(Q41134560)

27 September 2017

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title

IL-6 cytokine family and signal transduction: a model of the cytokine system (English)

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27 September 2017

M Hibi

1

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author name string

K Nakajima

series ordinal

2

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PubMed ID

8834766

27 September 2017

T Hirano

series ordinal

3

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27 September 2017

1 January 1996

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Journal of Molecular Medicine

27 September 2017

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27 September 2017

74

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27 September 2017

1-12

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27 September 2017

1

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https://scigraph.springernature.com/pub.10.1007/bf00202068

27 September 2017

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cites work

Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter

1 reference

12 December 2020

Interleukin 6: insights to its function in skin by overexpression in transgenic mice

1 reference

12 December 2020

Regulation of the acute phase and immune responses: interleukin-6

1 reference

12 December 2020

Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation

1 reference

12 December 2020

Cytokine signaling through nonreceptor protein tyrosine kinases

1 reference

12 December 2020

Interleukin 6 and expression of its receptor on epidermal keratinocytes

1 reference

12 December 2020

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes

1 reference

12 December 2020

Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130.

1 reference

12 December 2020

Acute-phase reaction induces a specific complex between hepatic nuclear proteins and the interleukin 6 response element of the rat alpha 2-macroglobulin gene

1 reference

12 December 2020

Interleukin 3-specific tyrosine phosphorylation of a membrane glycoprotein of Mr 150,000 in multi-factor-dependent myeloid cell lines

1 reference

12 December 2020

Recombinant human interleukin 6 (B-cell stimulatory factor 2) is a potent inducer of differentiation of mouse myeloid leukemia cells (M1)

1 reference

12 December 2020

Expression cloning of the murine erythropoietin receptor

1 reference

12 December 2020

Identification of functional receptors for ciliary neurotrophic factor on neuronal cell lines and primary neurons

1 reference

12 December 2020

Distinct sets of acute phase plasma proteins are stimulated by separate human hepatocyte-stimulating factors and monokines in rat hepatoma cells

1 reference

12 December 2020

Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

1 reference

12 December 2020

Inactivation of erythropoietin receptor function by point mutations in a region having homology with other cytokine receptors

1 reference

12 December 2020

Cholinergic neuronotrophic factors: intraocular distribution of trophic activity for ciliary neurons

1 reference

12 December 2020

Expression cloning of a receptor for murine granulocyte colony-stimulating factor

1 reference

12 December 2020

Proliferation and differentiation of embryonic chick sympathetic neurons: effects of ciliary neurotrophic factor.

1 reference

12 December 2020

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

1 reference

12 December 2020

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1 reference

12 December 2020

Transcriptional activation of the IL-6 response element in the junB promoter is mediated by multiple Stat family proteins

1 reference

12 December 2020

Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits

1 reference

12 December 2020

Identification of the second subunit of the murine interleukin-5 receptor: interleukin-3 receptor-like protein, AIC2B is a component of the high affinity interleukin-5 receptor

1 reference

12 December 2020

Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor

1 reference

12 December 2020

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

1 reference

12 December 2020

Haemopoietic receptors and helical cytokines

1 reference

12 December 2020

B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes

1 reference

12 December 2020

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family

1 reference

12 December 2020

The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor

1 reference

12 December 2020

Characterization of interleukin-11 receptor and protein tyrosine phosphorylation induced by interleukin-11 in mouse 3T3-L1 cells

1 reference

12 December 2020

Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family

1 reference

12 December 2020

Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis

1 reference

12 December 2020

Purification of a lipoprotein lipase-inhibiting protein produced by a melanoma cell line associated with cancer cachexia

1 reference

12 December 2020

Structural design and molecular evolution of a cytokine receptor superfamily

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12 December 2020

Released form of CNTF receptor alpha component as a soluble mediator of CNTF responses

1 reference

12 December 2020

Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway

1 reference

12 December 2020

LIF and OM directly interact with a soluble form of gp130, the IL-6 receptor signal transducing subunit

1 reference

12 December 2020

The receptor for ciliary neurotrophic factor

1 reference

12 December 2020

Cloning of the gamma chain of the human IL-2 receptor

1 reference

12 December 2020

Oncostatin M binds the high-affinity leukemia inhibitory factor receptor

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12 December 2020

Direct and synergistic effects of interleukin 11 on murine hemopoiesis in culture

1 reference

12 December 2020

Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture.

1 reference

12 December 2020

Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor

1 reference

12 December 2020

Interleukin-11 regulates the hepatic expression of the same plasma protein genes as interleukin-6

1 reference

12 December 2020

Neuronal differentiation factors/cytokines and synaptic plasticity

1 reference

12 December 2020

Growth inhibition of human breast carcinoma and leukemia/lymphoma cell lines by recombinant interferon-beta 2

1 reference

12 December 2020

Reconstitution of the response to leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in hepatoma cells

1 reference

12 December 2020

Involvement of Janus kinases, p52shc, Raf-1, and MEK-1 in the IL-6-induced mitogen-activated protein kinase cascade of a growth-responsive B cell line.

