(Q41201521)

28 September 2017

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title

The use of therapeutic drug monitoring to optimise immunosuppressive therapy (English)

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28 September 2017

S M Tsunoda

1

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PubMed ID

8906895

28 September 2017

F T Aweeka

series ordinal

2

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28 September 2017

1 February 1996

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Clinical Pharmacokinetics

28 September 2017

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28 September 2017

30

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28 September 2017

2

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28 September 2017

107-140

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https://scigraph.springernature.com/pub.10.2165/00003088-199630020-00003

28 September 2017

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cites work

Specific and nonspecific monoclonal 125I-Incstar assays

1 reference

12 December 2020

Relationship between the dose and whole blood level of cyclosporine after liver and kidney transplantation

1 reference

12 December 2020

Infections with cytomegalovirus and other herpesviruses in 121 liver transplant recipients: transmission by donated organ and the effect of OKT3 antibodies

1 reference

12 December 2020

Minimal low dosage of cyclosporine therapy in renal transplantation by careful monitoring of high-performance liquid chromatography whole blood trough levels

1 reference

12 December 2020

Determination of a new immunosuppressant, mycophenolate mofetil, and its active metabolite, mycophenolic acid, in rat and human body fluids by high-performance liquid chromatography

1 reference

12 December 2020

A radioreceptor assay for the measurement of cyclosporine activity: a preliminary report

1 reference

12 December 2020

Radioreceptor assay for quantifying FK-506 immunosuppressant in whole blood

1 reference

12 December 2020

Correlation of rejection episodes with FK 506 dosage, FK 506 level, and steroids following primary orthotopic liver transplant

1 reference

12 December 2020

Metabolites of cyclosporine: blood and tissue levels. Biological activity?

1 reference

12 December 2020

Effectiveness of a second course of OKT3 monoclonal anti-T cell antibody for treatment of renal allograft rejection

1 reference

12 December 2020

Cyclosporine and metabolites in blood from renal allograft recipients with nephrotoxicity, rejection, or good renal function: comparative high-performance liquid chromatography and monoclonal radioimmunoassay studies

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12 December 2020

Chemiluminescence immunoassay of cyclosporine in whole blood

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12 December 2020

Correlation of cyclosporine and metabolite binding to cyclophilin and a 50 kDa binding protein with in vitro immunosuppression: a preliminary report

1 reference

12 December 2020

Optimization of sampling time for cyclosporine monitoring in transplant patients

1 reference

12 December 2020

Abbott TDx monoclonal antibody assay evaluated for measuring cyclosporine in whole blood

1 reference

12 December 2020

Tacrolimus. A review of its pharmacology, and therapeutic potential in hepatic and renal transplantation

1 reference

12 December 2020

The Neoral formulation: improved correlation between cyclosporine trough levels and exposure in stable renal transplant recipients

1 reference

12 December 2020

Human erythrocyte thiopurine methyltransferase: radiochemical microassay and biochemical properties

1 reference

12 December 2020

Consensus document: Hawk's Cay meeting on therapeutic drug monitoring of cyclosporine

1 reference

12 December 2020

Reduced inter- and intraindividual variability in cyclosporine pharmacokinetics from a microemulsion formulation

1 reference

12 December 2020

FK506 trough levels in whole blood and plasma in liver transplant recipients. Correlation with clinical events and side effects

1 reference

12 December 2020

The synergistic effects of cyclosporine, sirolimus, and brequinar on heart allograft survival in mice

1 reference

12 December 2020

Nonselective measurement of cyclosporine for therapeutic drug monitoring by fluorescence polarization immunoassay with a rabbit polyclonal antibody: I. Evaluation of the serum methodology and comparison with a sheep polyclonal antibody in an 3H-trac

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12 December 2020

The effects of menopause and hormone replacement therapies on prednisolone and erythromycin pharmacokinetics

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12 December 2020

The effect of graft function on FK506 plasma levels, dosages, and renal function, with particular reference to the liver

