(Q411994)

English

secreted phosphoprotein 1

mammalian protein found in Homo sapiens

osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein
secreted phosphoprotein 1 variant 6
early T-lymphocyte activation 1
uropontin
urinary stone protein
SPP1
SPP-1
secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
osteopontin
Bone sialoprotein 1
nephropontin
SPP1/CALPHA1 fusion
Secreted phosphoprotein 1 (Osteopontin, bone sialoprotein I, early T-lymphocyte activation 1), isoform CRA_b
SPP1 protein, human

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

2 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10451

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/A0A024RDE2

Osteopontin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

2 references

13 November 2019

UniProt protein ID

UniProt protein ID

17 September 2016

2 references

13 November 2019

UniProt protein ID

UniProt protein ID

20 March 2016

language of work or name

molecular function

cytokine activity

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

protein binding

determination method

8 references

1 January 2018

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

1 January 2018

Osteopontin expression is an independent adverse prognostic factor in resectable gastrointestinal stromal tumor and its interaction with CD44 promotes tumor proliferation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

1 January 2018

A Single Kinase Generates the Majority of the Secreted Phosphoproteome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

1 January 2018

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

1 January 2018

Clinical implication and mitotic effect of CD44 cleavage in relation to osteopontin/CD44 interaction and dysregulated cell cycle protein in gastrointestinal stromal tumor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

1 January 2018

Secreted kinase phosphorylates extracellular proteins that regulate biomineralization

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

1 January 2018

Towards a proteome-scale map of the human protein–protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

1 January 2018

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

extracellular matrix binding

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

extracellular region

determination method

2 references

extracellular exosome

determination method

extracellular space

determination method

4 references

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10451&geneProductId=UniProtKB:P10451

determination method

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10451&geneProductId=UniProtKB:P10451

determination method

17 October 2017

Human colostrum: identification of minor proteins in the aqueous phase by proteomics

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10451&geneProductId=UniProtKB:P10451

determination method

17 October 2017

Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10451&geneProductId=UniProtKB:P10451

determination method

endoplasmic reticulum lumen

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

extracellular space

determination method

5 references

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

1 January 2018

Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

1 January 2018

Human colostrum: identification of minor proteins in the aqueous phase by proteomics

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

extracellular exosome

determination method

1 reference

1 January 2018

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

extracellular space

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RDE2

determination method

biological process

response to vitamin D

determination method

1 reference

1 January 2018

Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

determination method

2 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RDE2

determination method

biomineral tissue development

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

extracellular matrix disassembly

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10451&geneProductId=UniProtKB:P10451

determination method

extracellular matrix organization

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

decidualization

determination method

1 reference

1 January 2018

Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

embryo implantation

determination method

1 reference

1 January 2018

Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

determination method

4 references

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

androgen catabolic process

determination method

1 reference

1 January 2018

Osteopontin promotes aromatase expression and estradiol production in human adipocytes

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

post-translational protein modification

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

1 January 2018

Osteopontin promotes aromatase expression and estradiol production in human adipocytes

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

cellular response to testosterone stimulus

determination method

1 reference

1 January 2018

Osteopontin promotes aromatase expression and estradiol production in human adipocytes

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

positive regulation of estradiol secretion

determination method

1 reference

1 January 2018

Osteopontin promotes aromatase expression and estradiol production in human adipocytes

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

regulation of signaling receptor activity

determination method

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10451

determination method

positive regulation of bone resorption

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RDE2

determination method

osteoblast differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RDE2

determination method

Gene Atlas image

PBB GE SPP1 209875 s at fs.png
732 × 530; 11 KB

0 references

http://purl.uniprot.org/uniprot/P10451

1 reference

Identifiers.org

Osteopontin, conserved site

2 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P10451

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/A0A024RDE2

Identifiers

CAS Registry Number

1 reference

https://chem.nlm.nih.gov/chemidplus/rn/106441-73-0

MeSH descriptor ID

subject named as

SPP1 protein, human

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

UniProt protein ID

20 March 2016

language of work or name

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

UniProt protein ID

20 March 2016

language of work or name

0 references

Ensembl protein ID

ENSP00000378517

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378517

ENSP00000237623

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000237623

ENSP00000354042

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000354042

ENSP00000477824

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000477824

ENSP00000422973

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000422973

1 reference

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

0 references

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(14 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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