(Q41200948)

English

Frequency of Spontaneous Resistance to Peptide Deformylase Inhibitor GSK1322322 in Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae

scientific article published on 26 May 2015

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

Frequency of Spontaneous Resistance to Peptide Deformylase Inhibitor GSK1322322 in Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae (English)

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

Streptococcus pneumoniae

1 reference

based on heuristic

inferred from title

Streptococcus pyogenes

object named as

Streptococcus pyogenes

1 reference

based on heuristic

inferred from title

Staphylococcus aureus

1 reference

based on heuristic

inferred from title

Haemophilus influenzae

object named as

Haemophilus influenzae

1 reference

based on heuristic

inferred from title

author name string

Sharon Min

1

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

Karen Ingraham

2

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

Jianzhong Huang

3

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

Lynn McCloskey

4

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

Sarah Rilling

5

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

Anne Windau

6

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

Jason Pizzollo

7

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

Deborah Butler

8

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

Kelly Aubart

9

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

Linda A Miller

10

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

Magdalena Zalacain

11

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

David J Holmes

12

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

Karen O'Dwyer

13

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

language of work or name

0 references

publication date

26 May 2015

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

Antimicrobial Agents and Chemotherapy

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

59

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

8

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

4644-4652

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

Safety, tolerability, and efficacy of GSK1322322 in the treatment of acute bacterial skin and skin structure infections

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

Safety, tolerability and pharmacokinetics of repeat dosing of the antibiotic GSK1322322, a peptide deformylase inhibitor: a randomized placebo-controlled study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

Comparative analysis of the antibacterial activity of a novel peptide deformylase inhibitor, GSK1322322.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

Single-dose safety, tolerability, and pharmacokinetics of the antibiotic GSK1322322, a novel peptide deformylase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

Understanding the origins of time-dependent inhibition by polypeptide deformylase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

Mutations in three distinct loci cause resistance to peptide deformylase inhibitors in Bacillus subtilis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

Reduced susceptibility of Haemophilus influenzae to the peptide deformylase inhibitor LBM415 can result from target protein overexpression due to amplified chromosomal def gene copy number

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

Peptide deformylase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

Reducing the fitness cost of antibiotic resistance by amplification of initiator tRNA genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

Antimicrobial activity of a novel peptide deformylase inhibitor, LBM415, tested against respiratory tract and cutaneous infection pathogens: a global surveillance report (2003-2004).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

Comparative antimicrobial characterization of LBM415 (NVP PDF-713), a new peptide deformylase inhibitor of clinical importance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

Crystal structure of type II peptide deformylase from Staphylococcus aureus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

Resistance of Streptococcus pneumoniae to deformylase inhibitors is due to mutations in defB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

Peptide deformylase as an antibacterial drug target: target validation and resistance development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

Peptide deformylase as an antibacterial drug target: assays for detection of its inhibition in Escherichia coli cell homogenates and intact cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

Antibiotic Activity and Characterization of BB-3497, a Novel Peptide Deformylase Inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

Peptide deformylase in Staphylococcus aureus: resistance to inhibition is mediated by mutations in the formyltransferase gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

Crystal structure of the Escherichia coli peptide deformylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

Structure of crystalline Escherichia coli methionyl-tRNA(f)Met formyltransferase: comparison with glycinamide ribonucleotide formyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

On the release of the formyl group from nascent protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

Deformylation and protein biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

Disruption of the gene for Met-tRNA(fMet) formyltransferase severely impairs growth of Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

Staphylococcus aureus formyl-methionyl transferase mutants demonstrate reduced virulence factor production and pathogenicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

28 September 2017

Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

14 June 2018

Structure-function relationships within the peptide deformylase family. Evidence for a conserved architecture of the active site involving three conserved motifs and a metal ion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

14 June 2018

Safety, tolerability, and pharmacokinetics of oral and intravenous administration of GSK1322322, a peptide deformylase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

19 August 2018

Role of the AcrAB-TolC efflux pump in determining susceptibility of Haemophilus influenzae to the novel peptide deformylase inhibitor LBM415.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

19 August 2018

Mechanism of time-dependent inhibition of polypeptide deformylase by actinonin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

19 August 2018

In vitro antibacterial activity of the peptide deformylase inhibitor BB-83698.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

19 August 2018

Formylation is not essential for initiation of protein synthesis in all eubacteria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

19 August 2018

Mapping of the active site zinc ligands of peptide deformylase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505285

19 August 2018

Cleavage of the N-terminal formymlethionine residue from a bacteriophage coat protein in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/26014938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.00484-15

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

release_mnxxudiynvehba6gskg74pghua

1 reference

https://api.fatcat.wiki/v0/release/mnxxudiynvehba6gskg74pghua

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

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