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12 December 2020

Therapeutic monitoring of cyclosporine, FK-506, and rapamycin

1 reference

12 December 2020

Influence of early cyclosporine dosage and plasma and whole blood levels on acute rejections in cadaveric renal allograft recipients

1 reference

12 December 2020

Monitoring FK 506 concentrations in plasma and whole blood

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12 December 2020

The Effects of Azathioprine and 6 mp on Immunity

1 reference

12 December 2020

The clinical pharmacology of 6-mercaptopurine

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12 December 2020

Cyclosporine plasma levels six hours after oral administration. A useful tool for monitoring therapy

1 reference

12 December 2020

Comparative analyses of cyclosporine in whole blood and plasma by radioimmunoassay, fluorescence polarization immunoassay, and high-performance liquid chromatography

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12 December 2020

Comparison of cyclosporine blood concentrations measured by radioimmunoassay and two nonisotopic immunoassays using monoclonal antibodies

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12 December 2020

Michaelis-Menten kinetics determine cyclosporine steady-state concentrations: a population analysis in kidney transplant patients.

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12 December 2020

In vivo use of OKT3: main issues for the monitoring of treated patients

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12 December 2020

Cyclosporin A tissue levels in a cadaveric renal allograft recipient

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12 December 2020

Failure of 125I-tracer selective monoclonal antibody levels on a whole blood matrix to predict rejection or nephrotoxic episodes in renal transplant patients under anti-lymphocyte globulin and prednisone therapy

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12 December 2020

Influence of a fat-rich meal on the pharmacokinetics of a new oral formulation of cyclosporine in a crossover comparison with the market formulation.

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12 December 2020

Inhibition of anti-OKT3 antibody generation by cyclosporine--results of a prospective randomized trial

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12 December 2020

Cyclosporine analysis by high-performance liquid chromatography: precision, accuracy, and minimum detectable quantity

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12 December 2020

Cyclosporine monitoring in renal transplantation: area under the curve monitoring is superior to trough-level monitoring

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12 December 2020

Liver transplantation in Birmingham--use of cyclosporine--clinical correlations with drug measurements

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12 December 2020

The value of serial serum trough cyclosporine levels in human renal transplantation

1 reference

12 December 2020

Mycophenolic acid binding to human serum albumin: characterization and relation to pharmacodynamics

1 reference

12 December 2020

Cyclosporine plasma levels in renal transplant patients. Association with renal toxicity and allograft rejection

1 reference

12 December 2020

Blood cyclosporin concentrations and the short-term risk of lung rejection following heart-lung transplantation

1 reference

12 December 2020

Human liver thiopurine methyltransferase pharmacogenetics: biochemical properties, liver-erythrocyte correlation and presence of isozymes

1 reference

12 December 2020

Rapamycin inhibits p34cdc2 expression and arrests T lymphocyte proliferation at the G1/S transition.

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12 December 2020

Antimurine antibody to OKT3 in cardiac transplantation: implications for prophylaxis and retreatment of rejection

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12 December 2020

Cyclosporine monitoring in autoimmune and other diseases

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12 December 2020

Current results and expectations of renal transplantation

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12 December 2020

6-Thioguanine-induced DNA damage as a determinant of cytotoxicity in cultured Chinese hamster ovary cells

1 reference

12 December 2020

Cyclosporine blood concentrations in the management of renal transplant recipients

1 reference

12 December 2020

In vitro assessment of FK 506 immunosuppressive activity in transplant patients

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12 December 2020

A preliminary study to evaluate an in vitro assay for determining patient whole blood immunosuppressive cyclosporine A and metabolite activity: comparison with cytosolic binding assays using cyclophilin or a 50-kilodalton binding protein, and the Ab

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12 December 2020

Comparison of cyclosporin A measurement in whole blood by six different methods.

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12 December 2020

Cyclosporine monitoring with polyclonal and specific monoclonal antibodies during episodes of renal allograft dysfunction

1 reference

12 December 2020

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity

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12 December 2020

Rejection and infection after pediatric cardiac transplantation

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12 December 2020

Cyclosporine A monitoring in patients with renal, cardiac, and liver transplants: a comparison between fluorescence polarization immunoassay and two different RIA methods.