1 reference

12 December 2020

Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11.

1 reference

12 December 2020

Functional and biochemical association of Hck with the LIF/IL-6 receptor signal transducing subunit gp130 in embryonic stem cells

1 reference

12 December 2020

B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes

1 reference

12 December 2020

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components

1 reference

12 December 2020

IL-6 is produced by osteoblasts and induces bone resorption

1 reference

12 December 2020

Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines

1 reference

12 December 2020

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells

1 reference

12 December 2020

Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes

1 reference

12 December 2020

Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling

1 reference

12 December 2020

Role of CAAT-enhancer binding protein isoforms in the cytokine regulation of acute-phase plasma protein genes

1 reference

12 December 2020

A common nuclear signal transduction pathway activated by growth factor and cytokine receptors

1 reference

12 December 2020

Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells

1 reference

12 December 2020

Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex

1 reference

12 December 2020

The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains

1 reference

12 December 2020

Growth factor requirements for survival in G0 and entry into the cell cycle of primitive human hemopoietic progenitors

1 reference

12 December 2020

The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms.

1 reference

12 December 2020

Interleukin-6-induced tyrosine phosphorylation of multiple proteins in murine hematopoietic lineage cells

1 reference

12 December 2020

IL-6-inducible complexes on an IL-6 response element of the junB promoter contain Stat3 and 36 kDa CRE-like site binding protein(s).

1 reference

12 December 2020

Requirement of serine phosphorylation for formation of STAT-promoter complexes

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12 December 2020

Multiple regions within the cytoplasmic domains of the leukemia inhibitory factor receptor and gp130 cooperate in signal transduction in hepatic and neuronal cells

1 reference

12 December 2020

Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor

1 reference

12 December 2020

Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

1 reference

12 December 2020

Purification of the chick eye ciliary neuronotrophic factor

1 reference

12 December 2020

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

1 reference

12 December 2020

The myeloid blood cell differentiation-inducing protein MGI-2A is interleukin-6.

1 reference

12 December 2020

Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily

1 reference

12 December 2020

Involvement of IL-6 in mesangial proliferative glomerulonephritis

1 reference

12 December 2020

Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors

1 reference

12 December 2020

Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells

1 reference

12 December 2020

Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors

1 reference

12 December 2020

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

1 reference

12 December 2020

Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130

1 reference

12 December 2020

Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's

1 reference

12 December 2020

Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family

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12 December 2020

Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF)

1 reference

12 December 2020

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

1 reference

12 December 2020

Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130

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12 December 2020

Recombinant human B cell stimulatory factor 2 (BSF-2/IFN-beta 2) regulates beta-fibrinogen and albumin mRNA levels in Fao-9 cells

1 reference

12 December 2020

Molecular cloning, sequence analysis, and functional expression of a novel growth regulator, oncostatin M

1 reference

12 December 2020

Human helper T cell factor(s) (ThF). II. Induction of IgG production in B lymphoblastoid cell lines and identification of T cell-replacing factor- (TRF) like factor(s)

1 reference

12 December 2020

AIDS Kaposi sarcoma-derived cells produce and respond to interleukin 6

1 reference

12 December 2020

Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion

1 reference

12 December 2020

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15

1 reference

12 December 2020

Stimulation of factor-dependent myeloid cell lines with interleukin 3 induces tyrosine phosphorylation of several cellular substrates

1 reference

12 December 2020

Ciliary neurotrophic factor induces cholinergic differentiation of rat sympathetic neurons in culture

1 reference

12 December 2020

Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

1 reference

12 December 2020

Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor

1 reference

12 December 2020

Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4

1 reference

12 December 2020

Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus

1 reference

12 December 2020

Identification of the promoter sequences involved in the interleukin-6 dependent expression of the rat alpha 2-macroglobulin gene

1 reference

12 December 2020

Retinoic acid inhibits interleukin-6-induced macrophage differentiation and apoptosis in a murine hematopoietic cell line, Y6

1 reference

12 December 2020

Proliferative action of erythropoietin is associated with rapid protein tyrosine phosphorylation in responsive B6SUt.EP cells

1 reference

12 December 2020

Distinct regions of the human granulocyte-colony-stimulating factor receptor cytoplasmic domain are required for proliferation and gene induction

1 reference

12 December 2020

Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy.

1 reference

12 December 2020

Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy

1 reference

12 December 2020

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6

1 reference

12 December 2020

Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor

1 reference

12 December 2020

Interleukin 2-dependent and interleukin 2-independent pathways of regulation of thymocyte function by interleukin 6.

