017

291

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Europe PubMed Central

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26 September 2017

38

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Europe PubMed Central

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26 September 2017

20125-20135

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Europe PubMed Central

PMC publication ID

26 September 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5025696/fullTextXML

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inferred from PubMed Central ID database lookup

An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1.

1 reference

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26 September 2017

Maximizing the Therapeutic Potential of HSP90 Inhibitors

1 reference

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26 September 2017

DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination

1 reference

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26 September 2017

Accessibility of different histone H3-binding domains of UHRF1 is allosterically regulated by phosphatidylinositol 5-phosphate

1 reference

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26 September 2017

E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells

1 reference

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Roles of F-box proteins in cancer

1 reference

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UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma

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Increasing role of UHRF1 in the reading and inheritance of the epigenetic code as well as in tumorogenesis

1 reference

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26 September 2017

Chaperone machines for protein folding, unfolding and disaggregation

1 reference

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26 September 2017

Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication

1 reference

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26 September 2017

Mechanisms and function of substrate recruitment by F-box proteins.

1 reference

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26 September 2017

DNA damage regulates UHRF1 stability via the SCF(β-TrCP) E3 ligase

1 reference

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26 September 2017

Structural Insight into Coordinated Recognition of Trimethylated Histone H3 Lysine 9 (H3K9me3) by the Plant Homeodomain (PHD) and Tandem Tudor Domain (TTD) of UHRF1 (Ubiquitin-like, Containing PHD and RING Finger Domains, 1) Protein

1 reference

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26 September 2017

Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation

1 reference

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26 September 2017

The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein

1 reference

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26 September 2017

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition

1 reference

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26 September 2017

UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression.

1 reference

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26 September 2017

DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy

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26 September 2017

The Hsp90 chaperone machinery: conformational dynamics and regulation by co-chaperones

1 reference

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26 September 2017

Molecular chaperones in protein folding and proteostasis

1 reference

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26 September 2017

Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage

1 reference

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26 September 2017

UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis

1 reference

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26 September 2017

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

1 reference

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26 September 2017

UHRF1 is a novel diagnostic marker of lung cancer.

1 reference

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26 September 2017

Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction

1 reference

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Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage

1 reference

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26 September 2017

Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase

1 reference

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26 September 2017

Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism

1 reference

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26 September 2017

Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

1 reference

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The Hsp90 molecular chaperone: an open and shut case for treatment

1 reference

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The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

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ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation

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UHRF1 plays a role in maintaining DNA methylation in mammalian cells

1 reference

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26 September 2017

The UHRF family: oncogenes that are drugable targets for cancer therapy in the near future?

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26 September 2017

Chaperone functions of the E3 ubiquitin ligase CHIP.

1 reference

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The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

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HSP90 and the chaperoning of cancer

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Down-regulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transition

1 reference

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Np95 is a histone-binding protein endowed with ubiquitin ligase activity

1 reference

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CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

1 reference

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1 reference

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ErbB2 degradation mediated by the co-chaperone protein CHIP

1 reference

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26 September 2017

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26 September 2017

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

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UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9.

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19 August 2018

Identifiers

10.1074/JBC.M116.727214

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

26 September 2017

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