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12 December 2020

Relationship of OKT3 sensitization and vascular rejection in cardiac transplant patients receiving OKT3 rejection prophylaxis

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12 December 2020

Restriction of the human in vivo immune response against the mouse monoclonal antibody OKT3

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12 December 2020

Pharmacokinetic study of orthoclone OKT3 serum levels during treatment of acute renal allograft rejection

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12 December 2020

Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection. European Mycophenolate Mofetil Cooperative Study Group

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12 December 2020

Comparison of Different Assays for the Quantitation of FK 506 Levels in Blood or Plasma

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12 December 2020

A whole blood FK 506 assay for the IMx analyzer

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12 December 2020

Therapeutic cyclosporine monitoring: comparison of radioimmunoassay and high-performance liquid chromatography methods in organ transplant recipients

1 reference

12 December 2020

The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients

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12 December 2020

French multicentre study: comparison of two specific and four nonspecific methods for Sandimmune (cyclosporine) blood and plasma (separated at 37 degrees C or at 22 degrees C) monitoring

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12 December 2020

Production of synergistic but nonidentical mechanisms of immunosuppression by rapamycin and cyclosporine

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12 December 2020

Cyclosporine in whole blood: drug monitoring difficulties and presentation of a reliable normal-phase liquid chromatographic assay

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12 December 2020

Comparison of plasma vs whole blood as matrix for FK 506 drug level monitoring

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12 December 2020

Cyclophilin: a specific cytosolic binding protein for cyclosporin A

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12 December 2020

Pharmacokinetics and tolerability of a microemulsion formulation of cyclosporine in renal allograft recipients--a concentration-controlled comparison with the commercial formulation

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12 December 2020

Bioassay of plasma specimens from liver transplant patients on FK 506 immunosuppression

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12 December 2020

Drug-binding proteins in liver transplant patients

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12 December 2020

The clinical significance of cyclosporine metabolites

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12 December 2020

Specific enzyme-multiplied immunoassay and fluorescence polarization immunoassay for cyclosporin compared with Cyclotrac [125I]radioimmunoassay

1 reference

12 December 2020

Isolation, identification, and biological activities of oxidative metabolites of FK506, a potent immunosuppressive macrolide lactone

1 reference

12 December 2020

FK 506: a novel immunosuppressant for treatment of autoimmune disease. Rationale and preliminary clinical experience at the University of Pittsburgh

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12 December 2020

FK 506: monitoring in plasma or in whole blood?

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12 December 2020

Comparison of the utility of 3H-based specific monoclonal antibody assay on whole blood samples with the fluorescence polarization nonspecific immunoassay on serum samples for diagnosis of adverse events in renal transplant patients

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12 December 2020

Improvement and assessment of enzyme-linked immunosorbent assay to detect low FK506 concentrations in plasma or whole blood within 6 hours

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12 December 2020

Early cellular rejection after orthotopic liver transplantation correlates with low concentrations of FK506 in hepatic tissue

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12 December 2020

Complications and monitoring of OKT3 therapy

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12 December 2020

Quality assessment of cyclosporine measurements: comparison of current methods

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12 December 2020

A prospective study of cyclosporine concentration in relation to its therapeutic effect and toxicity after renal transplantation

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12 December 2020

Analysis of pharmacokinetic profiles in 232 renal and 87 cardiac allograft recipients treated with cyclosporine

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12 December 2020

Pilot study of mycophenolate mofetil (RS-61443) in the prevention of acute rejection following renal transplantation in Japanese patients. RS-61443 Investigation Committee--Japan.

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12 December 2020

Reexposure to OKT3 in renal allograft recipients

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12 December 2020

Immunologic monitoring during and after OKT3 therapy

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12 December 2020

Utility of pretransplantation cyclosporine pharmacokinetic studies

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12 December 2020

Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism

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12 December 2020

Derivatives of cyclosporin compatible with antibody-based assays: I. The generation of [125I]-labeled cyclosporin

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12 December 2020

Induction of Interleukin 2 Messenger RNA Inhibited by Cyclosporin A

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12 December 2020

Soluble interleukin-2 receptor monitoring during bacterial and viral infections in liver transplant recipients: a comparative evaluation

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12 December 2020

Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA.