1 reference

12 December 2020

Signal transduction through IL-6 receptor: involvement of multiple protein kinases, stat factors, and a novel H7-sensitive pathway

1 reference

12 December 2020

Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level

1 reference

12 December 2020

Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6

1 reference

12 December 2020

Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine

1 reference

12 December 2020

Activation of Fes tyrosine kinase by gp130, an interleukin-6 family cytokine signal transducer, and their association

1 reference

12 December 2020

Interleukin-6 signals activating junB and TIS11 gene transcription in a B-cell hybridoma

1 reference

12 December 2020

Molecular cloning and expression of an IL-6 signal transducer, gp130

1 reference

12 December 2020

Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation

1 reference

12 December 2020

A restricted cytoplasmic region of IL-2 receptor beta chain is essential for growth signal transduction but not for ligand binding and internalization

1 reference

12 December 2020

Interleukin-6: an overview

1 reference

12 December 2020

Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines

1 reference

12 December 2020

The role of interleukin-6 in mucosal IgA antibody responses in vivo

1 reference

12 December 2020

Identification of a major growth factor for AIDS-Kaposi's sarcoma cells as oncostatin M

1 reference

12 December 2020

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

1 reference

12 December 2020

Signaling by the cytokine receptor superfamily: JAKs and STATs.

1 reference

12 December 2020

Recombinant oncostatin M stimulates the production of acute phase proteins in HepG2 cells and rat primary hepatocytes in vitro

1 reference

12 December 2020

Generation of sensory neurons is stimulated by leukemia inhibitory factor

1 reference

12 December 2020

A novel family of growth factor receptors: a common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and the p75 IL-2 receptor beta-chain

1 reference

12 December 2020

A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.

1 reference

12 December 2020

Synergism of BSF-2/interleukin 6 and interleukin 3 on development of multipotential hemopoietic progenitors in serum-free culture

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12 December 2020

Interleukin 2-induced tyrosine phosphorylation. Interleukin 2 receptor beta is tyrosine phosphorylated

1 reference

12 December 2020

Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor

1 reference

12 December 2020

CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130

1 reference

12 December 2020

Synergistic action of interleukin-6 and glucocorticoids is mediated by the interleukin-6 response element of the rat alpha 2 macroglobulin gene

1 reference

12 December 2020

Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130

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12 December 2020

Impaired immune and acute-phase responses in interleukin-6-deficient mice.

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12 December 2020

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction

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12 December 2020

Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved

1 reference

12 December 2020

Actions and interactions of G-CSF, LIF, and IL-6 on normal and leukemic murine cells.

1 reference

12 December 2020

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction

1 reference

12 December 2020

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

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12 December 2020

Involvement of IL-6 signal transducer gp130 in IL-11-mediated signal transduction.

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12 December 2020

B-cell-stimulatory factor 2 (beta 2 interferon) functions as a second signal for interleukin 2 production by mature murine T cells

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12 December 2020

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor

1 reference

12 December 2020

Human interleukin 6 is a direct promoter of maturation of megakaryocytes in vitro

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12 December 2020

cDNA cloning of murine interleukin-HP1: homology with human interleukin 6.

1 reference

12 December 2020

Identification of a novel interleukin-6 response element containing an Ets-binding site and a CRE-like site in the junB promoter

1 reference

12 December 2020

Purification of adult rat sciatic nerve ciliary neuronotrophic factor.

1 reference

12 December 2020

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

1 reference

12 December 2020

Molecular cloning and expression of the murine interleukin-5 receptor.

1 reference

12 December 2020

Increased osteoclast development after estrogen loss: mediation by interleukin-6

1 reference

12 December 2020

Interleukin-6 (IL-6) functions as an in vitro autocrine growth factor in renal cell carcinomas

1 reference

12 December 2020

Interactions between oncostatin M and the IL-6 signal transducer, gp130.

1 reference

12 December 2020

A macrophage-derived factor required by plasmacytomas for survival and proliferation in vitro

1 reference

12 December 2020

Three-dimensional solution structure of human interleukin-4 by multidimensional heteronuclear magnetic resonance spectroscopy

1 reference

12 December 2020

Mutational analysis of the intracellular domain of the human growth hormone receptor

1 reference

12 December 2020

Hepatocyte-stimulating factor III shares structural and functional identity with leukemia-inhibitory factor

1 reference

12 December 2020

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain

1 reference

12 December 2020

Leukemia inhibitory factor and interleukin-6 trigger the same immediate early response, including tyrosine phosphorylation, upon induction of myeloid leukemia differentiation

1 reference

12 December 2020

Expression cloning of the murine and human interleukin 9 receptor cDNAs

1 reference

12 December 2020

Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts

1 reference

12 December 2020

LIF: lots of interesting functions

1 reference

12 December 2020

Hematopoietic growth factors activate the tyrosine phosphorylation of distinct sets of proteins in interleukin-3-dependent murine cell lines

1 reference

12 December 2020

Functional domains of the granulocyte colony-stimulating factor receptor

1 reference

12 December 2020

The cholinergic neuronal differentiation factor from heart cells is identical to leukemia inhibitory factor

1 reference

12 December 2020

Purification, cloning, and expression of ciliary neurotrophic factor (CNTF).

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF00202068

1 reference

27 September 2017

1 reference

PubMed ID

8834766