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12 December 2020

Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders

1 reference

12 December 2020

Monitoring of blood levels of cyclosporine in renal and cardiac transplant recipients--comparison of HPLC to Incstar CYCLO-Trac SP RIA.

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12 December 2020

Failure of whole blood cyclosporine levels to provide a reliable measure of immunosuppression in clinical heart and heart/lung transplantation

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12 December 2020

A highly sensitive method to assay FK-506 levels in plasma

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12 December 2020

Cyclosporine monitoring in liver allograft recipients: two distinct patterns of blood level derangement associated with nephrotoxicity

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12 December 2020

P450 3A activity and cyclosporine dosing in kidney and heart transplant recipients

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12 December 2020

Association of elevated FK 506 plasma levels with nephrotoxicity in liver-grafted patients

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12 December 2020

Monitoring of cyclosporine by serial posttransplant pharmacokinetic studies in renal transplant patients

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12 December 2020

A review of assay methods for cyclosporin. Clinical implications

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12 December 2020

Randomized prospective trial of OKT3 for early prophylaxis of rejection after liver transplantation

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12 December 2020

Cyclosporin A rapidly inhibits mediator release from human basophils presumably by interacting with cyclophilin

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12 December 2020

Immunologic monitoring in OKT3-treated kidney graft recipients

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12 December 2020

Randomised trial comparing tacrolimus (FK506) and cyclosporin in prevention of liver allograft rejection. European FK506 Multicentre Liver Study Group

1 reference

12 December 2020

Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat

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12 December 2020

Studies of cyclosporine blood levels: analysis, clinical utility, pharmacokinetics, metabolites, and chronopharmacology

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12 December 2020

Computer-guided concentration-controlled trials in autoimmune disorders

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12 December 2020

Measurement of cyclosporine in plasma of cardiac allograft recipients by fluorescence polarization immunoassay

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12 December 2020

Plasma FK506 levels in patients with histopathologically documented renal allograft rejection

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12 December 2020

Comparison of the pharmacokinetics of cyclosporine Sandimmune with Sandimmune Neoral in stable renal transplant patients

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12 December 2020

Monitoring of cyclosporine blood levels with polyclonal and monoclonal assays during episodes of renal graft dysfunction

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12 December 2020

Tacrolimus: a potential new treatment for autoimmune chronic active hepatitis: results of an open-label preliminary trial

1 reference

12 December 2020

Cyclosporin A monitoring in Australia: consensus recommendations

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12 December 2020

Biological effects of cyclosporin A: A new antilymphocytic agent

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12 December 2020

The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine

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12 December 2020

A reversed phase high performance liquid chromatography approach in determining total red blood cell concentrations of 6-thioguanine, 6-mercaptopurine, methylthioguanine, and methylmercaptopurine in a patient receiving thiopurine therapy

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12 December 2020

Pharmacodynamic assays of the immunosuppressive action of cyclosporine therapy in transplant recipients

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12 December 2020

Azathioprine myelotoxicity related to elevated 6-thioguanine nucleotides in heart transplantation

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12 December 2020

Quantitation of plasma azathioprine and 6-mercaptopurine levels in renal transplant patients

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12 December 2020

Cyclosporin A pharmacokinetics in liver transplant recipients in relation to biliary T-tube clamping and liver dysfunction

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12 December 2020

Pharmacodynamic monitoring of cyclosporin

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12 December 2020

Therapeutic drug monitoring of cyclosporin. Practical applications and limitations

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12 December 2020

Cyclosporin A mediated immunosuppression in vitro: effect on high affinity interleukin-2 receptor expression and -turnover

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12 December 2020

Area under the curve monitoring of cyclosporine therapy: the early posttransplant period.

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12 December 2020

Sensitivity of CYCLO-Trac-SP (specific monoclonal immunoassay for cyclosporin A)

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12 December 2020

Cyclosporine nephrotoxicity is minimized by adjusting dosage on the basis of drug concentration in blood

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12 December 2020

Concentrations of cyclosporin A and its metabolites in human tissues postmortem.

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12 December 2020

Cyclosporin blood levels do correlate with clinical complications

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12 December 2020

Abbott TDx "selective" assay overestimates cyclosporine in whole blood.

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12 December 2020

THE REVERSAL OF REJECTION IN HUMAN RENAL HOMOGRAFTS WITH SUBSEQUENT DEVELOPMENT OF HOMOGRAFT TOLERANCE

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12 December 2020

Blood cyclosporin A and metabolite kinetic profiles after administration of Sandimmune soft gelatine capsules and Neoral in transplant recipients

1 reference

12 December 2020

Oral 6-mercaptopurine in childhood leukemia: parent drug pharmacokinetics and active metabolite concentrations

1 reference

12 December 2020

Sandimmun neoral, a new oral formulation of cyclosporin A with improved pharmacokinetic characteristics: safety and tolerability in renal transplant patients

1 reference

12 December 2020

Monitoring cyclosporin A (ciclosporin, INN) concentrations in whole blood: evaluation of the EMIT assay in comparison with HPLC and RIA.

1 reference

12 December 2020

Cyclosporine monitoring in kidney and liver transplant patients: comparison between radioimmunoassay (37 degrees C plasma) and high-performance liquid chromatography (whole blood) measurements

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12 December 2020

Monoclonal fluorescence polarization immunoassay evaluated for monitoring cyclosporine in whole blood after kidney, heart, and liver transplantation

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12 December 2020

Measurement of cyclosporine by liquid chromatography and three immunoassays in blood from liver, cardiac, and renal transplant recipients

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12 December 2020

Variations in serum OKT3 concentration based upon age, sex, transplanted organ, treatment regimen, and anti-OKT3 antibody status

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12 December 2020

Analytical performance of EMIT cyclosporine assay evaluated

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12 December 2020

Lake Louise Consensus Conference on cyclosporin monitoring in organ transplantation: report of the consensus panel.

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12 December 2020

Monitoring of azathioprine treatment by determination of 6-thioguanine nucleotide concentrations in erythrocytes

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12 December 2020

Immunological monitoring in cyclosporine-treated patients

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12 December 2020

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization

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12 December 2020

Blood cyclosporin concentrations and renal allograft dysfunction

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12 December 2020

Cyclosporine, FK506, and rapamycin. Some effects on early activation events in serum-free, mitogen-stimulated mouse spleen cells

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12 December 2020

Effect of cyclosporin A and dexamethasone on interleukin 2 receptor gene expression

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12 December 2020

Evaluation of Abbott TDx monoclonal assay of cyclosporine in whole blood

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12 December 2020

Japanese study of FK 506 on kidney transplantation: the benefit of monitoring the whole blood FK 506 concentration. Japanese FK 506 Study Group

1 reference

12 December 2020

Comparison of cyclosporine measurement in whole blood by high-performance liquid chromatography, monoclonal fluorescence polarization immunoassay, and monoclonal enzyme-multiplied immunoassay

1 reference

12 December 2020

Long-term cyclosporine pharmacokinetic changes in renal transplant recipients: effects of binding and metabolism

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12 December 2020

Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin

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12 December 2020

Randomized double-blind study of standard versus low-dose OKT3 induction therapy in renal allograft recipients

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12 December 2020

Determination of cyclosporine concentrations with monoclonal antibodies

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12 December 2020

Performance of the Sandoz radioimmunoassays for cyclosporine

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12 December 2020

Cyclosporine pharmacokinetics and variability from a microemulsion formulation--a multicenter investigation in kidney transplant patients

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12 December 2020

Prognostic significance of T cell associated surface antigen density changes during OKT3 therapy of renal allograft rejection.

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12 December 2020

Evaluation of instrumental, nonisotopic immunoassays (fluorescence polarization immunoassay and enzyme-multiplied immunoassay technique) for cyclosporine monitoring in whole blood after kidney and liver transplantation

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12 December 2020

Efficacy of low-dose OKT3 as cytolytic induction therapy in heart transplantation

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12 December 2020

Maintenance immunosuppression with prednisone and RS-61443 alone following liver transplantation.

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12 December 2020

The UNOS Scientific Renal Transplant Registry

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12 December 2020

Comparison of antimouse and antihorse antibody production during the treatment of allograft rejection with OKT3 or antithymocyte globulin

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12 December 2020

Adjustment of cyclosporine dosage in renal transplant patients based on concentration measured specifically in whole blood: clinical outcome results and diagnostic utility

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12 December 2020

Involvement of cyclosporine metabolites in therapeutic monitoring and immunosuppression

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12 December 2020

Therapeutic drug monitoring (immunosuppressive drugs).

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12 December 2020

Monitoring OKT3 treatment: pharmacodynamic and pharmacokinetic measures

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12 December 2020

A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine

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12 December 2020

Evaluation of EMIT Cyclosporine Assay for use with whole blood

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12 December 2020

Japanese study of FK 506 on kidney transplantation: results of late phase II study

1 reference

12 December 2020

Mycophenolate mofetil for the prevention of acute rejection in primary cadaveric renal allograft recipients. U.S. Renal Transplant Mycophenolate Mofetil Study Group

1 reference

12 December 2020

FK 506 renal toxicity and lack of detectable cytochrome P-450 3A in the liver graft of a patient undergoing liver transplantation

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12 December 2020

Laboratory monitoring of therapy with OKT3 and other murine monoclonal antibodies

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12 December 2020

Effect of temperature and hematocrit on plasma concentration of FK 506

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12 December 2020

Effect of hepatic dysfunction and T tube clamping on FK 506 pharmacokinetics and trough concentrations

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12 December 2020

Immunosuppressive therapy. The relation between clinical response and immunologic competence

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12 December 2020

Comparison of Abbott TDx fluorescence polarization immunoassay, Sandoz radioimmunoassay, and high-performance liquid chromatography methods for the assay of serum cyclosporine.

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12 December 2020

Cyclosporine levels are not helpful

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12 December 2020

Assay of FK 506 in plasma.

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12 December 2020

Effect of food on the pharmacokinetics of cyclosporine in healthy subjects following oral and intravenous administration

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12 December 2020

The role of genetic variation in thiopurine methyltransferase activity and the efficacy and/or side effects of azathioprine therapy in dermatologic patients

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12 December 2020

Specific 3H radioimmunoassay with a monoclonal antibody for monitoring cyclosporine in blood.

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12 December 2020

Comment on cyclosporine assay techniques: an attempt for recommendations

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12 December 2020

Factors Influencing the Pharmacokinetics of Cyclosporine in Man

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12 December 2020

The pharmacokinetic profile of standard and low-dose OKT3 induction immunosuppression in renal transplant recipients

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12 December 2020

Cyclosporine monitoring improves graft-versus-host disease prophylaxis after bone marrow transplantation

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12 December 2020

A reliable high-performance liquid chromatography assay for high-throughput routine cyclosporin A monitoring in whole blood

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12 December 2020

OKT3 monoclonal antibody plasma levels during therapy and the subsequent development of host antibodies to OKT3

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12 December 2020

Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia

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12 December 2020

A randomized clinical trial of OKT3 monoclonal antibody for acute rejection of cadaveric renal transplants

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12 December 2020

RS-61443--a phase I clinical trial and pilot rescue study

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12 December 2020

Low serum OKT3 levels correlate with failure to prevent rejection in orthotopic liver transplant patients.

1 reference

12 December 2020

Treatment of recurrent heart rejection with mycophenolate mofetil (RS-61443): initial clinical experience

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12 December 2020

Successful retreatment of allograft rejection with OKT3

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12 December 2020

A limited sampling strategy for the measurement of cyclosporine AUC

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12 December 2020

Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate mofetil

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12 December 2020

Specific monoclonal radioimmunoassay and fluorescence polarization immunoassay for trough concentration and area-under-the-curve monitoring of cyclosporine in renal transplantation

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12 December 2020

Is the monoclonal fluorescence polarization immunoassay for cyclosporine specific? Comparison with specific radioimmunoassay

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12 December 2020

Cyclosporine monitoring by fluorescence polarization immunoassay

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12 December 2020

Abbreviated kinetic profiles in area-under-the-curve monitoring of cyclosporine therapy.

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12 December 2020

A Comparison of Tacrolimus (FK 506) and Cyclosporine for Immunosuppression in Liver Transplantation

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12 December 2020

Monitoring of FK 506 blood levels in kidney transplant recipients

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12 December 2020

Cyclosporin monitoring: its role in autoimmune indications

1 reference

12 December 2020

Clinical pharmacokinetics of cyclosporin

1 reference

12 December 2020

The erythromycin breath test selectively measures P450IIIA in patients with severe liver disease

1 reference

12 December 2020

Assay of 6-thioguanine nucleotide, a major metabolite of azathioprine, 6-mercaptopurine and 6-thioguanine, in human red blood cells

1 reference

12 December 2020

Treatment of acute renal allograft rejection with OKT3 monoclonal antibody

1 reference

12 December 2020

Cyclosporin clinical pharmacokinetics

1 reference

12 December 2020

Relationship of cyclosporine pharmacokinetic parameters to clinical events in human renal transplantation.

1 reference

12 December 2020

The quantitative flow cytometric plasma OKT3 assay. Its potential application in cardiac transplantation

1 reference

12 December 2020

Assay of 6-thioinosinic acid and 6-thioguanine nucleotides, active metabolites of 6-mercaptopurine, in human red blood cells

1 reference

12 December 2020

Immunologic monitoring during OKT3 therapy

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12 December 2020

Value of cyclosporine measurements in renal transplant recipients immunosuppressed with triple therapy.

1 reference

12 December 2020

Efficacy of OKT3 retreatment for refractory cardiac allograft rejection

1 reference

12 December 2020

Synergistic interactions of cyclosporine and rapamycin to inhibit immune performances of normal human peripheral blood lymphocytes in vitro

1 reference

12 December 2020

Measurement of FK 506 by HPLC and isolation and characterization of its metabolites

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12 December 2020

OKT3 for induction immunosuppression in renal transplantation: a comparative study of high versus low doses

1 reference

12 December 2020

Measurement of cyclosporin A in whole blood by RIA, EMIT and FPIA: a comparative study

1 reference

12 December 2020

Influence of cyclosporine pharmacokinetics, trough concentrations, and AUC monitoring on outcome after kidney transplantation.

1 reference

12 December 2020

Studies on the xanthine oxidase activity of mammalian cells.

1 reference

12 December 2020

Diagnostic utility of whole blood cyclosporine measurements in renal transplantation using triple therapy

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12 December 2020

Results of a prospective, randomized double-blind study comparing standard vs low-dose OKT3 induction therapy

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12 December 2020

The incidence of antibody formation to OKT3 consequent to its use in organ transplantation

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12 December 2020

FK 506 assay past and present--characteristics of FK 506 ELISA

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12 December 2020

Clinical development of Orthoclone OKT3.

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12 December 2020

Clinical evaluation and therapeutic range of cyclosporine A as monitored by FPIA in kidney transplantation

1 reference

12 December 2020

Serum azathioprine and 6-mercaptopurine levels and immunosuppressive activity after azathioprine in uremic patients

1 reference

12 December 2020

Distribution and concentration of cyclosporin in human blood

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12 December 2020

Prevention of adverse clinical outcome by monitoring of cardiac transplant patients for murine monoclonal CD3 antibody (OKT3) sensitization

1 reference

12 December 2020

Failure to predict cyclosporine area under the curve using a limited sampling strategy.

1 reference

12 December 2020

Gamma interferon synthesis by human thymocytes and T lymphocytes inhibited by cyclosporin A

1 reference

12 December 2020

Azathioprine metabolism in kidney transplant recipients

1 reference

12 December 2020

Clinical correlations of cyclosporine HPLC and FPIA levels in renal transplant recipients

1 reference

12 December 2020

Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction

1 reference

12 December 2020

Sequential interleukin 2 and interleukin 2 receptor levels distinguish rejection from cyclosporine toxicity in liver allograft recipients

1 reference

12 December 2020

Cyclosporine blood level monitoring by three specific methods; RIA H3, RIA I125, and fluorescence polarization: comparison of accuracy, cost, reproducibility and percent recovery

1 reference

12 December 2020

Noninvasive tests of CYP3A enzymes

1 reference

12 December 2020

Monitoring cyclosporin: is it still important?

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12 December 2020

Critical issues in cyclosporine monitoring: report of the Task Force on Cyclosporine Monitoring

1 reference

12 December 2020

Area-under-the-curve versus trough level monitoring of cyclosporine concentration: critical assessment of dosage adjustment practices and measurement of clinical outcome

1 reference

12 December 2020

Advances in cyclosporine pharmacology, measurement, and therapeutic monitoring

1 reference

12 December 2020

Pharmacokinetics of FK 506 in transplant patients

1 reference

12 December 2020

Monoclonal antibody technology for cyclosporine monitoring

1 reference

12 December 2020

Pharmacokinetic strategies for cyclosporin therapy in organ transplantation

1 reference

12 December 2020

Experiences with the enzyme-multiplied immunoassay cyclosporine specific assay in a therapeutic drug monitoring laboratory

1 reference

12 December 2020

OKT3 therapy for hepatic allograft rejection. Differential response in adults and children

1 reference

12 December 2020

Demographic factors affecting the pharmacokinetics of cyclosporine estimated by radioimmunoassay

1 reference

12 December 2020

Routine monitoring of cyclosporine in whole blood and in kidney tissue using high performance liquid chromatography

1 reference

12 December 2020

Prolonged and repeated courses of OKT3 after liver transplantation

1 reference

12 December 2020

The optimal use of cyclosporin A in autoimmune diseases

1 reference

12 December 2020

Immunologic monitoring with Orthoclone OKT3 therapy

1 reference

12 December 2020

Cyclosporin metabolism in transplant patients

1 reference

12 December 2020

Production of tumor necrosis factor/cachectin by human B cell lines and tonsillar B cells

1 reference

12 December 2020

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients

1 reference

12 December 2020

Mycophenolate mofetil: a report of the consensus panel.

1 reference

12 December 2020

One-month prophylactic use of OKT3 in cadaver kidney transplant recipients

1 reference

12 December 2020

Experience with cyclosporine and steroids in clinical renal transplantation

1 reference

12 December 2020

Cyclosporine: structure, pharmacokinetics, and therapeutic drug monitoring

1 reference

12 December 2020

The mechanism of action of cyclosporin A and FK506

1 reference

12 December 2020

The use of mycophenolate mofetil (RS-61443) in human heart transplant recipients

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Pharmacokinetics, dosing principles, and blood level monitoring of FK506.

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Measurement of cyclosporine A by a specific radioimmunoassay with a monoclonal antibody and 125I tracer

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Cyclosporine metabolism in human liver: identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs.

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12 December 2020

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High performance liquid chromatography/mass spectrometry of FK 506 and its metabolites in blood, bile, and urine of liver grafted patients

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12 December 2020

A comparison of cyclosporine assays using sequential samples from selected transplant patients

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12 December 2020

Rapid detection of anti-OKT3 antibodies with the Transtat assay

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12 December 2020

Therapeutic monitoring of cyclosporine.

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12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.28.727

Identifiers

DOI

10.2165/00003088-199630020-00003

1 reference

PubMed ID

8906895

Dimensions Publication ID

28 September 2017

0 references

1 reference

PubMed ID

8906895